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    Recovery of tocopherols
    31.
    发明授权
    Recovery of tocopherols 失效

    公开(公告)号：US5670669A

    公开(公告)日：1997-09-23

    申请号：US654441

    申请日：1996-05-28

    Applicant: Tracy K. Hunt

    Inventor： Tracy K. Hunt

    IPC: B01J31/02 ,  B01J31/08 ,  C07C67/03 ,  C07C67/54 ,  C07D311/72

    CPC classification number: C07D311/72 ,  C07C67/03 ,  C07C67/54

    Abstract: Starting from a mixture containing tocopherol, fats and/or fat derivatives, more particularly fatty acids, and optionally sterol and/or sterol derivatives, the free fatty acids present in the mixture are esterified with an alcohol. The mixture is then transesterified with an alcohol in the presence of a basic catalyst. After the transesterification, the excess lower alcohol is distilled off from the reaction mixture. The transesterification catalyst and the glycerol present, if any, are removed and the fatty acid alkyl ester is distilled off from the mixture. Distillation of fatty acid alkyl esters can be accomplished with a packed column in sequence with a wiped film evaporator. The simultaneous recovery of tocopherol and sterol is possible. Tocopherols and sterols can be separated by the crystallization of sterols from a blend of organic solvents.

    Oxidation of organosulphur compounds
    32.
    发明授权
    Oxidation of organosulphur compounds 失效
    有机硫化合物的氧化

    公开(公告)号：US5621097A

    公开(公告)日：1997-04-15

    申请号：US553009

    申请日：1995-11-03

    Applicant: Scott W. Brown ,  Angela M. Lee ,  Stephen C. Oakes

    Inventor： Scott W. Brown ,  Angela M. Lee ,  Stephen C. Oakes

    IPC: B01J27/188 ,  B01J31/08 ,  C07C303/16 ,  C07C309/29 ,  C07C315/02 ,  C07D499/00 ,  C07D499/46 ,  C07D499/48

    CPC classification number: C07D499/00 ,  B01J27/188 ,  B01J31/08 ,  C07C303/16 ,  C07C315/02 ,  B01J2231/70 ,  Y02P20/582

    Abstract: A process for the oxidation of organosulphur compounds with hydrogen peroxide is provided. The process employs solid supported polyacids comprising tungsten, molybdenum and/or vanadium as catalysts. The supports are selected from compounds, preferably oxides, of Group IIa, IIb, IIIb, IVa and IVb elements, and strong base ion exchange resins. Certain embodiments of the process provide for the oxidation of sulphides to sulphoxides or sulphones, particularly for the oxidation of penicillins to penicillin sulphoxides. Other embodiments of the process provide for the selective oxidation of thiols to sulphoxides.

    Abstract translation: 提供了一种用过氧化氢氧化有机硫化合物的方法。 该方法使用包含钨，钼和/或钒的固体负载的多元酸作为催化剂。 载体选自IIa，IIb，IIIb，IVa和IVb族元素的化合物，优选氧化物，以及强碱离子交换树脂。 该方法的某些实施方案提供了硫化物氧化成亚砜或砜，特别是将青霉素氧化成青霉素亚砜。 该方法的其它实施方案提供硫醇选择性氧化成亚砜。

    Method of using liquid column packing materials
    33.
    发明授权
    Method of using liquid column packing materials 失效
    液柱包装材料的使用方法

    公开(公告)号：US5559039A

    公开(公告)日：1996-09-24

    申请号：US292520

    申请日：1994-08-18

    Applicant: Dwight E. Williams

    Inventor： Dwight E. Williams

    IPC: B01J20/32 ,  B01J31/02 ,  B01J31/08 ,  G01N30/02

    CPC classification number: B01J20/287 ,  B01J20/28078 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3282 ,  B01J31/0254 ,  B01J31/08 ,  B01J2220/54 ,  B01J2220/58 ,  Y10S530/811 ,  Y10S530/812

    Abstract: Packing materials for liquid chromatographic or catalytic columns are prepared by contacting a porous protein-adsorptive particulate or membranous support, such as a porous silica particulate support, with an aqueous solution into which a protein has been dissolved to form a saturated coating of protein on the external surfaces of the porous protein-adsorptive support, removing excess protein that remains in solution by washing, and, then crosslinking the protein in the coating. The result is a packing material which resists further adsorption by many different proteins but which continues to provide the adsorptive or catalytic properties of the groups on the internal surfaces of the porous protein-adsorptive support for separations, analysis, or alteration of small molecules. The packing material of the present invention is particularly useful in HPLC or solid phase extraction columns for direct injection drug analysis in plasma, serum, and urine.

