公开(公告)号：US07101838B2

公开(公告)日：2006-09-05

申请号：US08905709

申请日：1997-08-05

Applicant: David Stern ,  Ann Marie Schmidt

Inventor： David Stern ,  Ann Marie Schmidt

IPC: A61K38/17

CPC classification number: A61K38/1774 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

Abstract: The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent accelerated atherosclerosis in the subject. The present invention also provides for a method to prevent a macrovessel disease in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent macrovessel disease in the subject.

Abstract translation: 本发明提供了预防易感患者的加速动脉粥样硬化的方法，其包括以有效预防受试者加速的动脉粥样硬化的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。 本发明还提供一种预防患者易患有大血管疾病的方法，其包括以有效预防受试者的宏观血管疾病的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。

公开(公告)号：US20060111850A1

公开(公告)日：2006-05-25

申请号：US11320826

申请日：2005-12-30

Applicant: David Stern ,  Peter Fiekowsky

Inventor： David Stern ,  Peter Fiekowsky

IPC: G06F19/00

CPC classification number: G01N21/6458 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346

Abstract: Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from a light source 100 and detecting the photons from the light fluoresced therefrom, and repeating the steps of exposure and detection until the substrate 230 is completely examined. The resulting data can be used to determine binding affinity of the targets to specific polymer sequences.

公开(公告)号：US20060078562A1

公开(公告)日：2006-04-13

申请号：US11197644

申请日：2005-08-03

Applicant: Adnan Mjalli ,  David Stern ,  Ye Tian ,  Jeffrey Webster ,  Robert Rothlein

Inventor： Adnan Mjalli ,  David Stern ,  Ye Tian ,  Jeffrey Webster ,  Robert Rothlein

IPC: A61K39/00 ,  G01N33/53 ,  C07H21/04 ,  C12P21/04 ,  C07K14/705

CPC classification number: C07K16/2803 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/30 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/042

Abstract: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.

Abstract translation: 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白H 2结构域的域间连接。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。

公开(公告)号：US20060021912A1

公开(公告)日：2006-02-02

申请号：US10903152

申请日：2004-07-30

Applicant: Tan-Jen Chen ,  Paul Keusenkothen ,  J. Wu ,  John Buchanan ,  Guang Cao ,  Larry Laccino ,  David Stern ,  Matthew Vincent

Inventor： Tan-Jen Chen ,  Paul Keusenkothen ,  J. Wu ,  John Buchanan ,  Guang Cao ,  Larry Laccino ,  David Stern ,  Matthew Vincent

IPC: C10G11/05

CPC classification number: C10G11/05 ,  C10G2400/20

Abstract: There is provided a catalyst composition having improved hydrothermal stability for the catalytic cracking of a hydrocarbon feedstock to selectively produce propylene. The catalyst composition comprises a first crystalline molecular sieve selected from the group consisting of IM-5, MWW, ITH, FER, MFS, AEL, and AFO and an effective amount of a stabilization metal (copper, zirconium, or mixtures thereof) exchanged into the molecular sieve. The catalyst finds application in the cracking of naphtha and heavy hydrocarbon feedstocks. When used in the catalytic cracking of heavier hydrocarbon feedstocks, the catalyst composition preferably comprises a second molecular sieve having a pore size that is greater than the pore size of the first molecular sieve. The process is carried out by contacting a feedstock containing hydrocarbons having at least 4 carbon atoms is contacted, under catalytic cracking conditions, with the catalyst composition.

公开(公告)号：US20050088722A1

公开(公告)日：2005-04-28

申请号：US10626627

申请日：2003-07-25

Applicant: Calvin Quate ,  David Stern

Inventor： Calvin Quate ,  David Stern

IPC: B01J19/00 ,  C40B40/06 ,  C40B60/14 ,  G01N37/00 ,  G03F7/20 ,  H01L21/027 ,  G02F1/29 ,  G02B26/08

CPC classification number: G03F7/70291 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G03F7/70283 ,  G03F7/704

Abstract: An improved optical photolithography system and method provides predetermined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled means for dynamically generating the predetermined light pattern, e.g., a spatial light modulator. Image patterns are stored in a computer and through electronic control of the spatial light modulator directly illuminate the wafer to define a portion of the polymer array, rather than being defined by a pattern on a photomask. Thus, in the Direct Write System each pixel is illuminated with an optical beam of suitable intensity and the imaging (printing) of an individual feature is determined by computer control of the spatial light modulator at each photolithographic step without the use of a photomask. The Direct Write System including a spatial light modulator is particularly useful in the synthesis of DNA arrays and provides an efficient means for polymer array synthesis by using spatial light modulators to generate a predetermined light pattern that defines the image patterns of a polymer array to be deprotected.

Abstract translation: 改进的光学光刻系统和方法提供由直接写入系统产生的预定光图案，而不使用光掩模。 直接写入系统通过使用用于动态生成预定光图案的计算机控制装置（例如空间光调制器）来提供投影在基板（例如，晶片）的表面上的预定光图案。 图像图案存储在计算机中，并且通过空间光调制器的电子控制直接照亮晶片以限定聚合物阵列的一部分，而不是由光掩模上的图案限定。 因此，在直写系统中，每个像素用适当强度的光束照射，并且通过在每个光刻步骤的计算机控制空间光调制器而不使用光掩模来确定单个特征的成像（打印）。 包括空间光调制器在内的直接写入系统在DNA阵列的合成中特别有用，并且通过使用空间光调制器产生限定要去保护的聚合物阵列的图像图案的预定光图案来提供聚合物阵列合成的有效手段 。

