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    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    44.
    发明授权
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US07098331B2

    公开(公告)日：2006-08-29

    申请号：US10379868

    申请日：2003-03-05

    Applicant: Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    Inventor： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC: C07D405/12 ,  C07D239/26

    CPC classification number: A61K31/506 ,  C07D405/14

    Abstract: Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    Abstract translation: 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    N-phenylglycinamide CCK antagonists and pharmaceutical compositions containing them
    48.
    发明授权
    N-phenylglycinamide CCK antagonists and pharmaceutical compositions containing them 失效
    N-苯基甘氨酰胺CCK拮抗剂和含有它们的药物组合物

    公开(公告)号：US5475106A

    公开(公告)日：1995-12-12

    申请号：US924065

    申请日：1992-10-08

    Applicant: Jean-Dominique Bourzat ,  Marc Capet ,  Claude Cotrel ,  Claude Guyon ,  Franco Manfre ,  Gerard Roussel

    Inventor： Jean-Dominique Bourzat ,  Marc Capet ,  Claude Cotrel ,  Claude Guyon ,  Franco Manfre ,  Gerard Roussel

    IPC: A61K38/00 ,  A61K38/05 ,  A61P1/00 ,  A61P3/04 ,  A61P21/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P35/00 ,  C07K1/02 ,  C07K1/113 ,  C07K5/00 ,  C07K5/06 ,  C07K5/065 ,  A61K31/325 ,  C07C205/00 ,  C07C229/00

    CPC classification number: C07K5/06026 ,  A61K38/00

    Abstract: Compounds of formula: ##STR1## in which R.sub.1 represents a hydrogen atom, an alkyl or alkoxycarbonyl radical or a phenyl radical, optionally substituted,R.sub.2 represents an alkoxy, optionally substituted cycloalkyloxy, cycloalkylalkyloxy, phenylalkyloxy, polyfluoroalkyloxy or cinnamyloxy radical or a radical --NR.sub.5 R.sub.6,R.sub.3 represents a phenylamino radical in which the phenyl ring is optionally substituted, an optionally substituted phenyl radical or a naphthyl, indolyl or quinolyl radical,R.sub.4 represents a substituted phenyl radical,R.sub.5 and R.sub.6, which may be identical or different, represent a hydrogen atom or an alkyl, optionally substituted phenyl, indanyl, cycloalkylalkyl, cycloalkyl or phenylalkyl radical, or alternatively R.sub.5 and R.sub.6, together with the nitrogen atom to which they are attached, form a heterocycle, their preparation and medicinal products containing them.

    Abstract translation: PCT No.PCT / FR91 / 00174 Sec。 371日期：1992年10月8日 102（e）日期1992年10月8日PCT 1991年3月5日PCT公布。 第WO91 / 13907号公报 1991年9月19日，化学式：其中R 1表示氢原子，烷基或烷氧基羰基或苯基，任意取代的式（I）化合物：R 2表示烷氧基，任选取代的环烷氧基，环烷基烷氧基，苯基烷氧基 ，多氟烷氧基或肉桂氧基或自由基-NR5R6，R3表示苯基氨基，其中苯环任选被取代，任选取代的苯基或萘基，吲哚基或喹啉基，R4表示取代的苯基，R5和R6， 其可以相同或不同，表示氢原子或烷基，任选取代的苯基，二氢化茚基，环烷基烷基，环烷基或苯基烷基，或者R5和R6与它们所连接的氮原子一起形成杂环，它们 制剂和含有它们的药用产品。

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