公开(公告)号：US08175703B2

公开(公告)日：2012-05-08

申请号：US11338935

申请日：2006-01-25

Applicant: Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

Inventor： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

Abstract: Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

Abstract translation: 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

公开(公告)号：US08121685B2

公开(公告)日：2012-02-21

申请号：US12622602

申请日：2009-11-20

Applicant: Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

Inventor： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

IPC: A61N1/00

CPC classification number: A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

Abstract translation: 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

公开(公告)号：US08103345B2

公开(公告)日：2012-01-24

申请号：US12955218

申请日：2010-11-29

Applicant: Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

Inventor： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC: A61N1/365

CPC classification number: E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

Abstract translation: 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US08041426B2

公开(公告)日：2011-10-18

申请号：US12565344

申请日：2009-09-23

Applicant: Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

Inventor： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.

Abstract translation: 一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。 上述的心室延迟间隔可以优化患者心脏展示的搏动量。 上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。 这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

公开(公告)号：US08032214B2

公开(公告)日：2011-10-04

申请号：US12424136

申请日：2009-04-15

Applicant: Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

Inventor： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N1/3682

Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

Abstract translation: 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US07844330B2

公开(公告)日：2010-11-30

申请号：US11689646

申请日：2007-03-22

Applicant: Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

Inventor： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

IPC: A61N1/362

CPC classification number: A61N1/365

Abstract: A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.

Abstract translation: 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行MI重建控制。

公开(公告)号：US20100131026A1

公开(公告)日：2010-05-27

申请号：US12694124

申请日：2010-01-26

Applicant: Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/365

CPC classification number: A61N1/365 ,  A61N1/36592

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

Abstract translation: 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US07630764B2

公开(公告)日：2009-12-08

申请号：US11206394

申请日：2005-08-18

Applicant: Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

Inventor： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

IPC: A61N1/00

CPC classification number: A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

Abstract translation: 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

公开(公告)号：US07630763B2

公开(公告)日：2009-12-08

申请号：US11110418

申请日：2005-04-20

Applicant: Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

Inventor： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

IPC: A61B5/053 ,  A61B5/0295

CPC classification number: A61B5/0205 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686

Abstract: This document discusses, among other things, a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

Abstract translation: 本文件还讨论了包括测试模式和诊断模式的心脏功能管理装置或其它可植入医疗装置。 在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。 从每个这样的电极配置的阻抗数据计算至少一个品质因数。 在一个例子中，仅使用非心律失常节拍来计算品质因数。 使用品质因数自动选择特定的电极配置。 在诊断模式下，设备使用所选择的电极配置收集阻抗数据。 在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。 还描述了品质因数的其它实例。

公开(公告)号：US07457664B2

公开(公告)日：2008-11-25

申请号：US11125068

申请日：2005-05-09

Applicant: Yi Zhang ,  Yinghong Yu ,  Aaron R. McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Scott A. Meyer

Inventor： Yi Zhang ,  Yinghong Yu ,  Aaron R. McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Scott A. Meyer

IPC: A61N1/365

CPC classification number: A61N1/3712 ,  A61N1/3627 ,  A61N1/365 ,  G06F19/00

Abstract: Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

Abstract translation: 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。