公开(公告)号：US09198592B2

公开(公告)日：2015-12-01

申请号：US14546683

申请日：2014-11-18

Applicant: Kardium Inc.

Inventor： Daniel Martin Reinders ,  Daniel Robert Weinkam ,  Roxanne Wai Tak Louie ,  Danai Bisalputra

IPC: A61B18/00 ,  A61B18/12 ,  A61B5/042 ,  A61N1/372 ,  A61B5/00 ,  A61B5/053 ,  A61N1/362 ,  A61B5/01 ,  A61B18/14 ,  A61B19/00 ,  A61B17/00

CPC classification number: A61B5/6858 ,  A61B5/01 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/4836 ,  A61B5/6869 ,  A61B5/743 ,  A61B5/7435 ,  A61B18/06 ,  A61B18/082 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/24 ,  A61B34/20 ,  A61B2017/003 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/124 ,  A61B2018/1861 ,  A61B2034/107 ,  A61B2090/065 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/222 ,  A61N1/362 ,  A61N1/37247

Abstract: Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

公开(公告)号：US09192468B2

公开(公告)日：2015-11-24

申请号：US14162469

申请日：2014-01-23

Applicant: Kardium Inc.

Inventor： Samuel Victor Lichtenstein ,  Daniel Gelbart

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2451 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2250/006

Abstract: An artificial mitral valve is anchored in the left atrium by placing the valve between the annulus of the natural mitral valve and an artificial annulus. The artificial annulus is formed by inserting a tool into the coronary sinus, and adjusting the tool to force the wall of the left atrium to form an annulus above the artificial valve, this locking it in place and forming a hemostatic seal.

Abstract translation: 通过将瓣膜置于自然二尖瓣环和人造环之间，将人造二尖瓣固定在左心房中。 通过将工具插入冠状窦形成人造环，并且调整工具以迫使左心房的壁在人造瓣膜上方形成环形空间，将其锁定就位并形成止血密封。

公开(公告)号：US20150223802A1

公开(公告)日：2015-08-13

申请号：US14696853

申请日：2015-04-27

Applicant: Kardium Inc.

Inventor： Aleksandar TEGZES

IPC: A61B17/04

CPC classification number: A61B17/0401 ,  A61B17/0487 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0472 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61F2/2445 ,  A61F2/2466

Abstract: A device, kit and method may include or employ an implantable device (e.g., annuloplasty implant) and a plurality of tissue anchors. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve). Each of the tissue anchors may be guided into precise position by an intravascularly or percutaneously techniques. Constriction of the orifice may be accomplished via a variety of structures, for example an articulated annuloplasty ring, the ring attached to the tissue anchors. The annuloplasty ring may be delivered in an unanchored, generally elongated configuration, and implanted in an anchored generally arched, arcuate or annular configuration. Such may approximate the septal and lateral (clinically referred to as anterior and posterior) annulus of the mitral valve, to move the posterior leaflet anteriorly and the anterior leaflet posteriorly, thereby improving leaflet coaptation to reduce mitral regurgitation.

Abstract translation: 装置，试剂盒和方法可以包括或使用可植入装置（例如，瓣膜成形植入物）和多个组织锚固件。 可植入装置可定位在身体器官（例如，心脏）的空腔中并且可操作以收缩身体孔口（例如二尖瓣）。 每个组织锚可以通过血管内或经皮技术被引导到精确的位置。 孔的收缩可以通过各种结构来实现，例如铰接的瓣环成形术环，附接到组织锚的环。 瓣环成形术环可以以非锚定的，大致细长的构造递送，并且以一个固定的大体拱形，弓形或环形构型植入。 这可能近似于二尖瓣的间隔和外侧（临床上称为前后）环，以向后方移动后叶和前叶，从而改善小叶接合以减少二尖瓣反流。

公开(公告)号：US20150157400A1

公开(公告)日：2015-06-11

申请号：US14564463

申请日：2014-12-09

Applicant: Kardium Inc.

