公开(公告)号：US20230128537A1

公开(公告)日：2023-04-27

申请号：US18084394

申请日：2022-12-19

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/04 ,  A61N1/36

Abstract: Devices, systems and methods are disclosed for treating or preventing a developmental disorder, such as attention-deficit hyperactivity disorder (ADHD), an autism spectrum disorder, Asperger syndrome, childhood disintegrative disorder, overactive disorder, pervasive developmental disorder. A device comprises an electrode having a contact surface for contacting an outer skin surface of a patient and a power source coupled the electrode. The power source generates and transmits an electrical impulse having a frequency of about 1 kHz to about 20 kHz through the contact surface and the outer skin surface to a nerve within the patient. The electrical impulse is sufficient to modify the behavioral disorder in the patient.

公开(公告)号：US20220347471A1

公开(公告)日：2022-11-03

申请号：US17858151

申请日：2022-07-06

Applicant: ELECTROCORE, INC

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  A61N1/40 ,  A61N1/04 ,  A61N2/00

Abstract: Systems and methods are provided for modulating one or more nerves within patients. A method comprises generating a signal comprising an electrical impulse and contacting an interface with an outer skin surface of a patient. The electrical impulse is delivered from one or more electrode(s) through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve sufficiently to treat a medical condition. The one or more electrode(s) are spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.

公开(公告)号：US11298535B2

公开(公告)日：2022-04-12

申请号：US17220805

申请日：2021-04-01

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  G16H20/30 ,  G06Q10/10 ,  G16H20/40 ,  G16H40/20 ,  A61N1/372 ,  A61N1/04 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  A61B5/00

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that applies an electrical impulse transcutaneously through an outer skin surface of the patient. The electrical impulse includes pulses having a frequency of about 1 kHz to about 20 kHz. The device housing may transmit data to or from a patient interface device, such as a mobile phone or computer, relating to the stimulation parameters. The interface device in turn may communicate with a database contained within other computers, via a network or the internet.

公开(公告)号：US11197998B2

公开(公告)日：2021-12-14

申请号：US16535624

申请日：2019-08-08

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  G16H20/30 ,  G06Q10/10 ,  G16H20/40 ,  G16H40/20 ,  A61N1/372 ,  A61N1/04 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  A61B5/00

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.

公开(公告)号：US11179560B2

公开(公告)日：2021-11-23

申请号：US16284852

申请日：2019-02-25

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/04 ,  A61N1/362 ,  A61N1/36 ,  A61N1/375 ,  A61N2/00 ,  A61N2/02

Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.

公开(公告)号：US20200222708A1

公开(公告)日：2020-07-16

申请号：US16830607

申请日：2020-03-26

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle ,  Steven Mendez

IPC: A61N2/00 ,  A61H23/00 ,  A61H23/02 ,  A61H31/00 ,  A61H39/00 ,  A61N1/36 ,  A61N1/40 ,  A61N2/02 ,  A61N5/06 ,  A61N1/375 ,  A61N1/378 ,  A61N7/00

Abstract: Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods incluce positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The the electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.

公开(公告)号：US20200046976A1

公开(公告)日：2020-02-13

申请号：US16598127

申请日：2019-10-10

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  A61N2/00 ,  A61N2/02 ,  A61N1/40

Abstract: Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of a selected nerve at the target region to inhibit inflammation, enhance an anti-inflammatory competence of a cytokine in the patient and treat the neurodegenerative disorder. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.

公开(公告)号：US20200001083A1

公开(公告)日：2020-01-02

申请号：US16540476

申请日：2019-08-14

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  A61N1/04 ,  A61N2/00

Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

公开(公告)号：US20190240486A1

公开(公告)日：2019-08-08

申请号：US16388392

申请日：2019-04-18

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  A61N2/00 ,  A61N2/02 ,  A61N1/40

CPC classification number: A61N1/36025 ,  A61N1/36114 ,  A61N1/40 ,  A61N2/002 ,  A61N2/006 ,  A61N2/02

Abstract: Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and/or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium. Reduction in inflammation is effected by enhancing the anti-inflammatory competence of cytokines such as TGF-beta, wherein a retinoid or components of the retinoic acid signaling system provide an anti-inflammatory bias, by enhancing anti-inflammatory activity of a neurotrophic factor such as NGF, GDNF, BDNF, or MANF, and/or by inhibiting the activity of pro-inflammatory cytokines such as TNF-alpha.

公开(公告)号：US20190209839A1

公开(公告)日：2019-07-11

申请号：US16284852

申请日：2019-02-25

Applicant: ElectroCore, Inc.

Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC: A61N1/36 ,  A61N2/00 ,  A61N2/02

CPC classification number: A61N1/36014 ,  A61N1/0456 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36171 ,  A61N1/36178 ,  A61N1/362 ,  A61N1/3625 ,  A61N1/375 ,  A61N2/006 ,  A61N2/02

Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.