公开(公告)号：US20060154861A1

公开(公告)日：2006-07-13

申请号：US11257107

申请日：2005-10-25

Applicant: Akemichi Baba ,  Hitoshi Hashimoto ,  Norihito Shintani ,  Yukihiko Sugimoto

Inventor： Akemichi Baba ,  Hitoshi Hashimoto ,  Norihito Shintani ,  Yukihiko Sugimoto

IPC: A61K38/22

CPC classification number: G01N33/507 ,  A61K38/2278 ,  A61K45/06 ,  G01N33/5088 ,  A61K2300/00

Abstract: There are provided PACAP which is a substance capable of inhibiting the hyperplasia of pancreatic cells and/or the hypersecretion of insulin by pancreatic cells, a method for inhibiting the hyperplasia of pancreatic cells and/or the hypersecretion of insulin by pancreatic cells in a human by PACAP administration, a pharmaceutical composition containing PACAP and, optionally, an anti-diabetic agent, and a method for evaluating a substance capable of inhibiting the hyperplasia of pancreatic cells and/or the hypersecretion of insulin by pancreatic cells relying on the expression of Reg IIIβ to be stimulated by PACAP as an index.

Abstract translation: 提供了PACAP，其是能够抑制胰腺细胞增生和/或胰腺细胞分泌胰岛素的物质，抑制胰腺细胞增生的方法和/或胰腺胰腺细胞在人类中的过度分泌的方法 PACAP给药，含有PACAP的药物组合物和任选的抗糖尿病药物，以及依赖于Reg IIIbeta的表达来评估能够抑制胰腺细胞增生和/或胰腺胰岛素过度分泌的物质的方法 被PACAP刺激为指标。

公开(公告)号：US20060104849A1

公开(公告)日：2006-05-18

申请号：US10541641

申请日：2003-12-17

Applicant: Shuji Tada ,  Zheng Sun ,  Hitoshi Hashimoto ,  Toshihiko Abe

Inventor： Shuji Tada ,  Zheng Sun ,  Hitoshi Hashimoto ,  Toshihiko Abe

IPC: B22F3/105

CPC classification number: B22F3/105

Abstract: A method of performing direct current pressurized sintering to powder in a mold having a cylindrical molding space, wherein sintering is continuously effected while relatively moving a current portion and a sintering subject; and a sintering device characterized in that the vertical position of the current electrodes is unchanged and the mold and the sintering subject are successively moved with respect to the current electrodes, so as to effect continuous sintering. A sintering method and a sintering device that are superior in sintering ability are provided wherein even if the sintered body is in the form of a long-size rod or has an uneven cross-section, the sintered body is uniform in quality.

Abstract translation: 在具有圆柱形成型空间的模具中对粉末进行直流加压烧结的方法，其中在相对移动当前部分和烧结对象的同时连续进行烧结; 以及烧结装置，其特征在于，电流电极的垂直位置不变，并且模具和烧结对象相对于电流电极连续移动，以实现连续烧结。 提供了烧结能力优异的烧结方法和烧结装置，其中即使烧结体呈长尺寸棒状或横截面不均匀，烧结体的质量均匀。

公开(公告)号：US5089401A

公开(公告)日：1992-02-18

申请号：US672388

申请日：1991-03-20

Applicant: Koki Fujita ,  Kozo Hara ,  Hitoshi Hashimoto ,  Sumio Kitahata

Inventor： Koki Fujita ,  Kozo Hara ,  Hitoshi Hashimoto ,  Sumio Kitahata

IPC: C12P19/14 ,  C07H3/06 ,  C12N9/10 ,  C12N9/26 ,  C12P19/12 ,  C12P19/18 ,  C12P19/24 ,  C12R1/06

CPC classification number: C12N9/2408 ,  C12P19/12 ,  C12P19/24 ,  Y10S435/83

Abstract: An enzymatic method for the preparation of a fructose-containing oligosaccharide, in which a .beta.-fructofuranosidase obtained by culturing Arthrobacter sp. K-1 (FERM BP-3192) as an enzyme is reacted on sucrose, raffinose or stachyose as the donor in the presence of an aldose or ketose as the receptor. The enzyme is characterized by:(1) activity on sucrose for the transglycosidation of a fructosyl group to the receptor in the presence of a monosaccharide, sugar alcohol, alkyl alcohol, glycoside or oligosaccharide;(2) activity for the decomposition of sucrose, elrose, neokestose, xylsucrose, raffinose and stachyose with inactivity on a saccharide selected from the group consisting of 1-kestose, nistose, inulobiose and levan biose;(3) optimum pH of 6.5 to 6.8 at 40.degree. C. with stability at a pH of 5.5 to 10;(4) optimum temperature of 55.degree. C. at a pH of 6.5 exhibiting at least 70% of residual activity at 60.degree. C.;(5) susceptibility to inhibition by the ions of silver, mercury, zinc, copper and tin;(6) two molecular weights of 52,000.+-.2,500 and 58,000.+-.2,500; and(7) two isoelectric points of pH 4.3 and pH 4.6.