公开(公告)号：US20060111406A1

公开(公告)日：2006-05-25

申请号：US10517581

申请日：2003-06-11

Applicant: Rafael Ferritto Crespo ,  Jose Martin ,  Maria Martinortega Finger ,  Isabel Rojo Garcia ,  Quanrong Shen ,  Alan Warshawsky ,  Yanping Xu

Inventor： Rafael Ferritto Crespo ,  Jose Martin ,  Maria Martinortega Finger ,  Isabel Rojo Garcia ,  Quanrong Shen ,  Alan Warshawsky ,  Yanping Xu

IPC: A61K31/44 ,  A61K31/433 ,  A61K31/428 ,  A61K31/42 ,  A61K31/195 ,  A61K31/381

CPC classification number: C07C235/06 ,  C07C69/734 ,  C07C233/18 ,  C07C235/08 ,  C07C235/14 ,  C07C235/20 ,  C07C235/22 ,  C07C235/24 ,  C07C235/26 ,  C07C235/34 ,  C07C323/41 ,  C07C2601/04 ,  C07C2601/14 ,  C07D211/32 ,  C07D213/40 ,  C07D217/06 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  C07D295/18 ,  C07D295/185 ,  C07D317/58 ,  C07D317/60 ,  C07D333/20

Abstract: The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I).

Abstract translation: 本发明涉及结构式（I）的化合物，组合物和化合物的用途。

公开(公告)号：US06967201B1

公开(公告)日：2005-11-22

申请号：US10031312

申请日：2000-07-21

Applicant: Karin Briner ,  Joseph Paul Burkhart ,  Timothy Paul Burkholder ,  Brian Eugene Cunningham ,  Matthew Joseph Fisher ,  William Harlan Gritton ,  Shawn Christopher Miller ,  Jeffrey Thomas Mullaney ,  Matthew Robert Reinhard ,  Dennis Charles Thompson ,  Leonard Larry Winneroski ,  Yanping Xu

Inventor： Karin Briner ,  Joseph Paul Burkhart ,  Timothy Paul Burkholder ,  Brian Eugene Cunningham ,  Matthew Joseph Fisher ,  William Harlan Gritton ,  Shawn Christopher Miller ,  Jeffrey Thomas Mullaney ,  Matthew Robert Reinhard ,  Dennis Charles Thompson ,  Leonard Larry Winneroski ,  Yanping Xu

IPC: A61K31/496 ,  A61K31/551 ,  A61P3/04 ,  A61P25/24 ,  A61P43/00 ,  C07D307/79 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

CPC classification number: C07D307/79 ,  C07D405/04 ,  C07D405/12

Abstract: The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5′, R6, R6′, R7, R7′, R8, and R8′ are as described in the specification.

Abstract translation: 本发明提供式I的5-羟色胺苯并呋喃基哌嗪：其中：A是下式的哌嗪和R 1，R 1，R 2，R 3， R 4，R 5，R 5，R 6，R 6，R 6， R SUP，R 7，R 7，R 8和R 8'如上所述 规格。

公开(公告)号：US06930120B2

公开(公告)日：2005-08-16

申请号：US10343476

申请日：2001-08-23

Applicant: Dawn Alisa Brooks ,  Alexander Glenn Godfrey ,  Sarah Beth Jones ,  James Ray McCarthy ,  Christopher John Rito ,  Leonard Larry Winneroski ,  Yanping Xu

Inventor： Dawn Alisa Brooks ,  Alexander Glenn Godfrey ,  Sarah Beth Jones ,  James Ray McCarthy ,  Christopher John Rito ,  Leonard Larry Winneroski ,  Yanping Xu

IPC: A61K31/421 ,  A61K31/422 ,  A61K31/4709 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P7/04 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D263/32 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D413/04 ,  C07D263/32 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

Abstract: Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: n is 2, 3, or 4 and W is CH2, CH(OH), C(O) or O; R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl-alkyl, heteroaryl-alkyl, cycloalkyl-alkyl, or t-butyl; R2 is H, alkyl, haloalkyl or phenyl; Y is an unsubstituted or substituted thiophen-2,5-diyl or phenylene; R3 is alkyl or haloalkyl; R4 is a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, quinolyl, pyridyl or benzo[1,3]dioxol-5-yl group; and R5 is H, alkyl, or aminoalkyl; are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.