    Abstract translation: 用于液相色谱或催化色谱柱的包装材料是通过将多孔蛋白质吸附性颗粒或膜状载体如多孔二氧化硅颗粒载体与溶解有蛋白质的水溶液接触形成蛋白质的饱和涂层而制备的 多孔蛋白质吸附载体的外表面，通过洗涤去除残留在溶液中的多余蛋白质，然后在涂层中交联蛋白质。 结果是一种包装材料，其抵抗许多不同蛋白质的进一步吸附，但是继续提供多孔蛋白质 - 吸附载体的内表面上的基团的吸附或催化性质用于分离，分析或改变小分子。 本发明的包装材料在用于血浆，血清和尿液中的直接注射药物分析的HPLC或固相萃取柱中特别有用。

    Liquid column packing materials and method for making the same
    34.
    发明授权
    Liquid column packing materials and method for making the same 失效
    液柱包装材料及其制造方法

    公开(公告)号：US5545317A

    公开(公告)日：1996-08-13

    申请号：US422803

    申请日：1995-04-17

    Applicant: Dwight E. Williams

    Inventor： Dwight E. Williams

    IPC: B01J20/32 ,  B01J31/02 ,  B01J31/08 ,  B01D15/08

    CPC classification number: B01J20/287 ,  B01J20/28078 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3282 ,  B01J31/0254 ,  B01J31/08 ,  B01J2220/54 ,  B01J2220/58 ,  Y10S530/811 ,  Y10S530/812

    Abstract: Packing materials for liquid chromatographic or catalytic columns are prepared by contacting a porous protein-adsorptive particulate or membranous support, such as a porous silica particulate support, with an aqueous solution into which a protein has been dissolved to form a saturated coating of protein on the external surfaces of the porous protein-adsorptive support, removing excess protein that remains in solution by washing, and, then crosslinking the protein in the coating. The result is a packing material which resists further adsorption by many different proteins but which continues to provide the adsorptive or catalytic properties of the groups on the internal surfaces of the porous protein-adsorptive support for separations, analysis, or alteration of small molecules. The packing material of the present invention is particularly useful in HPLC or solid phase extraction columns for direct injection drug analysis in plasma, serum, and urine.

    Abstract translation: 用于液相色谱或催化色谱柱的包装材料是通过将多孔蛋白质吸附性颗粒或膜状载体如多孔二氧化硅颗粒载体与溶解有蛋白质的水溶液接触形成蛋白质的饱和涂层而制备的 多孔蛋白质吸附载体的外表面，通过洗涤去除残留在溶液中的多余蛋白质，然后在涂层中交联蛋白质。 结果是一种包装材料，其抵抗许多不同蛋白质的进一步吸附，但是继续提供多孔蛋白质 - 吸附载体的内表面上的基团的吸附或催化性质用于分离，分析或改变小分子。 本发明的包装材料在用于血浆，血清和尿液中的直接注射药物分析的HPLC或固相萃取柱中特别有用。

    Process for preparing a bisphenol
    37.
    发明授权
    Process for preparing a bisphenol 失效
    制备双酚的方法

    公开(公告)号：US5288926A

    公开(公告)日：1994-02-22

    申请号：US13603

    申请日：1993-02-04

    Applicant: Emil Patrascu ,  Dieter Tank ,  Jochen Gressmann ,  Johann-Wilhelm Frey ,  Ulrich Wallbaum

    Inventor： Emil Patrascu ,  Dieter Tank ,  Jochen Gressmann ,  Johann-Wilhelm Frey ,  Ulrich Wallbaum

