公开(公告)号：US11692916B2

公开(公告)日：2023-07-04

申请号：US15934117

申请日：2018-03-23

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse

IPC: G01N1/38 ,  B01F9/00 ,  B01F15/00 ,  B01F29/15 ,  B01F29/34 ,  B01F31/22 ,  B01F35/213 ,  B01F35/511 ,  B01F35/22 ,  B01F35/221 ,  B01F35/33 ,  B01F101/23

CPC classification number: G01N1/38 ,  B01F29/15 ,  B01F29/34 ,  B01F31/22 ,  B01F35/213 ,  B01F35/2202 ,  B01F35/2206 ,  B01F35/2209 ,  B01F35/22142 ,  B01F35/511 ,  B01F35/331 ,  B01F35/332 ,  B01F2101/23 ,  G01N2001/386

Abstract: A method for mixing fluids in containers may include performing a mixing procedure on a plurality of containers on a container support, at least a portion of the plurality of containers being differently sized. The mixing procedure may include a plurality of mixing phases, wherein in each mixing phase the container support may be subjected to a mixing motion at a single rate for a period of time of about 5 seconds or longer, and wherein the single rate for at least one mixing phase of the plurality of mixing phases may differ from the single rate for at least one other mixing phase of the plurality of mixing phases. The mixing procedure also may include at least one non-mixing phase, wherein the container support may not be subjected to the mixing motion.

公开(公告)号：US20220364155A1

公开(公告)日：2022-11-17

申请号：US17878580

申请日：2022-08-01

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  Norbert D. Hagen ,  David Opalsky

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A receptacle distribution system includes a rotary distributor and a receptacle handoff device. The rotary distributor includes a motorized turntable with an upright wall, a distributor head for holding a receptacle, a hook configured to engage a receptacle for moving the receptacle into or out of the distributor head, and an a system for powered elevation of the distributor head. The receptacle handoff device is configured to transfer a receptacle from a first receptacle distributor to the rotary distributor and includes a receptacle yoke configured to hold a receptacle placed in the receptacle yoke with the first receptacle distributor, the receptacle yoke being rotatable between a first position to receive the receptacle and a second position to present the receptacle to the rotary distributor to enable the hook of the rotary distributor to pull the receptacle from the receptacle yoke and into the distributor head.

公开(公告)号：US20220162677A1

公开(公告)日：2022-05-26

申请号：US17668775

申请日：2022-02-10

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US10975416B2

公开(公告)日：2021-04-13

申请号：US16016152

申请日：2018-06-22

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

Abstract: One or more temperature cycles are applied to the contents of a processing vial closed by an interlocked cap within a thermal cycler. The processing vial and the interlocked cap are transferred from the thermal cycler to a storage compartment within the instrument with a transfer mechanism with a probe engaged with the cap. In the storage compartment, the processing vial and interlocked cap are moved to an access opening in the instrument and are removed from the instrument through the access opening.

公开(公告)号：US20210017578A1

公开(公告)日：2021-01-21

申请号：US17036307

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： Byron J. Knight ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.

公开(公告)号：USD896367S1

公开(公告)日：2020-09-15

申请号：US29690019

申请日：2019-05-03

Applicant: Gen-Probe Incorporated

Designer： David H. Combs ,  Ayra Baker ,  David A. Buse

公开(公告)号：USD888279S1

公开(公告)日：2020-06-23

申请号：US29698619

申请日：2019-07-18

Applicant: GEN-PROBE INCORPORATED

Designer： David A. Buse

公开(公告)号：USD855826S1

公开(公告)日：2019-08-06

申请号：US29610161

申请日：2017-07-10

Applicant: GEN-PROBE INCORPORATED

Designer： David A. Buse