公开(公告)号：US07811585B2

公开(公告)日：2010-10-12

申请号：US11775131

申请日：2007-07-09

Applicant: Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

Inventor： Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

IPC: A61K39/02

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The present invention relates to antigens, more particularly an antigen of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine component for therapy and/or prophylaxis.

Abstract translation: 本发明涉及用作治疗和/或预防的疫苗组分的抗原，更特别是化脓性链球菌（也称为A链球菌（GAS））细菌病原体的抗原。

公开(公告)号：US07749499B2

公开(公告)日：2010-07-06

申请号：US11929887

申请日：2007-10-30

Applicant: Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

Inventor： Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

IPC: A61K39/395 ,  A61K39/40 ,  C07K16/00 ,  C12P21/06 ,  G01N33/53

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/522 ,  C07K14/22

Abstract: The identification of a highly conserved, immunologically accessible antigen at the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from three Neisseria meningitidis strains and from one Neisseria gonorrhoeae strain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of the Neisseria surface protein, and antibodies that bind to this protein are also disclosed.

公开(公告)号：US20100119507A1

公开(公告)日：2010-05-13

申请号：US12568457

申请日：2009-09-28

Applicant: Denis Martin ,  Bernard Brodeur ,  Josee Hamel ,  Stephane Rioux ,  Patrick Rheault

Inventor： Denis Martin ,  Bernard Brodeur ,  Josee Hamel ,  Stephane Rioux ,  Patrick Rheault

IPC: A61K39/395 ,  A61K39/02 ,  G01N33/569 ,  C12P21/06 ,  A61K38/16 ,  C07K14/315 ,  C07K16/12 ,  C07H21/02 ,  C07H21/04

CPC classification number: C07K14/315 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0208 ,  A61K39/092 ,  A61K2039/575 ,  C07K2319/00 ,  G01N33/56944 ,  G01N2333/315 ,  G01N2469/20

Abstract: The present invention relates to antigens, more particularly antigenS of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine component for therapy and/or prophylaxis.

Abstract translation: 本发明涉及可用作治疗和/或预防的疫苗组分的抗原，更特别是化脓性链球菌（也称为A链球菌（GAS））细菌病原体的抗原。

公开(公告)号：US20100029912A1

公开(公告)日：2010-02-04

申请号：US12503468

申请日：2009-07-15

Applicant: Normand Blais ,  Martine Boyer ,  Vincent Brichard ,  Jamila Louahed ,  Denis Martin ,  Remi Palmantier ,  Clement Rioux

Inventor： Normand Blais ,  Martine Boyer ,  Vincent Brichard ,  Jamila Louahed ,  Denis Martin ,  Remi Palmantier ,  Clement Rioux

IPC: C07K14/00

CPC classification number: A61K39/0011 ,  C07K2319/00 ,  C07K2319/42

Abstract: Fusion proteins comprising an antigen derived from NY-ESO-1 linked to an antigen derived from LAGE-1, which may further comprise carriers, fusion partners, or the like, are provided. Methods for preparing, formulating, and using such fusion proteins are also provided. Such proteins are useful a vaccine components for inducing an immune response against a range of cancer-antigen-bearing cells.

Abstract translation: 提供了包含与源自LAGE-1的抗原连接的NY-ESO-1的抗原的融合蛋白，其可以进一步包含载体，融合伴侣等。 还提供了制备，配制和使用这种融合蛋白的方法。 这样的蛋白质可用于诱导针对一定范围的具有癌 - 抗原的细胞的免疫应答的疫苗组分。

公开(公告)号：US07635482B2

公开(公告)日：2009-12-22

申请号：US11513421

申请日：2006-08-29

Applicant: Josee Hamel ,  Bernard R. Brodeur ,  Isabelle Pineau ,  Denis Martin ,  Clement Rioux ,  Nathalie Charland

Inventor： Josee Hamel ,  Bernard R. Brodeur ,  Isabelle Pineau ,  Denis Martin ,  Clement Rioux ,  Nathalie Charland

IPC: A61K39/02 ,  C07H21/04

CPC classification number: C07K14/3156 ,  A61K39/00

Abstract: Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.

Abstract translation: 公开了链球菌蛋白质和编码它们的多核苷酸。 所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。 还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

公开(公告)号：US20080107675A1

公开(公告)日：2008-05-08

申请号：US11929893

申请日：2007-10-30

Applicant: Bernard Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

Inventor： Bernard Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

IPC: A61K39/00 ,  C12P21/04 ,  A61P43/00

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/522 ,  C07K14/22

Abstract: The identification of a highly conserved, immunologically accessible antigen at the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from three Neisseria meningitidis strains and from one Neisseria gonorrhoeae strain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of the Neisseria surface protein, and antibodies that bind to this protein are also disclosed.

公开(公告)号：US20080107674A1

公开(公告)日：2008-05-08

申请号：US11929890

申请日：2007-10-30

Applicant: Bernard Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

Inventor： Bernard Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

IPC: A61K39/00 ,  C12P21/04 ,  A61P43/00

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/522 ,  C07K14/22

Abstract: The identification of a highly conserved, immunologically accessible antigen at the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from three Neisseria meningitidis strains and from one Neisseria gonorrhoeae strain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of the Neisseria surface protein, and antibodies that bind to this protein are also disclosed.

公开(公告)号：US07329500B2

公开(公告)日：2008-02-12

申请号：US10487783

申请日：2002-08-27

Applicant: Denis Martin ,  Josée Hamel ,  Bernard R. Brodeur ,  Stéphane Rioux ,  Julie Couture

Inventor： Denis Martin ,  Josée Hamel ,  Bernard R. Brodeur ,  Stéphane Rioux ,  Julie Couture

IPC: G01N33/53

CPC classification number: C07K14/212 ,  A61K39/00 ,  Y10S435/975

Abstract: The present invention relates to polypeptides of Moraxella (Branhamela) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.

Abstract translation: 本发明涉及可用于放射性泻药，诊断和/或治疗目的的莫拉氏菌（Branhamela）卡他氏菌多肽。

公开(公告)号：US07247308B2

公开(公告)日：2007-07-24

申请号：US10332231

申请日：2001-07-06

Applicant: Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

Inventor： Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

IPC: A61K39/09

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The present invention relates to antigens, more particularly an antigen of Streptococcus pygenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine component for therapy and/or prophylaxis.

Abstract translation: 本发明涉及可用作治疗和/或预防的疫苗组分的抗原，更特别是链球菌脓性链球菌（也称为A链球菌（GAS））的细菌病原体的抗原。

公开(公告)号：US20070014841A1

公开(公告)日：2007-01-18

申请号：US11349553

申请日：2006-02-08

Applicant: Denis Martin ,  Stephane Rioux

Inventor： Denis Martin ,  Stephane Rioux

IPC: A61K39/09 ,  A61K9/127

CPC classification number: A61K9/127 ,  A61K38/164 ,  A61K39/092 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2300/00

Abstract: The present invention relates to polypeptides, epitopes and antibodies directed to these epitopes, more particularly to the Sip polypeptide of Group B Streptococcus (GBS), also called Streptococcus agalactiae which may be used to prevent, diagnose and/or treat streptococcal infection.

Abstract translation: 本发明涉及针对这些表位的多肽，表位和抗体，更具体地涉及可用于预防，诊断和/或治疗链球菌感染的B族链球菌（GBS）的Sip多肽，也称为无乳链球菌（Streptococcus agalactia）。