公开(公告)号：US09678007B2

公开(公告)日：2017-06-13

申请号：US13651196

申请日：2012-10-12

Applicant: Northwestern University

Inventor： Vadim Backman ,  Ji Yi

IPC: G06K9/00 ,  G01N21/47 ,  A61B5/00

CPC classification number: G01N21/4795 ,  A61B5/0066

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the backscattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

公开(公告)号：US20160331357A1

公开(公告)日：2016-11-17

申请号：US15156056

申请日：2016-05-16

Applicant: Nanocytomics, LLC ,  Northwestern University

Inventor： Jarema S. Czarnecki ,  Hariharan Subramanian ,  Yangrong (Elaine) Zhang ,  Vadim Backman ,  Hemant Roy

IPC: A61B10/02 ,  A61B10/04 ,  A61B42/10

CPC classification number: A61B10/02 ,  A61B10/0291 ,  A61B10/04 ,  A61B42/10 ,  A61B42/20 ,  A61B90/37 ,  A61B2010/0216 ,  A61B2017/00438 ,  A61B2017/320004 ,  A61B2017/320012 ,  A61B2217/007

Abstract: A sample collection apparatus or device, various abrasive devices or components, and methods for their use, are provided for collecting samples from within a mammalian body. Tissue collection and sample preparation is the gold standard in cytology. Many cell scrapers and abrasives and their respective methods of collection destroy cellular tissue, decreasing the quality of the sample. Devices for obtaining cell and tissue samples, can comprise a collection device which is inserted into a cavity, a finger worn collection device, a glove based collection device and respective abrasive instruments or components.

Abstract translation: 用于从哺乳动物体内收集样品的样品收集装置或装置，各种研磨装置或部件及其使用方法。 组织采集和样品制备是细胞学的黄金标准。 许多细胞刮刀和磨料及其收集的方法破坏细胞组织，降低了样品的质量。 用于获得细胞和组织样本的装置可以包括插入空腔中的收集装置，手指磨损收集装置，基于手套的收集装置和相应的研磨器具或部件。

公开(公告)号：US20130095519A1

公开(公告)日：2013-04-18

申请号：US13651196

申请日：2012-10-12

Applicant: Northwestern University

Inventor： Vadim Backman ,  Ji Yi

IPC: G01N21/45 ,  A61B6/00 ,  G06K9/36

CPC classification number: G01N21/4795 ,  A61B5/0066

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

Abstract translation: 公开了通过逆光谱光学相干断层扫描（ISOCT）测量和成像全部光散射特性的方法和系统。 组织被建模为具有连续折射率（RI）波动的介质，并且这种波动由RI相关函数描述。 通过测量组织的光学量（包括OCT光谱的散射功率，被定义为散射系数μ的比率的反射反照率α和背散射系数mub），RI相关函数可以被逆推并且全集 的光散射特性。