公开(公告)号：US11932838B2

公开(公告)日：2024-03-19

申请号：US17746473

申请日：2022-05-17

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner ,  Alexander Meyer Wilks

IPC: C12M1/24 ,  C12M1/00 ,  C12N5/071

CPC classification number: C12M23/08 ,  C12M23/20 ,  C12N5/0682

Abstract: This disclosure provides a cell culture media extending material capable of releasing nutrients into the cell culture environment slowly overtime. In embodiments, this material is a part of a cell culture vessel. In embodiments, the material is a coating or a film on a surface of a cell culture material. In additional embodiments, the material is a surface upon which cells are cultured, such as a cell culture vessel or a microcarrier.

公开(公告)号：US20230323265A1

公开(公告)日：2023-10-12

申请号：US18023227

申请日：2021-08-26

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M23/50 ,  C12M23/44 ,  C12M29/04 ,  C12M23/48 ,  C12M29/20 ,  C12M41/14

Abstract: A cell culture system is provided that includes at least one multi-layered vessel for culturing cells, and a cabinet comprising an interior cavity enclosed by one or more sidewalls. The cabinet being configured to house the multi-layered vessel within the interior cavity. The multi-layered vessel includes a cell culture space within the multi-layered vessel. The cabinet can change an orientation of the multi-layered vessel from an upright orientation to a tilted orientation.

公开(公告)号：US20230279323A1

公开(公告)日：2023-09-07

申请号：US18195166

申请日：2023-05-09

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/32 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12

CPC classification number: C12M23/12 ,  B01L3/50273 ,  C12M23/38 ,  C12M25/04 ,  B01L2200/027 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0475

Abstract: A fluidic device for culturing cells includes a microplate and plate lid. The microplate includes multiple wells and channels, the channels extending between the wells such that the channels interconnect the wells. The plate lid releasably engages the microplate to thereby enclose the wells and the channels. The wells include a culture surface such that a cell culture medium received therein is deposited over the culture surface. At least one channel that extends between adjacent ones of the wells is spaced from the culture surfaces of the adjacent wells defining a gap between the at least one channel and the culture surfaces of the adjacent wells for collection of the cell culture medium.

公开(公告)号：US11684064B2

公开(公告)日：2023-06-27

申请号：US15774883

申请日：2016-11-03

Applicant: Corning Incorporated

Inventor： William Joseph Lacey ,  Gregory Roger Martin ,  Allison Jean Tanner

IPC: B01L3/00 ,  A01N1/02 ,  C12M1/00

CPC classification number: A01N1/0268 ,  B01L3/5082 ,  B01L3/50825 ,  C12M45/22 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/123

Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.

公开(公告)号：US20220389367A1

公开(公告)日：2022-12-08

申请号：US17776044

申请日：2020-10-26

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Mark Christian Sanson ,  Nikhil Baburam Vasudeo ,  Joseph Christopher Wall

IPC: C12M1/34 ,  C12M1/12 ,  C12M1/24

Abstract: A cell culture vessel, cell culture monitoring system, and Raman spectroscopy system for non-invasive measuring of a cell culture are provided. The vessel includes a cell culture chamber that operates as a closed system, a wall defining a boundary of the cell culture chamber and separating the interior space of the cell culture chamber from an exterior of the cell culture chamber, and a window disposed in the wall and separating the interior space of the cell culture chamber from an exterior of the cell culture chamber. The cell culture chamber includes an interior space for housing at least one of the cell culture and a cell culture media. The window includes a polymer and allows monitoring of the cell culture via a monitoring module disposed on the exterior without the monitoring module coming into physical contact with the cell culture or the cell culture media.

公开(公告)号：US20220220434A1

公开(公告)日：2022-07-14

申请号：US17613994

申请日：2020-05-22

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Ana Maria del Pilar Pardo ,  Allison Jean Tanner

IPC: C12N5/00 ,  C12M1/32

Abstract: The present disclosure relates to agarose and methylcellulose storage and transport mediums, systems for cell storage and transport, and cell storage and transport methods. The instantly-disclosed agarose and methylcellulose storage and transport medium is ideally suited for 3D spheroid cell culture storage and transport. In particular aspects, the storage and transport mediums, systems, and methods are used in combination with or performed in labware that combine 3D spheroid culture with a gas permeable, micro-patterned design that allows for protection and prolonged maintenance of spheroid cell (e.g. hepatocytes) viability and functionality during storage and transport.

公开(公告)号：US20220062186A1

公开(公告)日：2022-03-03

申请号：US17501325

申请日：2021-10-14

Applicant: CORNING INCORPORATED

Inventor： Ronald Allen Faris ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Jin Liu ,  Gregory Roger Martin

IPC: A61K9/28

Abstract: An ex vivo cell culture sustained release composition, including: a mixture comprising: a sustenant; and a non-biodegradable binder; and a non-biodegradable and water insoluble encapsulant coat that encapsulates the mixture, as defined herein. Also disclosed is a method for sustainably providing a sustenant to a cell culture in aqueous media, including contacting a cell culture with the sustained release composition.

公开(公告)号：US20210292696A1

公开(公告)日：2021-09-23

申请号：US16332608

申请日：2017-09-21

Applicant: Corning Incorporated

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M1/24 ,  C12M1/32 ,  C12M3/00

Abstract: Multi-layer cell culture devices and systems for culturing suspension and adherent cells via continuous gravity flow of culture media without the use of motorized equipment minimize the risk of contamination of the cell culture. A multi-layer cell culture device includes at least first and second chambers configured to contain fluid and to be fluidly connected such that fluid in the first chamber unidirectionally and continuously flows by gravity flow from the first chamber and into the second chamber. A multi-layer cell culture device can further include a third chamber configured to contain fluid and positioned below the second chamber such that fluid in the second chamber unidirectionally and continuously flows by gravity flow from the second chamber and into the third chamber. Methods of culturing cells using these devices and systems are also described.

公开(公告)号：US20210222103A1

公开(公告)日：2021-07-22

申请号：US16095799

申请日：2017-05-11

Applicant: Corning Incorporated

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M1/06

Abstract: A structured bag for cell culture is provided herein. The structured bag includes a top portion, a bottom portion having a shape, and a sidewall extending between the top portion and the bottom portion and at least partially defining an interior compartment for receiving fluid. The bottom portion is configured to maintain the shape to support the structured bag such that the structured bag is free standing when placed on a surface.

公开(公告)号：US20210189314A1

公开(公告)日：2021-06-24

申请号：US16758066

申请日：2018-11-05

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.