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公开(公告)号：US20070212341A1
公开(公告)日：2007-09-13
申请号：US11658152
申请日：2005-07-28
Applicant: Mathias Schmidt , Thomas Beckers
Inventor： Mathias Schmidt , Thomas Beckers
CPC classification number: C12N15/86 , C12N9/12 , C12N2710/14143
Abstract: The invention relates to a method for preparing active kinases which, in native form, contain a pH domain.
Abstract translation: 本发明涉及一种制备以天然形式含有pH结构域的活性激酶的方法。
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公开(公告)号：US08637165B2
公开(公告)日：2014-01-28
申请号：US13250920
申请日：2011-09-30
Applicant: Edward Siahaan , John B. Ardisana, II , Mathias Schmidt , Jason Sloey , Albert J. Golko , Eric Jol
Inventor： Edward Siahaan , John B. Ardisana, II , Mathias Schmidt , Jason Sloey , Albert J. Golko , Eric Jol
IPC: H01R13/03
CPC classification number: H01R13/03
Abstract: A corrosion-resistant electrical connector is disclosed. A multi-layer nickel underplating is applied to the substrate material of the connector contacts. The three layers of nickel include a leveling nickel layer, a sulfumate nickel layer, and a high-phosphorous nickel layer. A layer of gold is applied to the nickel underplating in an embodiment.
Abstract translation: 公开了一种耐腐蚀电连接器。 将多层镍底板施加到连接器触头的基板材料上。 三层镍包括平整镍层，亚磺酸镍层和高磷镍层。 在一个实施例中，将一层金应用于镍底层。
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公开(公告)号：US20130084760A1
公开(公告)日：2013-04-04
申请号：US13250920
申请日：2011-09-30
Applicant: Edward Siahaan , John B. Ardisana, II , Mathias Schmidt , Jason Sloey , Albert J. Golko , Eric Jol
Inventor： Edward Siahaan , John B. Ardisana, II , Mathias Schmidt , Jason Sloey , Albert J. Golko , Eric Jol
IPC: H01R13/03
CPC classification number: H01R13/03
Abstract: A corrosion-resistant electrical connector is disclosed. A multi-layer nickel underplating is applied to the substrate material of the connector contacts. The three layers of nickel include a leveling nickel layer, a sulfumate nickel layer, and a high-phosphorous nickel layer. A layer of gold is applied to the nickel underplating in an embodiment.
Abstract translation: 公开了一种耐腐蚀电连接器。 将多层镍底板施加到连接器触头的基板材料上。 三层镍包括平整镍层，亚磺酸镍层和高磷镍层。 在一个实施例中，将一层金应用于镍底层。
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公开(公告)号：US08273890B2
公开(公告)日：2012-09-25
申请号：US12667093
申请日：2008-06-26
Applicant: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
Inventor： Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
IPC: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/44
CPC classification number: C07D471/04
Abstract: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
Abstract translation: 本发明涉及式（I）的噻吩 - 咪唑并吡啶化合物，其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
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公开(公告)号：US07723523B2
公开(公告)日：2010-05-25
申请号：US11597142
申请日：2005-05-25
Applicant: Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
Inventor： Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
IPC: C07D471/02
CPC classification number: C07D495/04
Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.
Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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Patent Agency Ranking
46.发明授权Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer 失效用于治疗增殖性疾病如癌症的四氢吡啶并噻吩公开(公告)号：US07714135B2
公开(公告)日：2010-05-11
申请号：US11883596
申请日：2006-02-08
Applicant: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Björn Bartels
Inventor： Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Björn Bartels
IPC: C07D471/02
CPC classification number: C07D495/04
Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号：US07714134B2
公开(公告)日：2010-05-11
申请号：US11628369
申请日：2005-06-10
Applicant: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
Inventor： Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC: C07D471/02
CPC classification number: C07D495/04 , A61K31/4365
Abstract: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.
Abstract translation: 其中Ra和Rb具有本说明书中指出的含义的某种式（1）的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式（I）化合物，其中Ra和Rb具有说明书中所示的含义。
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公开(公告)号：US20090258873A1
公开(公告)日：2009-10-15
申请号：US12412021
申请日：2009-03-26
Applicant: Klaus PEKARI , Mathias SCHMIDT , Thomas BAR , Thomas BECKERS , Petra GIMMNICH
Inventor： Klaus PEKARI , Mathias SCHMIDT , Thomas BAR , Thomas BECKERS , Petra GIMMNICH
IPC: A61K31/4365 , A61K31/5375 , A61K31/496 , A61P35/04 , A61P35/02
CPC classification number: C07D495/04
Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号：US07544066B1
公开(公告)日：2009-06-09
申请号：US12135013
申请日：2008-06-06
Applicant: Stephen Brian Lynch , Jason Sloey , Cameron Frazier , Mathias Schmidt
Inventor： Stephen Brian Lynch , Jason Sloey , Cameron Frazier , Mathias Schmidt
IPC: H01R12/00
CPC classification number: H01R12/592 , H01R12/721
Abstract: An electrical connector that utilizes a flexible substrate for providing electrical contact surfaces within the electrical connector is disclosed. Advantageously, the electrical contact surfaces can be precisely formed on the flexible substrate such that manual assembly of individual contacts (e.g., pins) for a connector can be avoided. In one embodiment, the flexible substrate also facilitates connection of the electrical connector to other electrical components, such as other substrates, integrated circuits, etc., without having to solder leads or pins of a connector to a printed circuit board. In one implementation, the flexible substrate can be integrally formed with a system substrate.
Abstract translation: 公开了一种电连接器，其利用柔性基板在电连接器内提供电接触表面。 有利地，可以在柔性基板上精确地形成电接触表面，从而可以避免用于连接器的单独触头（例如，引脚）的手动组装。 在一个实施例中，柔性基板还便于将电连接器连接到诸如其它基板，集成电路等的其它电气部件，而不必将连接器的引线或引脚焊接到印刷电路板。 在一个实施方案中，柔性基底可以与系统基底一体地形成。
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50.发明申请Tetrahydropyridothiophenes as Antiproliferative Agents for the Treatment of Cancer 失效四氢吡啶并噻吩作为治疗癌症的抗增生剂公开(公告)号：US20090098133A1
公开(公告)日：2009-04-16
申请号：US11883624
申请日：2006-02-10
Applicant: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
Inventor： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
IPC: C07D495/04 , A61K31/44 , A61K31/4365 , A61K31/5377 , A61K39/395 , A61P35/00
CPC classification number: C07D495/04
Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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