公开(公告)号：US20050059847A1

公开(公告)日：2005-03-17

申请号：US10661985

申请日：2003-09-12

Applicant: David Stern

Inventor： David Stern

IPC: C07C5/27 ,  C07C2/64

CPC classification number: C07C5/2724 ,  C07C2523/36 ,  C07C2523/42 ,  C07C2529/40 ,  C07C15/08

Abstract: A process for the isomerization of xylenes and the conversion of ethylbenzene to benzene and ethane using a catalyst system comprising two catalysts. The first catalyst is unselectivated and comprises: (a) an intermediate pore size zeolite, e.g., ZSM-5; (b) at least one hydrogenation component to deethylate ethylbenzene, e.g. Group VIII and/or Group VIIIB metal; and (c) an amorphous binder, said first catalyst requiring at least 50 minutes to sorb 30% of the equilibrium capacity of ortho-xylene at 120° C. and at an ortho-xylene partial pressure of 4.5±0.8 mm of mercury. The second catalyst comprises an intermediate pore size zeolite, e.g., ZSM-5, and requires less than 50 minutes to sorb 30% of the equilibrium capacity of ortho-xylene at 120° C. and at an ortho-xylene partial pressure of 4.5±0.8 mm of mercury. The amount of first catalyst present in the catalyst system is a volume greater than 55 percent based on the sum of the volumes of the first catalyst and second catalyst.

Abstract translation: 使用包含两种催化剂的催化剂体系，二甲苯异构化和乙苯转化为苯和乙烷的方法。 第一催化剂未被选择，并包括：（a）中等孔径沸石，例如ZSM-5; （b）至少一种氢化组分使乙苯脱乙基化， VIII族和/或VIIIB族金属; 和（c）无定形粘合剂，所述第一催化剂需要至少50分钟以吸附邻二甲苯在120℃和邻近二甲苯分压为4.5±0.8mm汞柱的平衡容量的30％。 第二催化剂包括中等孔径的沸石，例如ZSM-5，并且需要少于50分钟以吸附邻二甲苯在120℃下的平均容量的30％，邻二甲苯分压为4.5± 0.8毫米汞柱 存在于催化剂体系中的第一催化剂的量是基于第一催化剂和第二催化剂的体积总和大于55％的体积。

公开(公告)号：US06555651B2

公开(公告)日：2003-04-29

申请号：US08948131

申请日：1997-10-09

Applicant: David Stern ,  Shi Du Yan ,  Ann Marie Schmidt ,  Ira Lamster

Inventor： David Stern ,  Shi Du Yan ,  Ann Marie Schmidt ,  Ira Lamster

IPC: A61K3800

CPC classification number: C07K14/70503 ,  A01K2217/075 ,  A61K38/00

Abstract: The present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation endproduct (RAGE). The present invention also provides for an isolated peptide having an amino acid sequence A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-K-P-P-Q-R-L-E-W-K (SEQ. ID No: 1). The present invention provides for a pharmaceutical composition comprising a therapeutically effect amount of an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of RAGE. The present invention also provides for a method for inhibiting interaction of an amyloid-&bgr; peptide with a receptor for advanced glycation end product which is on the surface of a cell, which comprises contacting the cell with the peptide or a functionally equivalent agent, wherein the peptide or agent is capable of inhibiting interaction of the amyloid-&bgr; peptide with the receptor for advanced glycation end product, and the peptide or agent is present in an amount effective to inhibit interaction of the amyloid-&bgr; peptide with the receptor for advanced glycation endproduct.

Abstract translation: 本方法提供了具有对应于晚期糖基化终产物（RAGE）受体的V-结构域的氨基酸序列的氨基酸序列的分离的肽。 本发明还提供具有氨基酸序列A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-P-P-Q-R-L-E-W-K（SEQ ID NO：1）的分离肽。 本发明提供了一种药物组合物，其包含治疗有效量的具有对应于RAGE的V-结构域的氨基酸序列的氨基酸序列的分离的肽。 本发明还提供了抑制淀粉样蛋白-β肽与细胞表面上的晚期糖基化终产物的受体的相互作用的方法，其包括使细胞与肽或功能等同试剂接触，其中 肽或试剂能够抑制淀粉样蛋白β肽与晚期糖基化终产物的受体的相互作用，并且肽或试剂以有效抑制淀粉样蛋白-β肽与晚期糖基化终产物受体相互作用的量存在 。

公开(公告)号：US06315995B1

公开(公告)日：2001-11-13

申请号：US09053871

申请日：1998-04-01

Applicant: David J. Pinsky ,  David Stern ,  Ann Marie Schmidt ,  Eric Rose ,  Robert A. Solomon

Inventor： David J. Pinsky ,  David Stern ,  Ann Marie Schmidt ,  Eric Rose ,  Robert A. Solomon

IPC: A61K3816

CPC classification number: C12N9/644 ,  A61K38/4846 ,  C07K14/70564 ,  C07K16/2854 ,  C12Y304/21022

Abstract: The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable Factor IXa compound in a sufficient amount over a sufficient time period so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IXa in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.

Abstract translation: 本发明提供一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的药学上可接受的因子IXa化合物，以治疗受试者的缺血性疾病。 本发明还提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IXa以抑制凝血，以便治疗缺血性疾病 学科。

公开(公告)号：USD341373S

公开(公告)日：1993-11-16

申请号：US850122

申请日：1992-03-12

Applicant: David Stern

Designer： David Stern

公开(公告)号：US09265428B2

公开(公告)日：2016-02-23

申请号：US12175803

申请日：2008-07-18

Applicant: David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

Inventor： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/07

CPC classification number: A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

Abstract: A wireless sensor for indicating a physical state within an environment includes a housing defining a hermetically sealed cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

Abstract translation: 用于指示环境中的物理状态的无线传感器包括限定密封空腔的壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。