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公开(公告)号：US07081256B2
公开(公告)日：2006-07-25
申请号：US10171982
申请日：2002-06-17
Applicant: Ryuji Kubota , Hiroshi Araya , Kouki Obata , Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki
Inventor： Ryuji Kubota , Hiroshi Araya , Kouki Obata , Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki
CPC classification number: A61K31/4704 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054
Abstract: A quinolinone derivative pharmaceutical composition comprising a quinolinone derivative represented by the structural formula (I): wherein the quinolinone derivative is in the form of particles, which have an average particle diameter of 0.5 to 10 μm and such a particle size distribution that particles having a particle diameter of 15 μm or less account for 90% or more of the totality of the particles, and also have a fusion enthalpy of 30 J/g or more, and the surface of the particles are coated with a water-soluble composition containing a water-soluble polymer, can quickly dissolve an active ingredient in the digestive tract and is also superior in long-term storage stability.
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公开(公告)号：US06706733B2
公开(公告)日：2004-03-16
申请号：US10177137
申请日：2002-06-24
Applicant: Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki , Nahoko Muratake
Inventor： Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki , Nahoko Muratake
IPC: A61K3147
CPC classification number: C07D215/227
Abstract: The problem to be solved by the present invention is to provide a quinolinone derivative formulation, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I), which is useful as a pharmaceutical, and particularly as an antiallergic, which has superior bioabsorption and stability. The present invention provides a quinolinone derivative, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I):
Abstract translation: 本发明要解决的问题是提供一种喹啉酮衍生物制剂及其制备方法，其具有由化学式（I）表示的喹啉酮衍生物的β晶型和/或γ晶形式的活性成分，其中 可用作药物，特别是作为抗过敏药物，其具有优异的生物吸收和稳定性。 本发明提供了一种喹啉酮衍生物及其制备方法，其具有化学式（I）表示的喹啉酮衍生物的β晶型和/或γ晶形式的活性成分：
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公开(公告)号：US06627642B1
公开(公告)日：2003-09-30
申请号：US09830584
申请日：2001-05-08
Applicant: Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki , Nahoko Muratake
Inventor： Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki , Nahoko Muratake
IPC: A61K3147
CPC classification number: A61K31/4704 , C07D215/38
Abstract: The problem to be solved by the present invention is to provide a quinolinone derivative formulation, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I), which is useful as a pharmaceutical, and particularly as an antiallergic, which has superior bioabsorption and stability. The present invention provides a quinolinone derivative, and its production method, having for its active ingredient the &bgr; crystal form and/or &ggr; crystal form of the quinolinone derivative represented with chemical formula (I):
Abstract translation: 本发明要解决的问题是提供一种喹啉酮衍生物制剂及其制备方法，其具有由化学式（I）表示的喹啉酮衍生物的β晶型和/或γ晶形式的活性成分，其中 可用作药物，特别是作为抗过敏药物，其具有优异的生物吸收和稳定性。 本发明提供了一种喹啉酮衍生物及其制备方法，其具有化学式（I）表示的喹啉酮衍生物的β晶型和/或γ晶形式的活性成分：
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