公开(公告)号：US11147865B2

公开(公告)日：2021-10-19

申请号：US16984499

申请日：2020-08-04

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Leena Shriram Bagle ,  Amardeep Singh Bhupender Bhalla ,  Miguel Angel Garcia ,  Lei Hu ,  Lakshmi Khandke ,  Avvari Krishna Prasad ,  Cindy Xudong Yang

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/39

Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

公开(公告)号：US11090375B2

公开(公告)日：2021-08-17

申请号：US16899738

申请日：2020-06-12

Applicant: Pfizer Inc.

Inventor： Emilio Anthony Emini ,  Wendy Jo Watson ,  Avvari Krishna Prasad ,  Mingming Han ,  Jin-Hwan Kim ,  Jianxin Gu ,  Yu-ying Yang ,  Rajesh Kumar Kainthan ,  David Cooper ,  Michael William Pride ,  Kathrin Ute Jansen

IPC: A61K39/09 ,  A61K47/64 ,  A61K39/00

Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US10821171B2

公开(公告)日：2020-11-03

申请号：US16242799

申请日：2019-01-08

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Philip Ralph Dormitzer ,  Alexey Vyacheslavovich Gribenko ,  Luke David Handke ,  Avvari Krishna Prasad ,  Xiayang Qiu ,  Mark Edward Ruppen ,  Xi Song ,  Kena Anne Swanson ,  Srinivas Kodali ,  Xin Xu ,  KariAnn Sweeney Efferen ,  Ping Cai ,  Kristin Rachael Tompkins ,  Lorna del Pilar Nunez

IPC: A61K39/155 ,  C07K14/135 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：US10745438B2

公开(公告)日：2020-08-18

申请号：US16505757

申请日：2019-07-09

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC: C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06 ,  A61K39/00

Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20190070283A1

公开(公告)日：2019-03-07

申请号：US16166708

申请日：2018-10-22

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Avvari Krishna Prasad ,  David Cooper ,  Wendy Jo Watson

IPC: A61K39/09 ,  A61K39/39 ,  A61K39/385 ,  A61K39/00

Abstract: The invention relates to isolated Streptococcus pneumoniae serotype 15B capsular polysaccharide and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 15B capsular polysaccharide covalently linked to a carrier protein, processes for their preparation and immunogenic compositions comprising them.

公开(公告)号：US20170224804A1

公开(公告)日：2017-08-10

申请号：US15347034

申请日：2016-11-09

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC: A61K39/095 ,  A61K39/09

CPC classification number: A61K39/095 ,  A61K39/092 ,  A61K45/06 ,  A61K47/64 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/627

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US11872274B2

公开(公告)日：2024-01-16

申请号：US17194224

申请日：2021-03-06

Applicant: Pfizer Inc.

Inventor： Emilio Anthony Emini ,  Wendy Jo Watson ,  Avvari Krishna Prasad ,  Mingming Han ,  Jin-Hwan Kim ,  Jianxin Gu ,  Yu-Ying Yang ,  Rajesh Kumar Kainthan ,  David Cooper ,  Michael William Pride ,  Kathrin Ute Jansen

IPC: A61K39/00 ,  A61K39/09 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/30

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20230355735A1

公开(公告)日：2023-11-09

申请号：US18338961

申请日：2023-06-21

Applicant: PFIZER INC.

Inventor： Jianxin Gu ,  Jin-hwan Kim ,  Avvari Krishna Prasad ,  Yu-ying Yang

IPC: A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K45/06

CPC classification number: A61K39/095 ,  A61K47/646 ,  A61K47/64 ,  A61K39/092 ,  A61K45/06 ,  A61K47/6415 ,  A61K2039/6068

Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20230203091A1

公开(公告)日：2023-06-29

申请号：US18176631

申请日：2023-03-01

Applicant: Pfizer Inc.

Inventor： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC: C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06

CPC classification number: C07K1/1077 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/092 ,  A61K47/646 ,  A61K47/6415 ,  A61K39/09 ,  C07H3/06 ,  A61K2039/6037

Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US11426456B2

公开(公告)日：2022-08-30

申请号：US17060337

申请日：2020-10-01

Applicant: Pfizer Inc.

Inventor： Jianxin Gu ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad ,  Yu-Ying Yang

IPC: A61K39/09 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00

Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.