公开(公告)号：US20050059894A1

公开(公告)日：2005-03-17

申请号：US10663998

申请日：2003-09-16

Applicant: Haishan Zeng ,  Mirjan Petek ,  James Dao ,  Branko Palcic ,  Gary Ferguson

Inventor： Haishan Zeng ,  Mirjan Petek ,  James Dao ,  Branko Palcic ,  Gary Ferguson

IPC: A61B1/04 ,  A61B5/00 ,  A61B6/00

CPC classification number: A61B1/00055 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: The present invention is an automated endoscopic device and diagnostic method, which performs at least one other disease detection method simultaneously during a white light endoscopic procedure. In some embodiments fluorescence imaging or spectroscopy is performed during the white light examination. In other embodiments, multi-modal imaging and/or spectroscopy may be performed and combined in a variety of ways. Because diagnostic modes other than white light are performed transparently in the background, the procedure is not significantly more complex for the clinician than the familiar white light examination. In some embodiments the present invention automatically detects suspicious tissue and informs the clinician of its presence. In other embodiments the present invention helps determine if a biopsy is required, and may further assist the clinician, for example, by providing an outline or otherwise guide the clinician in identifying and/or taking a biopsy of a suspicious site. In yet other embodiments, the present invention includes refinements afforded by incorporating a priori information, for example, patient history, previous endoscopy data, the results of qualitative and/or quantitative sputum cytology etc.

Abstract translation: 本发明是一种自动内窥镜装置和诊断方法，其在白光内窥镜手术中同时执行至少一种其它疾病检测方法。 在一些实施例中，在白光检查期间进行荧光成像或光谱学。 在其他实施例中，多模式成像和/或光谱可以以多种方式进行和组合。 因为除了白光之外的诊断模式在背景中是透明的，所以对于临床医师来说，程序并不比熟悉的白光检查复杂得多。 在一些实施例中，本发明自动检测可疑组织并通知临床医生其存在。 在其他实施方案中，本发明有助于确定是否需要活组织检查，并且可以进一步辅助临床医生，例如通过提供临时医师来鉴定和/或进行可疑部位的活检。 在其他实施方案中，本发明包括通过结合先验信息（例如患者病史，先前的内窥镜检查数据，定性和/或定量痰细胞学检查的结果等）而提供的改进。

公开(公告)号：US6128525A

公开(公告)日：2000-10-03

申请号：US901999

申请日：1997-07-29

Applicant: Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

Inventor： Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

IPC: A61B18/20 ,  A61N5/06 ,  A61N5/067 ,  A61B6/00

CPC classification number: A61N5/062 ,  A61B1/043 ,  A61B18/20 ,  A61B2018/00904 ,  A61N2005/0644 ,  A61N2005/067

Abstract: A method and apparatus for controlling the dosimetry of a photodynamic therapy that involves exposing a site to be treated to treatment light in order to generate toxic products at the site and other photoproducts. Often a photosensitizer drug is administered to the patient prior to treatment or the therapy relies on the presence of endogenous photosensitizers. The method comprises the steps of selecting a photoproduct having an identifying characteristic, which can be a fluorescence peak, and monitoring the photoproduct using the identifying characteristic (e.g. fluorescence) to determine the level of the photoproduct being generated. The photodynamic therapy is then terminated when the photoproduct being monitored reaches a predetermined level. The method allows for safe treatment of a site using photodynamic therapy and ensures that overexposure to treatment light leading to damage of normal tissue or underexposure leading to ineffective treatment of the lesion does not occur. Apparatus for automatically carrying out the method is also provided.

Abstract translation: 一种用于控制光动力疗法的剂量测定的方法和装置，其涉及将待治疗的部位暴露于治疗光，以便在该部位产生有毒产物和其它光产物。 在治疗之前通常将光敏剂药物施用于患者，或者治疗依赖于内源性光敏剂的存在。 该方法包括以下步骤：选择具有识别特征的光产物，其可以是荧光峰，并使用识别特征（例如荧光）监测光产物，以确定所产生的光产物的水平。 当被监测的光产物达到预定水平时，光动力疗法终止。 该方法允许使用光动力疗法安全治疗部位，并且确保不会发生过度暴露于治疗光，导致正常组织损伤或曝光不足导致病变无效治疗。 还提供了用于自动执行该方法的装置。

公开(公告)号：US6008889A

公开(公告)日：1999-12-28

申请号：US843605

申请日：1997-04-16

Applicant: Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

Inventor： Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

IPC: A61B5/00 ,  A61B5/103 ,  G01N21/64 ,  G01N21/65 ,  G01B9/02 ,  G01N11/00

CPC classification number: G01N21/474 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/444 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/475 ,  G01N2021/6417 ,  G01N2021/656 ,  G01N2201/0627

Abstract: Apparatus for diagnosis of a skin disease site using spectral analysis includes a light source for generating light to illuminate the disease site and a probe unit optically connected to the light source for exposing the disease site to light to generate fluorescence and reflectance light. The probe unit also collects the generated fluorescence and reflectance light and transmits this light to a spectrometer to be analysed. The spectrometer generates and displays spectral measurements of the fluorescence light and the reflectance light which in together assist the user in diagnosing the disease site. The apparatus makes use of a conventional personal computer using a plug-in spectrometer card to provide a compact and low cost system. The system performs combined fluorescence and reflectance spectral analysis in a quick and efficient manner to provide a powerful tool for dermatologic diagnosis.

Abstract translation: 用于使用光谱分析诊断皮肤疾病部位的装置包括用于产生照亮疾病部位的光的光源和与光源光学连接的探针单元，用于将疾病部位暴露于光以产生荧光和反射光。 探针单元还收集产生的荧光和反射光，并将该光传输到要分析的光谱仪。 光谱仪产生和显示荧光和反射光的光谱测量，这些在一起协助用户诊断疾病部位。 该装置利用使用插入式光谱仪卡的常规个人计算机来提供紧凑且低成本的系统。 该系统以快速有效的方式进行组合荧光和反射光谱分析，为皮肤病诊断提供强大的工具。