公开(公告)号：US20200320754A1

公开(公告)日：2020-10-08

申请号：US16375152

申请日：2019-04-04

Applicant: Optos Plc

Inventor： Praveen Ashock ,  Daniel Hurst ,  Alan Anderson

IPC: G06T11/00 ,  G06T5/00 ,  G06T3/40

Abstract: A method of generating a look-up table, LUT, for constructing a dewarped B-scan image from A-scans of a cropped part of a sequence of acquired OCT A-scans, the LUT associating each of a plurality of pixel arrays that are to form the dewarped B-scan image with a respective A-scan in the cropped part. The method comprises: using an indication of a spatial distribution of scan locations of A-scans to determine a dewarp function for selecting, from among acquired A-scans, A-scans having uniformly spaced scan locations; using the function and cropping information, in accordance with which the cropped part is cropped from the acquired sequence, to select, for each array, a respective A-scan from the sequence such that A-scans are selected from the cropped part and have uniformly spaced scan locations; and storing, for each array, a respective pixel array identifier in association with a respective identifier of the selected A-scan.

公开(公告)号：US20200237209A1

公开(公告)日：2020-07-30

申请号：US16637052

申请日：2017-08-14

Applicant: Optos PLC

Inventor： David Clifton

IPC: A61B3/00 ,  A61B3/10 ,  G06T7/246 ,  A61B3/12

Abstract: A method of processing a sequence of images of a retina acquired by an ophthalmic device to generate retinal position tracking information indicative of retina movement during acquisition. The method includes (i) receiving one or more images of the retina; (ii) calculating a cross-correlation between a reference image and an image based on the received image(s) to acquire an offset between the image and reference image; and repeating processes (i) and (ii) to acquire, as the tracking information, respective offsets for images that are based on the respective received image(s). Another step includes modifying the reference image during the repeating, by determining a measure of similarity between correspondingly located regions of pixels in two or more received images and accentuating features in the reference image representing structures of the imaged retina in relation to other features in the reference image based on the determined measure of similarity.

公开(公告)号：US10292582B2

公开(公告)日：2019-05-21

申请号：US15509844

申请日：2015-08-25

Applicant: OPTOS PLC

Inventor： Gonzalo Muyo ,  Derek Swan

IPC: A61B3/10 ,  A61B3/135

Abstract: An ophthalmoscope (10) comprising a light source (12), a first scanner (14), a first scan transfer element (16), a second scanner (18), and a second scan transfer element (20), which provide a two-dimensional scan of incident light from an apparent point source at a pupillary point of an eye (22) onto the fundus of the eye, and which descan a two-dimensional scan of return light from the fundus of the eye to provide return light from an apparent point source at the first scanner, wherein the first scan transfer element comprises a free-form element which has a shape defined to provide aberration correction of the return light from the fundus of the eye.

公开(公告)号：US20180199811A1

公开(公告)日：2018-07-19

申请号：US15924106

申请日：2018-03-16

Applicant: Optos PLC

Inventor： Christopher David Creasey ,  Stuart Brian Milne ,  Andrew Fogg

IPC: A61B3/12 ,  G02B26/10 ,  G02B26/08 ,  A61N5/06 ,  A61B3/00 ,  A61F9/008 ,  A61B3/14 ,  A61B3/10

CPC classification number: A61B3/12 ,  A61B3/0008 ,  A61B3/1025 ,  A61B3/14 ,  A61F9/008 ,  A61F2009/00897 ,  A61N5/06 ,  G02B26/0833 ,  G02B26/101

Abstract: Apparatus for illuminating the retina of an eye. The apparatus includes an illumination device and a lens system. The illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system. The apparatus also includes an illumination transfer device. The illumination transfer device has two foci and the apparent point source of the lens system is provided at a first focus point of the illumination transfer device and an eye is accommodated at a second focus point of the illumination transfer device. The illumination transfer device transfers the incident illumination from the apparent point source into the eye to illuminate the retina.

