公开(公告)号：US07313428B2

公开(公告)日：2007-12-25

申请号：US11003101

申请日：2004-12-03

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US06754521B2

公开(公告)日：2004-06-22

申请号：US10375825

申请日：2003-02-27

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Abstract translation: 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。 本发明包括用于监测和检测造影剂到动脉和感兴趣组织的检测系统。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06311085B1

公开(公告)日：2001-10-30

申请号：US09309311

申请日：1999-05-11

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US5590654A

公开(公告)日：1997-01-07

申请号：US580195

申请日：1995-12-28

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61K49/18 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/5635 ,  A61B5/201 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for monitoring and detecting the arrival of a contrast agent in a region of interest (e.g., an artery or tissues of interest). In one embodiment, upon detecting a maximum, substantially elevated or elevated concentration of contrast agent in the region of interest, a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention may be employed to facilitate synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement.

Abstract translation: 本发明是用于监测和检测造影剂到感兴趣区域（例如感兴趣的动脉或组织）的技术和装置。 在一个实施方案中，当检测到感兴趣区域中造影剂的最大，基本上升高或升高的浓度时，可以获得磁共振图像数据的预定部分（例如，代表k空间中心的数据） 。 因此，本发明可以用于促进将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。

公开(公告)号：US5579767A

公开(公告)日：1996-12-03

申请号：US420815

申请日：1995-04-12

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  G01R33/563 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Abstract translation: 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US5553619A

公开(公告)日：1996-09-10

申请号：US378384

申请日：1995-01-25

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

公开(公告)号：US5417213A

公开(公告)日：1995-05-23

申请号：US71970

申请日：1993-06-07

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of an magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate.

Abstract translation: 本发明是使用核磁共振成像与静脉内施用磁共振造影剂组合地静脉成像动脉的方法。 静脉注射造影剂，使得动脉对比浓度在足够长的时间段内基本上高于静脉和背景组织浓度以获得磁共振图像。 选择造影剂的注射部位，使得其处于远离感兴趣动脉的静脉中。 磁共振造影剂可以以可变的输注速率静脉内输注。

公开(公告)号：US20240390012A1

公开(公告)日：2024-11-28

申请号：US18394625

申请日：2023-12-22

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B17/135 ,  A61B5/00 ,  A61B5/055 ,  A61B17/132 ,  A61B90/00

Abstract: There are many inventions described herein as well as many aspects and embodiments of those inventions. A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical or conal-like shape of the thigh of a subject (for example, a human), the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. Notably, a snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid (for example, air) which is faster and less cumbersome for the operator.

公开(公告)号：US08200311B2

公开(公告)日：2012-06-12

申请号：US11737812

申请日：2007-04-20

Applicant: Pascal Spincemaille ,  Yi Wang ,  Martin R. Prince

Inventor： Pascal Spincemaille ,  Yi Wang ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/0263 ,  A61B5/0402 ,  A61B5/7285 ,  G01R33/4818 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56509 ,  G01R33/5673

Abstract: Described is a robust electrocardiogram (ECG) ordering technique of k-space for breath hold contrast enhanced magnetic resonance angiography (CE-MRA) that acquires the central part of k-space in a motion-free portion of diastole and fills in from the periphery of k-space at all other times. To make maximal use of the contrast enhancement, data is acquired continuously even when the ECG signal is lost. The ECG signal is monitored in real time. The ECG ordering technique allows a flexible acquisition matrix and is robust against ECG signal imperfections. The ECG ordering technique allows thoracic and pulmonary magnetic resonance angiography with a higher resolution when compared to the conventional gated sequence.

Abstract translation: 描述了一种用于持续对比增强磁共振血管造影（CE-MRA）的k空间的鲁棒心电图（ECG）排序技术，其获得舒张期的无运动部分中的k空间的中心部分并从周边填充 的k空间在其他时间。 为了最大限度地利用对比度增强，即使当ECG信号丢失时也可以连续获取数据。 ECG信号被实时监控。 ECG排序技术允许灵活的采集矩阵，并且针对ECG信号缺陷是鲁棒的。 与常规门控序列相比，ECG排序技术允许具有更高分辨率的胸廓和肺部磁共振血管造影。

公开(公告)号：US20120035435A1

公开(公告)日：2012-02-09

申请号：US13147072

申请日：2010-01-28

Applicant: Minkyung Grace Choi ,  Martin R. Prince

Inventor： Minkyung Grace Choi ,  Martin R. Prince

IPC: A61B5/0408 ,  A61B5/08

CPC classification number: A61B5/1135 ,  A61B5/04085 ,  A61B5/6831 ,  A61B5/7285 ,  A61B2562/164

Abstract: A device is provided for sensing an electrocardiogram signal of a patient. The device includes a substrate and a plurality of electrodes mounted to the substrate. The plurality of electrodes are configured to sense an electrocardiogram signal of a patient when the plurality of electrodes are placed in contact with the patient. The device may include a strap configured to wrap around a portion of the patient wherein the substrate mounts to the strap. The device further may include a respiration sensor mounted to the strap.

Abstract translation: 提供了用于感测患者的心电图信号的装置。 该器件包括衬底和安装到衬底的多个电极。 多个电极被配置为当多个电极与患者接触时感测患者的心电图信号。 该装置可以包括被配置成包裹患者的一部分的带，其中衬底安装到带上。 该装置还可以包括安装到带子上的呼吸传感器。