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    SYSTEM AND METHOD OF MONITORING AUTOREGULATION
    33.
    发明申请
    SYSTEM AND METHOD OF MONITORING AUTOREGULATION 审中-公开
    监控自动化系统及方法

    公开(公告)号：US20170000395A1

    公开(公告)日：2017-01-05

    申请号：US15194098

    申请日：2016-06-27

    Applicant: COVIDIEN LP

    Inventor： Paul S. Addison ,  James N. Watson

    IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/021

    CPC classification number: A61B5/14553 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/7221 ,  G06F19/00 ,  G16H50/20 ,  G16H50/50

    Abstract: A method for monitoring autoregulation includes using a processor for receiving blood pressure data and oxygen saturation data from a patient, fitting a dynamic model to the blood pressure data and the oxygen saturation data to determine one or more parameters of the dynamic model indicative of autoregulation, and determining the patient's autoregulation status based on the one or more parameters.

    Abstract translation: 一种用于监测自动调节的方法包括使用处理器从患者接收血压数据和氧饱和度数据，将动态模型拟合到血压数据和氧饱和度数据，以确定指示自动调节的动态模型的一个或多个参数， 以及基于所述一个或多个参数确定所述患者的自动调节状态。

    METHODS AND SYSTEMS FOR DETERMINING FLUID ADMINISTRATION
    34.
    发明申请
    METHODS AND SYSTEMS FOR DETERMINING FLUID ADMINISTRATION 审中-公开
    用于确定流体管理的方法和系统

    公开(公告)号：US20160220756A1

    公开(公告)日：2016-08-04

    申请号：US15006018

    申请日：2016-01-25

    Applicant: Covidien LP

    Inventor： Peter Doyle ,  Paul S. Addison ,  James N. Watson

    IPC: A61M5/172 ,  A61B5/00 ,  A61B5/1455

    CPC classification number: A61M5/1723 ,  A61B5/02416 ,  A61B5/02438 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/4848 ,  A61B5/4875

    Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

    Abstract translation: 提供了用于确定流体给药的方法和系统。 该系统可以基于受试者的流体反应性和局部氧饱和度来确定流体给药。 系统可以从外部源接收流体响应性和区域氧饱和度，或者可以基于接收到的生理信号来确定一个或两个。 在一些实施例中，系统可以基于流体响应性和区域氧饱和度确定是否施用流体。 在一些实施例中，系统可以基于流体响应性和区域氧饱和度来确定要施用的流体的量。 在一些实施方案中，系统可以确定流体给药的有效性。 在一些实施例中，系统可以提供确定的流体施用的指示，使得护理者可以实施适当的流体施用。 在一些实施例中，系统可以基于其确定来控制流体施用。

    NON-STATIONARY FEATURE RELATIONSHIP PARAMETERS FOR AWARENESS MONITORING
    35.
    发明申请
    NON-STATIONARY FEATURE RELATIONSHIP PARAMETERS FOR AWARENESS MONITORING 有权
    非静态特征关联参数用于意识监测

    公开(公告)号：US20150208940A1

    公开(公告)日：2015-07-30

    申请号：US14606943

    申请日：2015-01-27

    Applicant: Covidien LP

    Inventor： Paul S. Addison ,  James N. Watson

    IPC: A61B5/04 ,  A61B5/16 ,  A61B5/0496 ,  A61B5/0476 ,  A61B5/0488

    CPC classification number: A61B5/0476 ,  A61B5/4821 ,  A61B5/726

    Abstract: Methods and systems are presented for determining physiological information in a physiological monitor. A physiological signal (e.g., an EEG signal) received from a subject is wavelet transformed and first and second related features that vary in scale over time are identified in the transformed signal. First and second coupled ridges of the respective first and second related features may also be identified in the transformed signal. A non-stationary relationship parameter is determined and is indicative of the relationship between the first and second features and/or between the first and second ridges. Physiological information, which may be indicative of a level of awareness of a subject, is determined based on the non-stationary relationship parameter. This physiological information may be used, for example, in an operating room to monitor/regulate the subject's anesthetic state while under general anesthesia or in an intensive care unit to monitor the subject's sedateness and administer medication accordingly.