公开(公告)号：US09978140B2

公开(公告)日：2018-05-22

申请号：US15139179

申请日：2016-04-26

Applicant: Optos PLC

Inventor： Alan Duncan Fleming

IPC: G06K9/00 ,  G06T7/00 ,  A61B3/00 ,  A61B3/12 ,  G06T7/73

CPC classification number: G06T7/0012 ,  A61B3/0025 ,  A61B3/12 ,  G06T7/004 ,  G06T7/0081 ,  G06T7/11 ,  G06T7/70 ,  G06T7/73 ,  G06T2207/20061 ,  G06T2207/30041 ,  G06T2207/30101

Abstract: The present disclosure relates to a computer-readable storage medium storing instructions that can cause a processor to process image data defining an image of a vascular structure of temporal vascular arcades of a retina to estimate a location of the fovea of the retina in the image by transforming received image data such that the vascular structure in the image defined by the transformed image data is more circular than the vascular structure defined by the image data; calculating, for each of a plurality of pixels of the transformed image data, a respective local orientation vector indicative of the orientation of any blood vessel present in the image; calculating a normalized local orientation vector for each of the pixels; operating on an array of accumulators; and estimating the location of the fovea in the image of the retina using the location of a pixel of the transformed image data.

公开(公告)号：US09390499B2

公开(公告)日：2016-07-12

申请号：US14404162

申请日：2013-05-28

Applicant: Optos PLC

Inventor： David Clifton

IPC: G06K9/00 ,  G06T7/00 ,  G06T7/40 ,  A61B3/12 ,  G06K9/46 ,  G06T3/00 ,  A61B1/04 ,  A61B5/00

CPC classification number: G06T7/0014 ,  A61B3/1225 ,  G06K9/0061 ,  G06K9/4628 ,  G06K2009/00932 ,  G06T3/0068 ,  G06T3/0093 ,  G06T7/0016 ,  G06T7/42 ,  G06T2207/10004 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/20016 ,  G06T2207/20032 ,  G06T2207/20036 ,  G06T2207/20064 ,  G06T2207/30041 ,  G06T2207/30201

Abstract: A laser scanning ophthalmoscope obtains images of a retina. An image is processed by (i) mapping an image along a one dimensional slice; (ii) computing a wavelet scalogram of the slice; (iii) mapping ridge features from the wavelet scalogram; repeating steps (i), (ii) and (iii) for one or more mapped image slices. The mapped ridge features from the slices are superimposed. Textural information is derived from the superimposed mapped ridge features. The analysis can be tuned to detect various textural features, for example to detect image artifacts, or for retinal pathology classification.

Abstract translation: 激光扫描检眼镜获得视网膜的图像。 通过（i）沿着一维切片映射图像来处理图像; （ii）计算切片的小波缩放图; （iii）从小波图示中绘制脊特征; 对于一个或多个映射的图像切片重复步骤（i），（ii）和（iii）。 来自切片的映射脊特征被叠加。 纹理信息是从叠加的映射脊特征导出的。 可以调整分析以检测各种纹理特征，例如检测图像伪像，或用于视网膜病理学分类。

公开(公告)号：US20150216408A1

公开(公告)日：2015-08-06

申请号：US14422671

申请日：2013-10-01

Applicant: Optos PLC

Inventor： William Brown ,  Mike Williams ,  Anthony Corcoran ,  Derek Swan

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/1015 ,  A61B3/1025 ,  A61B3/1225 ,  A61B3/14

Abstract: A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source (12) of collimated light, a scanning device (14, 16, 1328, 1319), a scan transfer device (20) and a detector (1310). The scan transfer device has a first focus (16) at which an apparent point source is provided and a second focus (24) at which an eye (524, 1324) may be accommodated. The scan transfer device transfers a two-dimensional collimated light scan from the apparent point source into the eye. An optical coherence tomography (OCT) system (900) is combined with the SLO, the OCT system providing OCT reference and sample beams. The OCT sample beam (902) propagates along the same optical path as of the SLO collimated light through the scan transfer device. An aberration compensator (1204, 1316) automatically compensates for systematic aberrations and/or changes in wavefront introduced by scanning elements and the scan transfer device as a function of scan angle.