Abstract translation: 由以下结构式（I）表示的化合物及其药学上可接受的盐，溶剂合物和水合物，其中：n为2,3或4，W为CH 2，CH（OH），C （O）或O; R 1是未取代或取代的芳基，杂芳基，环烷基，杂环烷基，芳基 - 烷基，杂芳基 - 烷基，环烷基 - 烷基或叔丁基; R2是H，烷基，卤代烷基或苯基; Y是未取代或取代的噻吩-2,5-二基或亚苯基; R3是烷基或卤代烷基; R4是取代或未取代的苯基，萘基，1,2,3,4-四氢萘基，喹啉基，吡啶基或苯并[1,3]二氧杂环戊烯-5-基; 并且R 5是H，烷基或氨基烷基; 可用于调节过氧化物酶体增殖物激活受体，特别是用于治疗糖尿病。

公开(公告)号：US09097052B2

公开(公告)日：2015-08-04

申请号：US14363330

申请日：2011-12-06

Applicant: Hao Chen ,  Yanping Xu

Inventor： Hao Chen ,  Yanping Xu

IPC: A47B96/04 ,  E05F15/12 ,  F25D23/02 ,  E05F15/63

CPC classification number: E05F15/63 ,  E05Y2201/426 ,  E05Y2800/73 ,  E05Y2900/31 ,  F25D23/02 ,  F25D23/028 ,  F25D2323/021

Abstract: A refrigerator, includes a cabinet having a refrigerating compartment therein; a door pivotably coupled with the cabinet to open or close the refrigerating compartment; and an auxiliary door-opening device. The auxiliary door-opening device includes: a swing arm, a servo driver which is disposed on the cabinet, has an output shaft coupled with the swing arm, and is configured to drive the swing arm to swing between a first predetermined position in which the swing arm pushes the door to separate from the cabinet and a second predetermined position in which the door is closed onto the cabinet; and a controller configured to actuate the servo driver when receiving a door-opening instruction, so that the servo driver drives the swing arm to move to the first predetermined position and then to return to the second predetermined position.

Abstract translation: 一种冰箱，包括其内具有冷藏室的柜体; 与所述机壳可转动地联接以打开或关闭所述冷藏室的门; 和辅助开门装置。 辅助开门装置包括：摆臂，设置在机壳上的伺服驱动器，具有与摆臂联接的输出轴，并且构造成驱动摆臂在第一预定位置之间摆动，在第一预定位置， 摆臂推动门与机柜分离，第二预定位置将门关闭到机柜上; 以及控制器，其被配置为当接收到开门指令时致动所述伺服驱动器，使得所述伺服驱动器驱动所述摆臂移动到所述第一预定位置，然后返回到所述第二预定位置。

公开(公告)号：US20140319992A1

公开(公告)日：2014-10-30

申请号：US14363330

申请日：2011-12-06

Applicant: Hao Chen ,  Yanping Xu

Inventor： Hao Chen ,  Yanping Xu

IPC: E05F15/12 ,  E05F15/18 ,  F25D23/02

CPC classification number: E05F15/63 ,  E05Y2201/426 ,  E05Y2800/73 ,  E05Y2900/31 ,  F25D23/02 ,  F25D23/028 ,  F25D2323/021

Abstract: A refrigerator, includes a cabinet having a refrigerating compartment therein; a door pivotably coupled with the cabinet to open or close the refrigerating compartment; and an auxiliary door-opening device. The auxiliary door-opening device includes: a swing arm, a servo driver which is disposed on the cabinet, has an output shaft coupled with the swing arm, and is configured to drive the swing arm to swing between a first predetermined position in which the swing arm pushes the door to separate from the cabinet and a second predetermined position in which the door is closed onto the cabinet; and a controller configured to actuate the servo driver when receiving a door-opening instruction, so that the servo driver drives the swing arm to move to the first predetermined position and then to return to the second predetermined position.

Abstract translation: 一种冰箱，包括其内具有冷藏室的柜体; 与所述机壳可转动地联接以打开或关闭所述冷藏室的门; 和辅助开门装置。 辅助开门装置包括：摆臂，设置在机壳上的伺服驱动器，具有与摆臂联接的输出轴，并且构造成驱动摆臂在第一预定位置之间摆动，在第一预定位置， 摆臂推动门与机柜分离，第二预定位置将门关闭到机柜上; 以及控制器，其被配置为当接收到开门指令时致动所述伺服驱动器，使得所述伺服驱动器驱动所述摆臂移动到所述第一预定位置，然后返回到所述第二预定位置。

公开(公告)号：US08088776B2

公开(公告)日：2012-01-03

申请号：US12297349

申请日：2007-04-19

Applicant: Thomas Daniel Aicher ,  Zhaogen Chen ,  Ronald Jay Hinklin ,  Gary Alan Hite ,  Alexei Pavlovych Krasutsky ,  Renhua Li ,  Jefferson Ray McCowan ,  Ashraf Saeed ,  Nancy June Snyder ,  James Lee Toth ,  Owen Brendan Wallace ,  Leonard Larry Winneroski, Jr. ,  Yanping Xu ,  Jeremy Schulenburg York

Inventor： Thomas Daniel Aicher ,  Zhaogen Chen ,  Ronald Jay Hinklin ,  Gary Alan Hite ,  Alexei Pavlovych Krasutsky ,  Renhua Li ,  Jefferson Ray McCowan ,  Ashraf Saeed ,  Nancy June Snyder ,  James Lee Toth ,  Owen Brendan Wallace ,  Leonard Larry Winneroski, Jr. ,  Yanping Xu ,  Jeremy Schulenburg York

IPC: A61K31/496 ,  A61K31/453 ,  C07D403/02 ,  C07D405/14

CPC classification number: C07D207/12 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D405/14 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β-HSD type 1 activity.