Inventor： Daniel Gelbart ,  Douglas Wayne Goertzen ,  Fernando Luis de Souza Lopes

IPC: A61B18/14 ,  A61B5/06

CPC classification number: A61B18/1492 ,  A61B5/06 ,  A61B5/065 ,  A61B5/4875 ,  A61B18/18 ,  A61B18/20 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/025

Abstract: A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

公开(公告)号：US09017320B2

公开(公告)日：2015-04-28

申请号：US13792781

申请日：2013-03-11

Applicant: Kardium Inc.

Inventor： Daniel Martin Reinders ,  Daniel Robert Weinkam ,  Roxanne Wai Tak Louie ,  Danai Bisalputra

IPC: A61B18/00 ,  A61B18/12 ,  A61B5/053 ,  A61B5/00 ,  A61B5/042 ,  A61B5/01 ,  A61B18/14 ,  A61N1/362

CPC classification number: A61B34/25 ,  A61B5/01 ,  A61B5/026 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6858 ,  A61B5/6869 ,  A61B5/743 ,  A61B5/7435 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/14 ,  A61B18/1492 ,  A61B2017/00199 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00708 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00904 ,  A61B2018/00988 ,  A61B2018/124 ,  A61B2034/254 ,  A61N1/362 ,  A61N1/37264 ,  G06F3/0482 ,  G06F3/04842

Abstract: Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

公开(公告)号：US08672998B2

公开(公告)日：2014-03-18

申请号：US13872870

申请日：2013-04-29

Applicant: Kardium Inc.

Inventor： Samuel Victor Lichtenstein ,  Daniel Gelbart

IPC: A61F2/24 ,  A61F11/00

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2451 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2250/006

Abstract: An artificial mitral valve is anchored in the left atrium by placing the valve between the annulus of the natural mitral valve and an artificial annulus. The artificial annulus is formed by inserting a tool into the coronary sinus, and adjusting the tool to force the wall of the left atrium to form an annulus above the artificial valve, this locking it in place and forming a hemostatic seal.

Abstract translation: 通过将瓣膜置于自然二尖瓣环和人造环之间，将人造二尖瓣固定在左心房中。 通过将工具插入冠状窦形成人造环，并且调整工具以迫使左心房的壁在人造瓣膜上方形成环形空间，将其锁定就位并形成止血密封。

公开(公告)号：US20130345797A1

公开(公告)日：2013-12-26

申请号：US13917469

申请日：2013-06-13

Applicant: Kardium Inc.

Inventor： Jonathan Dahlgren ,  Douglas Goertzen ,  Daniel Gelbart ,  Kelly Watkinson ,  Derrick To

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61B17/00234 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/00411 ,  A61B2017/00783 ,  A61B2017/00867 ,  A61B2017/0409 ,  A61B2017/0437 ,  A61B2017/0441 ,  A61B2017/045 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/22038 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2230/0091

Abstract: A device, kit and method may employ an implantable device (e.g., annuloplasty implant) and a tool to implant such. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve). Tissue anchors are guided into precise position by an intravascularly deployed anchor guide frame and embedded in an annulus. Constriction of the orifice may be accomplished via a variety of structures, for example by cinching a flexible cable or anchored annuloplasty ring, the cable or ring attached to the tissue anchors. The annuloplasty ring may be delivered in a generally elongated configuration, and implanted in an anchored generally arch, arcuate or annular configuration. Such may move a posterior leaflet anteriorly and an anterior leaflet posteriorly, improving leaflet coaptation to eliminate mitral regurgitation.

Abstract translation: 装置，套件和方法可以使用可植入装置（例如，瓣环成形植入物）和植入其的工具。 可植入装置可定位在身体器官（例如心脏）的空腔中并可操作以收缩身体孔口（例如二尖瓣）。 组织锚通过血管内展开的锚导引框架被引导到精确的位置，并嵌入环形空间。 孔的收缩可以通过各种结构实现，例如通过将柔性电缆或锚定瓣环成形术环固定，附接到组织锚的电缆或环。 瓣膜成形术环可以以大致细长的构造递送，并且以锚定的大致拱形，弓形或环形构型植入。 这样可以向后移动后部小叶和前叶，改善小叶接合以消除二尖瓣反流。

公开(公告)号：US20130304065A1

公开(公告)日：2013-11-14

申请号：US13942354

申请日：2013-07-15

Applicant: KARDIUM INC.