    Abstract translation: 呈现用于确定生理监测器中生理信息的方法和系统。 从被摄体接收的生理信号（例如，EEG信号）被小波变换，并且在变换的信号中识别出随时间变化的第一和第二相关特征。 相应的第一和第二相关特征的第一和第二耦合脊也可以在变换的信号中被识别。 确定非平稳关系参数并且指示第一和第二特征之间和/或第一和第二脊之间的关系。 基于非平稳关系参数来确定可以指示受试者的意识水平的生理信息。 该生理信息例如可以在手术室中用于在全身麻醉期间或在重症监护室中监测/调节受试者的麻醉状态以监测受试者的镇静性并相应地施用药物。

    APNEA ANALYSIS SYSTEM AND METHOD
    36.
    发明申请
    APNEA ANALYSIS SYSTEM AND METHOD 有权
    APNEA分析系统与方法

    公开(公告)号：US20150190088A1

    公开(公告)日：2015-07-09

    申请号：US14590609

    申请日：2015-01-06

    Applicant: Covidien LP

    Inventor： Bo Chen ,  Michael L. Mestek ,  Ron J. Kadlec ,  Niranjan Maharajh ,  Mark E. Kolnsberg ,  Corinne H. Johnson ,  James P. Ochs ,  Paul Stanley Addison ,  James N. Watson

    IPC: A61B5/00 ,  A61B5/1455 ,  A61B7/00 ,  A61B5/0205

    CPC classification number: A61B5/4818 ,  A61B5/02055 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/0836 ,  A61B5/087 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7278 ,  A61B5/7282 ,  A61B7/003

    Abstract: An apnea analysis system may include a photoplethysmographic (PPG) sub-system, a breath detection sub-system, and an apnea analysis module. An apnea analysis system includes a photoplethysmographic (PPG) sub-system, a breath detection sub-system, and an apnea analysis module. The PPG sub-system is configured to be operatively connected to an individual and output a PPG signal from the individual. The breath detection sub-system is configured to be operatively connected to the individual and output a breath signal from the individual. The apnea analysis module is in communication with the PPG sub-system and the breath detection sub-system. The apnea analysis module analyzes the breath signal and a respiratory component of the PPG signal and, based on the analysis, identifies a presence of apnea, differentiates between obstructive apnea and central apnea, and provides an indication of the identified apnea.

    Abstract translation: 呼吸暂停分析系统可以包括光电体积描记术（PPG）子系统，呼吸检测子系统和呼吸暂停分析模块。 呼吸暂停分析系统包括光电体积描记术（PPG）子系统，呼吸检测子系统和呼吸暂停分析模块。 PPG子系统被配置为可操作地连接到个体并从个体输出PPG信号。 呼吸检测子系统被配置为可操作地连接到个体并从个体输出呼吸信号。 呼吸暂停分析模块与PPG子系统和呼吸检测子系统进行通信。 呼吸暂停分析模块分析呼吸信号和PPG信号的呼吸成分，并且基于分析，识别呼吸暂停的存在，区分阻塞性呼吸暂停和中枢性呼吸暂停，并且提供所识别的呼吸暂停的指示。

    SYSTEM AND METHOD FOR GENERATING AN ADJUSTED FLUID RESPONSIVENESS METRIC
    37.
    发明申请
    SYSTEM AND METHOD FOR GENERATING AN ADJUSTED FLUID RESPONSIVENESS METRIC 有权
    用于产生调节流体响应度的系统和方法

