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31.发明授权公开(公告)号：US10172663B2
公开(公告)日：2019-01-08
申请号：US14994681
申请日：2016-01-13
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.
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公开(公告)号：US20180193596A1
公开(公告)日：2018-07-12
申请号：US15917532
申请日：2018-03-09
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
CPC classification number: A61M25/0084 , A61B5/6848 , A61M25/0074 , A61M25/0097 , A61M25/0108 , A61M25/0662 , A61M2025/0039 , A61M2025/0086 , A61M2025/0087 , A61M2025/0681 , A61M2202/0468 , A61M2210/12
Abstract: A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery.
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公开(公告)号：US09554849B2
公开(公告)日：2017-01-31
申请号：US14712861
申请日：2015-05-14
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
CPC classification number: A61B18/1492 , A61B5/0071 , A61B18/00 , A61B2018/00166 , A61B2018/00279 , A61B2018/00285 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00982 , A61B2018/143 , A61B2018/1475 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/10 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel. A method of treating hypertension involves injecting an ablative fluid such as ethanol deep into zones in the wall of the renal artery such that the zones of fluid merge to form a circumferential ablation ring at a depth which ablates sympathetic nerves while minimizing injury to interior layers of the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉或其他人体容器的壁的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层。 一种治疗高血压的方法包括将消融液体如乙醇深入注射到肾动脉壁中的区域中，使得流体区域合并以在消融交感神经的深度处形成圆周消融环，同时最小化内部层的损伤 血管壁。
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公开(公告)号：US20160120587A1
公开(公告)日：2016-05-05
申请号：US14932128
申请日：2015-11-04
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
IPC: A61B18/04
CPC classification number: A61B18/04 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/37 , A61B90/39 , A61B2018/00166 , A61B2018/00285 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00547 , A61B2018/00577 , A61B2018/046 , A61B2090/3735 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , A61B2090/3782 , A61B2090/3966 , A61M25/0084 , A61M25/0108 , A61M25/1002 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
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35.发明申请PERI-VASCULAR TISSUE ABLATION CATHETER WITH DEFLECTION SURFACE SUPPORT STRUCTURES 有权具有偏转表面支持结构的PERI-血管组织消融导管公开(公告)号：US20150005719A1
公开(公告)日：2015-01-01
申请号：US14320085
申请日：2014-06-30
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
CPC classification number: A61M25/10 , A61B18/00 , A61B18/04 , A61B2018/00011 , A61B2018/00279 , A61B2018/00404 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/0662 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉壁或人体的其他血管的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层，或在前列腺组织中。 该系统还可以包括限制和/或调节烧蚀流体渗透到血管壁组织内和超出血管壁的组织的深度的手段。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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Patent Agency Ranking
36.发明申请PERI-VASCULAR TISSUE ABLATION CATHETER WITH MECHANICAL SUPPORT STRUCTURES 审中-公开具有机械支撑结构的PERI-VASCULAR TISSUE ABLATION CATHETER公开(公告)号：US20140378906A1
公开(公告)日：2014-12-25
申请号：US14320078
申请日：2014-06-30
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
IPC: A61B18/04
CPC classification number: A61M25/10 , A61B18/00 , A61B18/04 , A61B2018/00011 , A61B2018/00279 , A61B2018/00404 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/0662 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉或其他人体容器的壁的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层，或在前列腺组织中。 该系统还可以包括限制和/或调节烧蚀流体渗透到血管壁组织内和超出血管壁的组织的深度的手段。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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37.发明申请PERI-VASCULAR TISSUE ABLATION CATHETER WITH SUPPORT STRUCTURES 有权具有支持结构的PERI-VASCULAR TISSUE ABLATION CATHETER公开(公告)号：US20140236103A1
公开(公告)日：2014-08-21
申请号：US14266726
申请日：2014-04-30
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
IPC: A61M5/158
CPC classification number: A61M25/10 , A61B18/00 , A61B18/04 , A61B2018/00011 , A61B2018/00279 , A61B2018/00404 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/0662 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉或其他人体容器的壁的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层，或在前列腺组织中。 该系统还可以包括限制和/或调节烧蚀流体渗透到血管壁组织内和超出血管壁的组织的深度的手段。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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公开(公告)号：US20250032761A1
公开(公告)日：2025-01-30
申请号：US18824566
申请日：2024-09-04
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
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公开(公告)号：US20240415573A1
公开(公告)日：2024-12-19
申请号：US18762406
申请日：2024-07-02
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
IPC: A61B18/14 , A61B5/0205 , A61B5/24 , A61B5/388 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/04 , A61B90/00 , A61M5/158 , A61M25/00 , A61M25/01 , A61M25/06
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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公开(公告)号：US20240307112A1
公开(公告)日：2024-09-19
申请号：US18593029
申请日：2024-03-01
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
IPC: A61B18/14 , A61B5/0205 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/04 , A61B90/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M25/01 , A61M25/06
CPC classification number: A61B18/1492 , A61B17/3403 , A61B17/3478 , A61B18/04 , A61B18/1477 , A61B90/39 , A61M5/3286 , A61M25/0084 , A61B5/0205 , A61B2017/22071 , A61B2018/00166 , A61B2018/00267 , A61B2018/00285 , A61B2018/00351 , A61B2018/00434 , A61B2018/00505 , A61B2018/00547 , A61B2018/00577 , A61B2018/046 , A61B2018/048 , A61B2018/1425 , A61B2018/1475 , A61B2090/376 , A61B2090/3966 , A61M5/158 , A61M2025/0004 , A61M2025/0087 , A61M2025/0186 , A61M25/0662 , A61M2205/192 , A61M2205/195
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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