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公开(公告)号：US20050109951A1
公开(公告)日：2005-05-26
申请号：US10500186
申请日：2002-12-26
Applicant: Falk Fish , Zvi Greenberg , Ouriel Faktor
Inventor： Falk Fish , Zvi Greenberg , Ouriel Faktor
CPC classification number: G01N21/645 , G01N21/64 , G01N21/8483 , G01N33/549 , G01N2021/6439 , G01N2021/757 , G01N2021/7759 , G01N2021/7763 , G01N2021/7786 , G01N2201/0221 , G01N2201/0222 , G01N2201/0245 , G01N2201/062 , G01N2201/0628
Abstract: A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.
Abstract translation: 用于便携式荧光检测的装置，系统和方法。 本发明的便携式装置具有低功率光，其中波长范围被定义为至少一个波长的光。 光源优选地是高能量的，使得消耗的大部分电功率然后被转换成透射光。 然后优选用任何低成本和低功率光电检测器检测来自激发的荧光团的发射光。 尽管可选地使用高灵敏度的光学检测器，但是优选地，例如使用诸如常规光电二极管或CCD（电荷耦合器件）传感器的任何光感测装置来检测荧光。
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公开(公告)号：US20040038390A1
公开(公告)日：2004-02-26
申请号：US10440719
申请日：2003-05-19
Inventor： Steven J. Boege , Mark F. Oldham , Eugene F. Young
IPC: C12M001/34
CPC classification number: G01N21/6452 , B01L7/52 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0628 , G01N2201/0635 , Y10S435/808
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.
Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。
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公开(公告)号：US12025564B2
公开(公告)日：2024-07-02
申请号：US18312873
申请日：2023-05-05
Applicant: The Boeing Company
Inventor： Morteza Safai
IPC: G01N21/88 , B29C64/371 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , G01N21/95
CPC classification number: G01N21/8806 , B29C64/371 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , G01N21/8851 , G01N21/95 , G01N2201/06113 , G01N2201/0627 , G01N2201/0628
Abstract: A method for real-time surface imperfection detection for additive manufacturing and 3-D printing parts is provided. The method includes directing a first light radiation using one or more illumination sources, wherein the first light radiation illuminates a target area of a part being manufactured in a uniform chromatic light such that the target area appears to have a substantially uniform monochromatic color; capturing a current image of a second light radiation that is scattered or reflected by the target area using one or more feedback cameras; and analyzing the current image of the second light radiation using at least one of the one or more feedback camera with a previously acquired image to determine whether a surface imperfection exists or does not exist.
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公开(公告)号：US20180340889A1
公开(公告)日：2018-11-29
申请号：US16036646
申请日：2018-07-16
Applicant: Lester F. LUDWIG
Inventor： Lester F. LUDWIG , Karen HAO , Frank HU , Alice HUANG , Pooncharas TIPGUNLAKANT
IPC: G01N21/59 , G01N15/14 , G01N21/25 , G01N21/51 , G01N21/53 , G01N21/64 , G01N15/02 , G01N15/10 , G01N21/17
CPC classification number: G01N21/59 , G01N15/0227 , G01N15/1434 , G01N15/1459 , G01N15/1475 , G01N15/1484 , G01N21/253 , G01N21/51 , G01N21/534 , G01N21/6452 , G01N21/6458 , G01N2015/0294 , G01N2015/1006 , G01N2015/1445 , G01N2015/1493 , G01N2015/1497 , G01N2021/1787 , G01N2201/062 , G01N2201/0626 , G01N2201/0628
Abstract: Optical tomography arrangements are disclosed for performing optical tomography on the transparent or translucent contents of individual microplate wells comprising a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. The light emitting elements can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise organic light sensing devices, photodiodes, phototransistors, CMOS photodetectors, or charge-coupled devices (CCDs). The light emitting array can be flat or curved, and the light sensing array can be flat or curved. The collection of measurement values can be overspecified, and a generalized inverse operation can provide solutions rendering computational tomography data.
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35.发明授权公开(公告)号：US09719925B2
公开(公告)日：2017-08-01
申请号：US14741319
申请日：2015-06-16
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
CPC classification number: G01N21/6428 , B01L7/52 , B01L2300/1805 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/062 , G01N2201/0627 , G01N2201/0628 , Y10S435/808
Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
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Patent Agency Ranking
公开(公告)号：US09429521B2
公开(公告)日：2016-08-30
申请号：US14404338
申请日：2013-05-30
Inventor： David Kramer , Jeffrey Cruz , Christopher Hall , William Kent Kovac , Robert Zegarac
CPC classification number: G01N21/6486 , G01N21/6408 , G01N21/6456 , G01N33/0098 , G01N33/025 , G01N2021/635 , G01N2021/8466 , G01N2201/0221 , G01N2201/0627 , G01N2201/0628
Abstract: Chlorophyll fluorescence may be studied in response to a variety of environmental cues or conditions by growing phototrophic organisms under actinic illumination. Such illumination may be punctuated or disrupted to gain information about the photosynthetic properties or performance of the phototrophic organism. Instruments or devices for carrying out the method are also described.
