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    Process for removal of impurities in alkyl nitrite formation
    32.
    发明授权
    Process for removal of impurities in alkyl nitrite formation 失效
    去除亚硝酸烷基酯形成中的杂质的方法

    公开(公告)号：US4879401A

    公开(公告)日：1989-11-07

    申请号：US102370

    申请日：1987-09-29

    Applicant: Arthur R. Doumaux, Jr. ,  James R. Nelson

    Inventor： Arthur R. Doumaux, Jr. ,  James R. Nelson

    IPC: C07C201/16 ,  C07C67/00 ,  C07C201/00 ,  C07C201/04 ,  C07C203/00 ,  C07C203/02 ,  C07C203/04

    CPC classification number: C07C201/04

    Abstract: A process is provided for removing impurities from the gaseous product of an alkyl nitrite production zone by contacting a portion of it with lower alcohol and oxygen to convert substantially all of the nitric oxide in that portion of the gaseous product stream to alkyl nitrite, the oxygen being present in an amount such that the mole ratio of nitric oxide to oxygen is in the range of about 4:1 to about 2:1 and the lower alcohol being present in the reaction zone such that the mole ratio of nitric oxide to lower alcohol is about 1:1 or less. A recovery stream, comprising alkyl nitrite substantially free of nitric oxide, is withdrawn from the reaction zone and at least a portion of the alkyl produced in the reaction zone is removed. A least a portion of the balance of the recovery stream from which the alkyl nitrite has been removed is purged, thereby removing impurities from the process.

    Abstract translation: 提供了一种通过使其一部分与低级醇和氧接触而从亚硝酸烷基酯生产区的气态产物中除去杂质的方法，以将该部分气态产物流中的所有一氧化氮转化为亚硝酸烷基酯，氧气 存在的量使得一氧化氮与氧的摩尔比在约4:1至约2:1的范围内，低级醇存在于反应区中，使得一氧化氮与低级醇的摩尔比 约为1：1或更少。 包含基本上不含一氧化氮的亚硝酸烷基酯的回收流从反应区中排出，并且除去反应区中产生的烷基的至少一部分。 将亚硝酸烷基酯从其中除去的回收料流的余量的至少一部分被清除，从而从该方法中除去杂质。

    5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them
    37.
    发明授权
    5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them 失效
    5-芳基烷基-4-烷氧基-2（5H） - 呋喃酮，其制备方法及其制备方法和含有它们的药物

    公开(公告)号：US4855320A

    公开(公告)日：1989-08-08

    申请号：US46586

    申请日：1987-05-04

    Applicant: Shyam S. Chatterjee ,  Klaus Klessing

    Inventor： Shyam S. Chatterjee ,  Klaus Klessing

    IPC: C07D307/56 ,  A61K31/341 ,  A61K31/365 ,  A61P25/08 ,  B01J23/46 ,  C07C51/353 ,  C07C59/64 ,  C07C67/00 ,  C07C67/30 ,  C07C69/734 ,  C07C201/00 ,  C07C205/56 ,  C07D307/60

    CPC classification number: C07C59/64 ,  C07D307/60

    Abstract: The present invention provides 5-arylalkyl-4-alkoxy-2(5H)-furanones of the formula: ##STR1## wherein the oxygen atoms on C-5 and C-.alpha., relative to one another, are in the threo-position, with the exclusion of those compounds of the formula (I) wherein R.sup.2 is H or CH.sub.3 when n=0 or 2, R.sup.o =H, R.sup.1 =CH.sub.3, R.sup.3 =H and R.sup.4 =H.The present invention also provides processes for their preparation, as well as new 3-alkoxy-5-(subst.)-phenyl-2(E), 4(E)-pentadienoates as reactive intermediates for the preparation of the new furanone derivatives.The new furanone derivatives of the threo series are active as anticonvulsives/anti-epileptics. Therefore, the present invention also provides medicaments which contain these new furanone derivatives, as well as known furanones, the anticonvulsive/anti-epileptic effectiveness of which has been found for the first time.

    Abstract translation: 本发明提供下式的5-芳基烷基-4-烷氧基-2（5H） - 呋喃酮：其中C-5和C-α上的氧原子相对于彼此处于苏打 位置，排除那些当n = 0或2时R 2为H或CH 3的式（I）化合物，Ro = H，R 1 = CH 3，R 3 = H和R 4 = H。 本发明还提供其制备方法，以及作为制备新的呋喃酮衍生物的反应中间体的新的3-烷氧基-5-（低级） - 苯基-2（E），4（E） - 戊二酸二乙酯。 苏氨酸系列的新呋喃酮衍生物作为抗惊厥药/抗癫痫药物是有活性的。 因此，本发明还提供含有这些新的呋喃酮衍生物的药物以及已知的呋喃酮，其首次发现其抗惊厥/抗癫痫效果。