    公开(公告)号：US20140323822A1

    公开(公告)日：2014-10-30

    申请号：US14258141

    申请日：2014-04-22

    Applicant: COVIDIEN LP

    Inventor： Paul Stanley Addison ,  Rui Wang ,  Scott McGonigle ,  James N. Watson

    IPC: A61B5/00

    CPC classification number: A61B5/0295 ,  A61B5/022 ,  A61B5/0816 ,  A61B5/14551

    Abstract: The present invention relates to physiological signal processing, and in particular to methods and systems for processing physiological signals to predict a fluid responsiveness of a patient. A medical monitor for monitoring a patient includes an input receiving a photoplethysmograph (PPG) signal representing light absorption by a patient's tissue. The monitor also includes a perfusion status indicator indicating a perfusion status of the PPG signal, and a fluid responsiveness predictor (FRP) calculator programmed to calculate an FRP value based on a respiratory variation of the PPG signal. The FRP calculator applies a correction factor based on the perfusion status indicator.

    Abstract translation: 本发明涉及生理信号处理，特别涉及用于处理生理信号以预测患者的流体反应性的方法和系统。 用于监测患者的医疗监视器包括接收表示患者组织的光吸收的光谱体积描记图（PPG）信号的输入。 该监视器还包括指示PPG信号的灌注状态的灌注状态指示器和被编程为基于PPG信号的呼吸变化计算FRP值的流体响应性预测器（FRP）计算器。 FRP计算器根据灌注状态指示器应用校正因子。

    SYSTEMS AND METHODS FOR ENSEMBLE AVERAGING IN PULSE OXIMETRY
    38.
    发明申请
    SYSTEMS AND METHODS FOR ENSEMBLE AVERAGING IN PULSE OXIMETRY 审中-公开
    用于在脉冲OXIMETRY中进行平均化的系统和方法

    公开(公告)号：US20140187884A1

    公开(公告)日：2014-07-03

    申请号：US13730415

    申请日：2012-12-28

    Applicant: COVIDIEN LP

    Inventor： Paul S. Addison ,  James N. Watson

    IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/1495 ,  A61B5/1455

    CPC classification number: A61B5/14551 ,  A61B5/7203 ,  A61B5/7235

    Abstract: Various methods and systems for ensemble averaging signals in a pulse oximeter are provided. An ensemble averaging method includes receiving an ensemble average signal corresponding to an ensemble average of electromagnetic radiation signals detected from a blood perfused tissue of a patient and receiving a pulse signal corresponding to a pulse detected by the pulse oximeter. The method also includes scaling a width of the ensemble average signal, a width of the pulse signal, or both to produce a scaled ensemble average signal and a scaled pulse signal having a substantially uniform width. The method further includes ensemble averaging the scaled ensemble average signal and the scaled pulse signal to produce an updated ensemble average signal having the substantially uniform width.

    Abstract translation: 提供了用于在脉搏血氧计中进行整体平均信号的各种方法和系统。 整体平均方法包括接收对应于从患者的血液灌注组织检测到的电磁辐射信号的整体平均值并且接收与由脉搏血氧计检测到的脉冲相对应的脉冲信号的整体平均信号。 该方法还包括缩小整体平均信号的宽度，脉冲信号的宽度或两者以产生缩放的整体平均信号和具有基本均匀的宽度的缩放的脉冲信号。 该方法还包括对经缩放的整体平均信号和缩放的脉冲信号进行整体平均以产生具有基本均匀宽度的更新的整体平均信号。

    Methods and systems for determining fluid administration
    39.
    发明授权
    Methods and systems for determining fluid administration 有权

    公开(公告)号：US11975175B2

    公开(公告)日：2024-05-07

    申请号：US16417885

    申请日：2019-05-21

    Applicant: Covidien LP

    Inventor： Peter Doyle ,  Paul S. Addison ,  James N. Watson

    IPC: A61M5/172 ,  A61B5/00 ,  A61B5/024 ,  A61B5/08 ,  A61B5/1455

    CPC classification number: A61M5/1723 ,  A61B5/08 ,  A61B5/14551 ,  A61B5/4848 ,  A61B5/4875 ,  A61B5/02416 ,  A61B5/02438 ,  A61B5/0816

    Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

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