Inventor： Fernando Luis de Souza LOPES ,  Saar MOISA ,  Jorge JARAMILLO ,  Douglas Wayne GOERTZEN ,  Peter Josiah HAWES ,  Ashkan SARDARI ,  Aldo Antonio SALVESTRO

IPC: A61B18/14

CPC classification number: A61B18/00 ,  A61B5/026 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/065 ,  A61B5/6843 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2090/065 ,  A61M25/0074 ,  A61M25/0082

Abstract: Systems, methods, and devices allow intravascular or percutaneous mapping, orientation or ablation, or combinations thereof in bodily cavities or lumens. A device includes a plurality of elongate members which are moveable between an unexpanded configuration, a bent or coiled stack configuration and an expanded or fanned configuration. The elongate members form a stack arrangement in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducers carried by elongate members may sense various physiological characteristics of or proximate tissue, for instance temperature, and/or may apply energy to or proximate tissue, for example to perform ablation. The device is retractable.

Abstract translation: 系统，方法和装置允许在体腔或腔内进行血管内或经皮贴图，取向或消融或其组合。 一种装置包括多个细长构件，其可在未膨胀构型，弯曲或盘绕堆叠构型和膨胀或扇形构型之间移动。 细长构件形成未展开构型的堆叠布置以配合穿过导管护套。 细长构件遵循相应的弓形或曲线路径，从护套延伸到弯曲或卷绕的堆叠构型中，采用蜗壳，滚动或菱形，并且可以嵌套。 细长构件相对于彼此圆周地被扇形或径向间隔开成扩展或扇形构型。 由细长构件携带的传感器可以感测组织的各种生理特征，例如温度，和/或可以将能量施加到或靠近组织，例如进行消融。 设备可缩回。

公开(公告)号：US20130197513A1

公开(公告)日：2013-08-01

申请号：US13793076

申请日：2013-03-11

Applicant: Kardium Inc.

Inventor： Fernando Luis de Souza Lopes ,  Saar Moisa ,  Peter Josiah Hawes

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B5/04 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/6858 ,  A61B5/6885 ,  A61B18/14 ,  A61B2018/0016 ,  A61B2018/00208 ,  A61B2018/00267 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/1407 ,  A61B2018/1417 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2562/0209 ,  A61B2562/0271 ,  A61B2562/04 ,  A61B2562/046 ,  A61N1/056

Abstract: A medical device system is disclosed including a high-density arrangement of transducers, which may be configured to ablate, stimulate, or sense characteristics of tissue inside a bodily cavity, such as an intra-cardiac cavity. High-density arrangements of transducers may be achieved, at least in part, by overlapping elongate members on which the transducers are located, and varying sizes, shapes, or both of the transducers, especially in view of the overlapping of the elongate members. Also, the high-density arrangements of transducers may be achieved, at least in part, by including one or more recessed portions in an elongate member in order to expose one or more transducers on an underlying elongate member in a region adjacent an elongate-member-overlap region.

公开(公告)号：US20130041405A1

公开(公告)日：2013-02-14

申请号：US13652299

申请日：2012-10-15

Applicant: KARDIUM INC.

Inventor： Daniel Gelbart ,  Samuel Victor Lichtenstein

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00584 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/00623 ,  A61B2017/00637 ,  A61B2017/00862 ,  A61B2017/22061

Abstract: A device for closing holes in tissue is delivered via a catheter to the inside of a body lumen such as a heart. An elastic barbed clip is expanded, pulled into the tissue and released, pulling the tissue with it. The operation is fully reversible.

Abstract translation: 用于封闭组织中的孔的装置通过导管输送到诸如心脏的体腔内部。 弹性带刺的夹子被膨胀，拉入组织并释放，用它拉动组织。 操作完全可逆。