Abstract translation: 本发明公开了具有11＆amp; b -HSD 1型拮抗剂活性的式I化合物，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物，以及使用化合物和组合物治疗糖尿病，高血糖症，肥胖症，高血压，高脂血症，代谢综合征，认知障碍以及与其相关的其它病症的方法 ; -HSD 1型活动。

公开(公告)号：US07968585B2

公开(公告)日：2011-06-28

申请号：US12297906

申请日：2007-04-25

Applicant: Thomas Edward Mabry ,  Owen Brendan Wallace ,  Yanping Xu ,  Nancy June Snyder ,  Leonard Larry Winneroski, Jr.

Inventor： Thomas Edward Mabry ,  Owen Brendan Wallace ,  Yanping Xu ,  Nancy June Snyder ,  Leonard Larry Winneroski, Jr.

IPC: A01N43/38 ,  A01N43/36 ,  A61K31/40 ,  C07D209/54 ,  C07D209/96 ,  C07D207/00

CPC classification number: C07D209/44 ,  C07D401/10 ,  C07D403/10 ,  C07D487/10

Abstract: The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.

Abstract translation: 本发明公开了具有11＆amp; b -HSD 1拮抗剂活性的式（I）的新化合物，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物，以及使用化合物和组合物治疗糖尿病，高血糖症，肥胖症，高血压，高脂血症，代谢综合征以及与其相关的其它病症的方法。 1活动。

公开(公告)号：US07816349B2

公开(公告)日：2010-10-19

申请号：US12297969

申请日：2007-04-23

Applicant: John Gordon Allen ,  Alexei Pavlovych Krasutsky ,  Owen Brendan Wallace ,  Yanping Xu ,  Jeremy Schulenburg York

Inventor： John Gordon Allen ,  Alexei Pavlovych Krasutsky ,  Owen Brendan Wallace ,  Yanping Xu ,  Jeremy Schulenburg York

IPC: A61K31/54 ,  A61K31/535 ,  A61K31/445 ,  A61K31/497 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10

CPC classification number: C07D207/26 ,  C07D401/10

Abstract: The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity.

Abstract translation: 本发明公开了新颖的式I化合物：（I）具有11＆amp; -HSD 1型拮抗剂活性，以及​​制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物，以及使用化合物和组合物治疗糖尿病，高血糖症，肥胖症，高血压，高脂血症，代谢综合征，认知障碍以及与其相关的其它病症的方法。 -HSD类型1活动。

公开(公告)号：US07608639B2

公开(公告)日：2009-10-27

申请号：US10571961

申请日：2004-10-08

Applicant: Leonard Larry Winneroski, Jr. ,  Yanping Xu ,  Jeremy Schulenburg York

Inventor： Leonard Larry Winneroski, Jr. ,  Yanping Xu ,  Jeremy Schulenburg York

IPC: A61K31/44 ,  C07D211/92

CPC classification number: C07D213/30 ,  C07C59/68 ,  C07C59/70 ,  C07C59/90 ,  C07C317/22 ,  C07C323/52 ,  C07D213/64 ,  C07D213/643 ,  C07D213/69 ,  C07D239/26

Abstract: The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR), such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，例如综合征X ，II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X综合症和心血管疾病相关的其它疾病。

公开(公告)号：US20090099182A1

公开(公告)日：2009-04-16

申请号：US12297964

申请日：2007-04-24

Applicant: Renhua Li ,  Thomas Edward Mabry ,  Owen Brendan Wallace ,  Leonard Larry Winneroski, JR. ,  Yanping Xu

Inventor： Renhua Li ,  Thomas Edward Mabry ,  Owen Brendan Wallace ,  Leonard Larry Winneroski, JR. ,  Yanping Xu

IPC: A61K31/4015 ,  C07D207/27 ,  C07D403/10 ,  C07D413/10 ,  C07D401/10 ,  C07D401/04 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D207/26 ,  C07D207/27 ,  C07D401/02 ,  C07D401/10 ,  C07D401/14

Abstract: The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.

Abstract translation: 本发明公开了具有11β-HSD 1型拮抗剂活性的式I化合物，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物，以及使用化合物和组合物治疗糖尿病，高血糖症，肥胖症，高血压，高脂血症，代谢综合征和与11beta-HSD 1型相关的其它病症的方法 活动。