    Dispirotetradecanes
    38.
    发明授权
    Dispirotetradecanes 失效

    公开(公告)号：US4853151A

    公开(公告)日：1989-08-01

    申请号：US112356

    申请日：1987-08-11

    Applicant: Fritz Vogtle ,  Wolfgang Calaminus

    Inventor： Fritz Vogtle ,  Wolfgang Calaminus

    IPC: C07C43/115 ,  C07C13/547 ,  C07C13/72 ,  C07C17/00 ,  C07C17/18 ,  C07C17/26 ,  C07C23/18 ,  C07C25/18 ,  C07C41/00 ,  C07C43/18 ,  C07C45/00 ,  C07C49/04 ,  C07C49/385 ,  C07C49/453 ,  C07C49/483 ,  C07C49/517 ,  C07C49/657 ,  C07C49/675 ,  C07C49/697 ,  C07C49/753 ,  C07C67/00 ,  C07C69/02 ,  C07C69/753 ,  C07C201/00 ,  C07C253/00 ,  C07C255/45 ,  C07C325/00 ,  C07D319/06 ,  C07D339/08 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  G02F1/13

    CPC classification number: C07C255/00 ,  C07C13/72 ,  C07C23/18 ,  C07C49/453 ,  C07C49/483 ,  C07C49/517 ,  C07C49/675 ,  C07C49/697 ,  C07C49/753 ,  C09K19/32

    Abstract: Dispirotetradecanes of the formula I ##STR1## wherein R.sup.1 and R.sup.2 are each independently of each other alkyl containing 1 to 12 carbon atoms wherein one or more non-adjacent CH.sub.2 groups may also be replaced by --O--, --CO--, --CO--O--, --O--CO--, --O--COO-- and/or --CH.dbd.CH-- (trans), one of the radicals R.sup.1 and R.sup.2 also being H, F, Cl, Br, I, CN, NO.sub.2, NCS,A.sup.1 and A.sup.2 are each independently of each other trans-1,4-cyclohexylene wherein one or two non-adjacent CH.sub.2 groups may be replaced by --O-- and/or --S--, or 1,4-phenylene wherein one or more CH groups may also be replaced by N, with it also being possible optionally for A.sup.1 and A.sup.2 to be substituted laterally or axially by F, Cl, CN, CH.sub.3,Z.sup.1 and Z.sup.2 are each independently of each other --C--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 -- or a single bond,m and n are each 0, 1 or 2,(m+n) 0, 1 or 2,X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are each independently of each other H, F, Cl or CN, and one or both of the groups CX.sup.1 X.sup.2 and CX.sup.3 X.sup.4 may also be C.dbd.O, may be used as components of liquid-crystalline phases.

    Abstract translation: PCT No.PCT / EP86 / 00722 Sec。 371日期1987年8月11日 102（e）日期1987年8月11日PCT提交1986年12月8日PCT公布。 公开号WO87 / 03581 日期：1987年6月18日。式I的对映异十四烷酮其中R 1和R 2各自独立地为彼此具有1至12个碳原子的烷基，其中一个或多个不相邻的CH 2基团也可被-O- ，-CO-，-CO-O-，-O-CO-，-O-COO-和/或-CH = CH-（反式），基团R1和R2之一也是H，F，Cl，Br ，I，CN，NO 2，NCS，A 1和A 2各自独立地为彼此反式-1,4-亚环己基，其中一个或两个不相邻的CH 2基可以被-O-和/或-S-或1 其中一个或多个CH基团也可以被N代替的4-亚苯基，也可以任选地使A1和A2被F，B，CN，CH 3，Z 1和Z 2各自独立地取代为横向或轴向被F，Cl，CN， 其它-CO-，-O-CO-，-CH2CH2-，-CH2O-，-OCH2-或单键，m和n分别为0,1或2，（m + n）0,1或2，X1 ，X2，X3和X4各自独立地为H，F，Cl或CN，并且基团CX1X2和CX3X4中的一个或两个也可以是C = O，可以用作组分 的液晶相。

    Process for the preparation of 2,4-dinitrophenyl ethers
    39.
    发明授权
    Process for the preparation of 2,4-dinitrophenyl ethers 失效
    2,4-二硝基苯醚的制备方法

    公开(公告)号：US4847426A

    公开(公告)日：1989-07-11

    申请号：US198285

    申请日：1988-05-25

    Applicant: Dieter Heck ,  Hartmut Heise ,  Manfred Hintzmann

    Inventor： Dieter Heck ,  Hartmut Heise ,  Manfred Hintzmann

    IPC: C07C205/38 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/31 ,  C07C205/37

    CPC classification number: C07C201/12

    Abstract: A process for the preparation of 2,4-dinitrophenyl ethers of the general formula (1) ##STR1## in which R denotes an alkyl(C.sub.1 -C.sub.6) or alkoxy(C.sub.1 -C.sub.4)alky(C.sub.1 -C.sub.4) group by reacting 1 mole of 2,4-dinitrochlorobenzene in the anhydrous alcohol which is required for the ether formation and is of the general formula (2)R--OH (2)in which R has the abovementioned meaning, in the presence of 1.0 to 3.0 mole of an anhydrous alkali metal carbonate, at temperatures of 20.degree. C. to 150.degree. C., where appropriate under pressure.

    Abstract translation: 一种制备通式（1）的2,4-二硝基苯基醚的方法，其中R表示烷基（C1-C6）或烷氧基（C1-C4）烷基（C1-C4）基团 通过使1摩尔2,4-二硝基氯苯在醚形成所需的无水醇中反应，并具有通式（2）R-OH（2），其中R具有上述含义，在1.0〜 3.0摩尔无水碱金属碳酸盐，温度为20℃至150℃，适当时在压力下。

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