Abstract translation: 可以通过在光化照射下生长光养生物来响应各种环境线索或条件来研究叶绿素荧光。 这种照明可能被打断或破坏以获得关于光合生物的光合性质或性能的信息。 还描述了用于执行该方法的仪器或装置。
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公开(公告)号：US20160216192A1
公开(公告)日：2016-07-28
申请号：US14916743
申请日：2013-09-05
Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
Inventor： Yansong Gu
CPC classification number: G01N15/0205 , G01N15/1434 , G01N15/1468 , G01N21/6486 , G01N33/5008 , G01N2015/1006 , G01N2015/1493 , G01N2201/0628 , G02B21/06 , G02B21/26 , H05B33/0896
Abstract: Cell culturing and tracking systems using an array of organic light emitting diodes (OLEDs) to illuminate cells and/or other particles in a cell chamber are described. Compared to conventional light sources, the OLED array consumes very little energy and emits a small amount of waste heat, so it may be disposed near or on the cell chamber. For instance, it can be printed on one side of the cell chamber itself. In addition, the OLED array may be patterned into pixels or sub-pixels (individual OLEDs), each of which is as small as or smaller than an individual cell or particle. Because the pixels are so small, OLED illumination can be used to acquire images with a spatial resolution equal to or better than the cell or particle cell. As a result, the OLED array can be used to track, monitor, identify, and manipulate individual cells within the cell culture.
Abstract translation: 描述了使用有机发光二极管（OLED）阵列来照射细胞室中的细胞和/或其他颗粒的细胞培养和跟踪系统。 与常规光源相比，OLED阵列消耗的能量很少，并且会排放少量的余热，因此它可以靠近或放置在电池室上。 例如，它可以印刷在电池室本身的一侧。 此外，OLED阵列可以被图案化成像素或子像素（单独的OLED），其每一个都小于或小于单个单元或颗粒。 由于像素非常小，可以使用OLED照明来获取空间分辨率等于或优于单元格或粒子单元的图像。 结果，OLED阵列可用于跟踪，监测，识别和操纵细胞培养物中的各个细胞。
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公开(公告)号：US20130143310A1
公开(公告)日：2013-06-06
申请号：US13748508
申请日：2013-01-23
Applicant: Applied Biosystems, LLC
Inventor： Mark F. Oldham , Eugene F. Young
IPC: G01N21/64
CPC classification number: G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
Abstract translation: 提供了可以监测核酸序列扩增反应的仪器，例如DNA和DNA片段的PCR扩增。 仪器包括沿激发光束路径和发射光束路径中的一个或两个设置的多陷波滤波器。 还提供了使用包括沿着光束路径设置的多陷波滤波器的仪器来监测核酸序列扩增的方法。
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公开(公告)号：US08435797B2
公开(公告)日：2013-05-07
申请号：US12961675
申请日：2010-12-07
Applicant: Vincent P. Schnee
Inventor： Vincent P. Schnee
CPC classification number: G01N21/66 , G01N21/77 , G01N33/22 , G01N2201/0628 , Y10T436/17 , Y10T436/170769 , Y10T436/173076
Abstract: A senor uses a transduction mechanism of attenuating electroluminescence. Luminescence from a light emitting diode is attenuated as a consequence of direct interaction of an analyte and a electroluminescent material, An electroluminescent diode sensor (EDS) is fabricated in a way that allows the electroluminescent material in the diode to be exposed to gaseous, liquid or solid sample(s) which may affect the luminescence intensity of the diode.
Abstract translation: 传声器使用衰减电致发光的转导机制。 来自发光二极管的发光作为分析物和电致发光材料的直接相互作用的结果被衰减。电致发光二极管传感器（EDS）以允许二极管中的电致发光材料暴露于气体，液体或 可能影响二极管发光强度的固体样品。
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公开(公告)号：US20130011848A1
公开(公告)日：2013-01-10
申请号：US13611462
申请日：2012-09-12
Applicant: Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
Inventor： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
CPC classification number: G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。 光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。 根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。 还提供了使用光学仪器的分析方法。
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