Abstract translation: 用于对眼睛的视网膜进行成像的扫描激光检眼镜（SLO）包括准直光源（12），扫描装置（14,16,1328,1319），扫描传送装置（20）和检测器（1310） 。 扫描传送装置具有第一焦点（16），在该第一焦点处提供视点信号源，第二焦点（24）可以容纳眼睛（524,1324）。 扫描传送装置将来自视点的二维准直光扫描转移到眼睛中。 光学相干断层扫描（OCT）系统（900）与SLO组合，OCT系统提供OCT参考和采样光束。 OCT采样光束（902）沿着与通过扫描传送装置的SLO准直光相同的光路传播。 像差补偿器（1204,1316）自动补偿由扫描元件和扫描传送装置引起的波前的系统像差和/或变化作为扫描角度的函数。

公开(公告)号：US20250090017A1

公开(公告)日：2025-03-20

申请号：US18885166

申请日：2024-09-13

Applicant: Optos plc

Inventor： Derek Swan

IPC: A61B3/10 ,  G16H10/60

Abstract: A multi-modal ophthalmic imaging system for acquiring ophthalmic images of a patient's eye comprising: a first imaging module, operable in a first imaging modality, for acquiring a first ophthalmic image of a first portion of the patient's eye and one or more further imaging modules, each operable in a different imaging modality. The imaging system further comprises a control module arranged to: detect an anomaly in the first ophthalmic image that is indicative of an ocular disease, determine a region of interest in the patient's eye based on the detected anomaly wherein the region of interest is a region within the patient's eye that is predicted to contain a second anomaly and determine, based on the second anomaly, a second imaging modality for imaging the determined region of interest and control the selected second imaging module to acquire a second ophthalmic image of the determined region of interest.

公开(公告)号：US12226159B2

公开(公告)日：2025-02-18

申请号：US17492592

申请日：2021-10-02

Applicant: OPTOS PLC

Inventor： Praveen Ashok ,  Alan Anderson

IPC: A61B3/10 ,  A61B5/00 ,  G16H30/40

Abstract: A method of processing B-scans acquired by an OCT imaging system to generate correction data for compensating for axial displacements between B-scans caused by a variation in distance between the OCT imaging system and an imaging target, and to generate a reliability indicator indicative of a reliability of the correction data. The correction data is generated by determining, for each pair of adjacent B-scans, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans. The reliability indicator is generated by: calculating values indicative of speeds or accelerations of the imaging target relative to the OCT imaging system when pairs of B-scans were acquired; where at least a predetermined number of calculated values exceed a threshold, setting the reliability indictor to indicate that the correction data is unreliable, and otherwise to indicate that the correction data is reliable.

公开(公告)号：US20250045917A1

公开(公告)日：2025-02-06

申请号：US18792928

申请日：2024-08-02

Applicant: Optos plc

Inventor： Alan Anderson ,  Gonzalo Muyo ,  Miguel Preciado ,  Bavishna Balagopal

IPC: G06T7/00 ,  G06T7/10

Abstract: A system arranged to process an anterior-segment optical coherence tomography, AS-OCT, image comprising representations of portions of a scleral spur of an eye to obtain a geometric measurement of the eye, comprising data processing hardware arranged to: process the AS-OCT image to acquire respective locations in the AS-OCT image of the representations of the portions of the scleral spur of the eye in the AS-OCT image; and obtain the geometric measurement based on the acquired locations. The system further comprises an OCT imaging system which is operable to acquire the AS-OCT image and comprises a fixation target to fix a gaze direction of the eye during acquisition of the AS-OCT image such that an axis in the AS-OCT image corresponding to a pupillary axis of the eye is aligned with a direction in the AS-OCT image corresponding to an axial imaging direction of the OCT imaging system.