公开(公告)号：US5100900A

公开(公告)日：1992-03-31

申请号：US677718

申请日：1991-03-29

Applicant: Jurgen Stoltefuss ,  Horst Boshagen ,  Siegfried Goldmann ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

Inventor： Jurgen Stoltefuss ,  Horst Boshagen ,  Siegfried Goldmann ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

IPC: A61K31/47 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90 ,  C07D215/12 ,  C07D215/14 ,  C07D217/04 ,  C07D401/04 ,  C07D401/14 ,  C07D409/04 ,  C07D409/14 ,  C07D491/04 ,  C07D491/048

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D215/14 ,  C07D217/04 ,  C07D409/04 ,  C07D409/14 ,  C07D491/04

Abstract: Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## in which R.sup.6 - denotes hydrogen, halogen or straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms,R.sup.7 denotes aryl, thienyl or pyridyl, andR.sup.4 represents hydrogen, or optionally substituted alkyl, alkenyl, alkadienyl or alkynyl,and their physiologically acceptable salts.

Abstract translation: 式（I）的正性正向活性4-喹啉基 - 二氢吡啶，其中R 1和R 5相同或不同并且表示具有至多8个碳原子的直链或支链烷基，R 2表示硝基或氰基，或R 1和 R2一起形成下式的内酯环：R 3表示下式的基团：其中R 6表示氢，卤素或直链或支链烷基或烷氧基，每种情况下具有 至8个碳原子，R7表示芳基，噻吩基或吡啶基，R4表示氢或任选取代的烷基，烯基，链二烯基或炔基，及其生理上可接受的盐。