公开(公告)号：US20230101326A1

公开(公告)日：2023-03-30

申请号：US17896938

申请日：2022-08-26

Applicant: Waters Technologies Corporation

Inventor： MingCheng Xu ,  Darryl W. Brousmiche ,  Daniel P. Walsh ,  Nicole L. Lawrence ,  Kevin D. Wyndham

IPC: B01J13/14 ,  C08L83/04 ,  C08L39/06

Abstract: In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such core-shell particles and (b) flowing a mobile phase through the column.

公开(公告)号：US11604174B2

公开(公告)日：2023-03-14

申请号：US16684930

申请日：2019-11-15

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Sebastien Besner ,  Mark Basile ,  Martin Gilar

IPC: G01N30/74 ,  G01N21/33 ,  G01N30/32 ,  G01N30/34

Abstract: Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector. A first and second fluid pump manager control the flow of a first and second fluid to one or more heating/cooling devices, and a mixer receives and mixes the first and second fluids. An optical detector flow cell receives the fluid mixture from the mixer, and a pressure regulator controls the pressure at the optical detector flow cell. Thus, the composition, temperature, and pressure of a fluid mixture entering an optical detector flow cell can be controlled in real time.

公开(公告)号：US20230028806A1

公开(公告)日：2023-01-26

申请号：US17865960

申请日：2022-07-15

Applicant: Waters Technologies Corporation

Inventor： Timothy M. Raymond ,  Sean Eric Anderson

IPC: F04B43/00 ,  F04B43/12 ,  F04B49/20 ,  F04B49/06

Abstract: Described is a method for regulating a volume of liquid delivered by a peristaltic pump and a peristaltic pump system that can be used to perform the method. The method includes sensing an ambient temperature of the peristaltic pump. The peristaltic pump includes a pump motor. At least one of a motor speed and a motor operation duration is determined from the sensed temperature, a selected volume of liquid to be delivered and a predetermined correspondence of the motor speed to ambient temperature. The pump motor is operated at the determined motor speed or for the determined motor operation duration to deliver the selected volume of liquid from the peristaltic pump.

公开(公告)号：US20230013977A1

公开(公告)日：2023-01-19

申请号：US17823360

申请日：2022-08-30

Applicant: Waters Technologies Corporation

Inventor： Giuseppe Astarita ,  Darryl W. Brousmiche

IPC: G01N27/623 ,  G01N27/447 ,  G01N30/06 ,  G01N30/72 ,  G01N33/58 ,  G01N33/68

Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.

公开(公告)号：US20220412963A1

公开(公告)日：2022-12-29

申请号：US17338022

申请日：2021-06-03

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Matthew A. Lauber

IPC: G01N33/533 ,  C07D215/48

Abstract: Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.

公开(公告)号：US11511213B2

公开(公告)日：2022-11-29

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S. P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  B01D53/02 ,  C12M1/40 ,  C12M1/00 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US20220373517A1

公开(公告)日：2022-11-24

申请号：US17739603

申请日：2022-05-09

Applicant: Waters Technologies Corporation

Inventor： Peter MacKinnon ,  Michael R. Jackson

IPC: G01N30/06 ,  G01N30/32 ,  G01N30/16

Abstract: Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path. The first path and the second path are offset by a first predetermined volume, the third path and the fourth path are offset by a second predetermined volume, and the fifth path and the sixth path are also offset by the second predetermined volume.

公开(公告)号：US20220362741A1

公开(公告)日：2022-11-17

申请号：US17731952

申请日：2022-04-28

Applicant: Waters Technologies Corporation

Inventor： Nicole L. Lawrence ,  Darryl W. Brousmiche ,  Jessica Field ,  Daniel P. Walsh

IPC: B01J20/26 ,  B01D15/36 ,  B01J20/28 ,  B01J43/00

Abstract: In some aspects, the present disclosure pertains to chromatographic materials that comprise (a) a bulk material and (b) a zwitterionic polymer covalently linked to a surface of the bulk material, in which the zwitterionic polymer comprises one or more monomer residues that comprise an amide or urea moiety, a positively charged moiety, and a negatively charged moiety. Other aspects of the present disclosure pertain to chromatographic separation devices that comprise such chromatographic materials, to chromatographic methods that employ such chromatographic separation devices, and to kits that contain (i) such chromatographic materials and (ii) one or more chromatographic devices for containing such materials.

公开(公告)号：US11439977B2

公开(公告)日：2022-09-13

申请号：US15451005

申请日：2017-03-06

Applicant: Waters Technologies Corporation

Inventor： Nicole L. Lawrence ,  Beatrice W. Muriithi ,  Kevin D Wyndham

IPC: B01J20/289 ,  B01J20/32 ,  B01D15/34 ,  B01D15/38 ,  B01D15/40 ,  B01D15/30 ,  B01D15/32

Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a superficially porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, chemical stability, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.

公开(公告)号：US20220252558A1

公开(公告)日：2022-08-11

申请号：US17731318

申请日：2022-04-28

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Theodore A. Dourdeville

IPC: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/60

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.