    IPC: B01J31/08 ,  B01J31/10 ,  C07B61/00 ,  C07C37/20 ,  C07C37/82 ,  C07C39/16

    CPC classification number: C07C37/20 ,  C07C37/82 ,  Y02P20/52

    Abstract: Bisphenols are prepared bya) reacting a phenolic compound with a carbonyl compound in a reaction mixture, containing the carbonyl compound, a stoichiometric excess of the phenolic compound and a catalyst, to produce a product mixture containing a bisphenol,b) separating bisphenol from the product mixture to leave a mother liquor andc) recycling at least a portion of the mother liquor to the reaction mixture.At least a portion of the phenolic compound is contacted with a strongly acidic cation exchange resin and a strongly basic anion exchange resin before the phenolic compound is used in the reaction step a) and/or at least a portion of the product mixture and/or at least a portion or the mother liquor is contacted with a strongly acidic cation exchange resin and a strongly basic anion exchange resin before mother liquor is recycled to the reaction mixture.

    Abstract translation: 双酚通过以下方法制备：a）在含有羰基化合物，化学计量过量的酚类化合物和催化剂的反应混合物中使酚类化合物与羰基化合物反应，制备含双酚的产物混合物，b）将双酚与 产品混合物以留下母液，和c）将至少一部分母液再循环到反应混合物中。 在酚类化合物在反应步骤a）和/或至少一部分产物混合物中使用之前，至少部分酚类化合物与强酸性阳离子交换树脂和强碱性阴离子交换树脂接触，和/或 在母液再循环到反应混合物中之前，至少一部分或母液与强酸性阳离子交换树脂和强碱性阴离子交换树脂接触。

    Method for the production of 1,3-propandiol
    39.
    发明授权
    Method for the production of 1,3-propandiol 失效
    1,3-丙二醇的生产方法

    公开(公告)号：US5171898A

    公开(公告)日：1992-12-15

    申请号：US798225

    申请日：1991-11-27

    Applicant: Dietrich Arntz ,  Norbert Wiegand

    Inventor： Dietrich Arntz ,  Norbert Wiegand

    IPC: B01J31/08 ,  C07B61/00 ,  C07C29/04 ,  C07C29/14 ,  C07C29/141 ,  C07C31/20 ,  C07C45/64

    CPC classification number: C07C29/141 ,  C07C45/64

    Abstract: The hydration of acrolein in the presence of a chelate-forming ion exchange resin based on polystyrene/divinyl benzene as catalyst and on the subsequent hydrogenation of the reaction mixture freed of the non-reacted acrolein and containing 3-hydroxypropionaldehyde is disclosed. As a result of using chelate-forming ion exchangers with anchor groups of the formula ##STR1## in which Z=H, C.sub.1 -C.sub.6 -alkyl, --CH.sub.2 --CH(CH.sub.3)--Y' or --(CH.sub.2).sub.o --Y' and Y and/or Y'=--COOH, --OH, pyridyl or --P(O)(CH.sub.2 OH)OH, the hydration occurs at lower temperatures with a greater space-time yield and especially a greater selectivity than when using previously known ion exchangers. Resins with methylene imino diacetic acid anchor groups in the H form or partially doped with alkali-, alkaline-earth or earth-metal ions are especially suitable.

    Abstract translation: 公开了在基于聚苯乙烯/二乙烯基苯作为催化剂的螯合形成离子交换树脂存在下丙烯醛的水合，然后在无反应的丙烯醛和含有3-羟基丙醛的反应混合物的随后氢化中进行水合。 作为使用螯合形成离子交换剂，其结构式为“IMAGE”的锚定基团，其中Z = H，C 1 -C 6 - 烷基，-CH 2 -CH（CH 3）-Y'或 - （CH 2）o Y'和Y 和/或Y'= -COOH，-OH，吡啶基或-P（O）（CH 2 OH）OH时，水合在较低的温度下发生，具有比使用先前已知的离子交换剂更大的空时收率，特别是更大的选择性。 具有H形式的亚甲基亚氨基二乙酸锚定基团或部分掺杂有碱金属，碱土金属或土金属离子的树脂是特别合适的。

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