公开(公告)号：US20170057852A1

公开(公告)日：2017-03-02

申请号：US15118832

申请日：2015-02-13

Applicant: Stellenbosch University

Inventor： Thomas Eugene CLOETE ,  Danielle Marguerite DU PLESSIS ,  Marelize BOTES

IPC: C02F3/04 ,  C02F1/38 ,  C02F3/30 ,  C02F3/00 ,  C02F3/10

CPC classification number: C02F3/043 ,  C02F1/385 ,  C02F3/006 ,  C02F3/04 ,  C02F3/101 ,  C02F3/105 ,  C02F3/108 ,  C02F3/109 ,  C02F3/302 ,  C02F3/303 ,  C02F2101/101 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2101/166 ,  C02F2103/023 ,  C02F2103/325 ,  C02F2209/001 ,  C02F2209/005 ,  C02F2209/42 ,  C02F2209/44 ,  C02F2303/20 ,  Y02W10/15

Abstract: A biofiltration system for filtering wastewater includes a tower containing a packed bed on which biofilm is able to form and an air inlet below the packed bed and an air outlet above the packed bed. A water feed above the packed bed disperses wastewater over the packed bed. The biofilm serves as a biological contact reactor removing organic and/or inorganic contaminants from the water. Following filtration of the water through the packed bed, filtered water and solid waste sloughed off from the packed bed collects in a sump below the packed bed. Water flows from a water outlet in the sump to a centrifugal separator that separates solid material from water drawn from the sump to expel a waste stream and a filtered water stream.

Abstract translation: 用于过滤废水的生物过滤系统包括含有生物膜能够形成的填充床和填充床下方的空气入口的塔架以及填充床上方的空气出口。 填充床上方的进水将废水分散在填充床上。 生物膜用作从水中去除有机和/或无机污染物的生物接触反应器。 在通过填充床过滤水后，过滤的水和从填充床脱落的固体废物收集在填充床下面的集油槽中。 水从贮槽中的出水口流到离心分离器，其将固体材料与从贮槽抽出的水分离，排出废物流和过滤的水流。

公开(公告)号：US20160298804A1

公开(公告)日：2016-10-13

申请号：US15093022

申请日：2016-04-07

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Willem Adolph Landman ,  James Nicholas Larmuth

IPC: F16M11/24 ,  F24J2/52

CPC classification number: F16M11/24 ,  F16B7/0493 ,  F16B7/18 ,  F24S25/00 ,  F24S25/12 ,  F24S25/13 ,  F24S25/16 ,  F24S25/30 ,  F24S25/65 ,  F24S25/67 ,  F24S25/70 ,  F24S2025/80 ,  H02S20/30 ,  Y02E10/47

Abstract: A height adjustable pylon and supporting frame assembly is provided. The frame includes two frame members meeting at a corner with the frame members being generally co-planar and the pylon being urged into the corner so as to extend at generally right angles to a plane including the two frame members. A fastener assembly has two end portions each anchored relative its associated frame member so as to extend transversely to it. The fastener assembly includes an intermediate saddle portion engaging a surface of the pylon that is directed outwardly relative to the corner with the pylon being urged into the corner when the fastener assembly is tightened to engage the pylon and lock it axially relative to the frame members in a selected position. Preferably, the frame members each form two upper and two lower frame members of two trusses. Lower ends of the pylons may support the assembly.

Abstract translation: 提供高度可调的塔架和支撑框架组件。 该框架包括两个框架构件，该框架构件在一角处会合，框架构件通常是共面的，并且该托架被推入角落中，以便与包括两个框架构件的平面大致成直角地延伸。 紧固件组件具有两个端部，每个端部相对于其相关联的框架构件锚定，以便横向延伸。 所述紧固件组件包括中间鞍座部分，所述中间鞍形部分接合所述塔的表面，所述中间鞍形部分相对于所述角部向外指向，当所述紧固件组件被紧固以接合所述塔架并且相对于所述框架构件轴向地锁定时， 所选位置 优选地，框架构件形成两个桁架的两个上部和两个下部框架构件。 塔的下端可以支撑组件。

公开(公告)号：US20160298354A1

公开(公告)日：2016-10-13

申请号：US15092997

申请日：2016-04-07

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Paul Gauché

IPC: E04H12/20 ,  F16M11/24 ,  F24J2/52 ,  E04H12/22

CPC classification number: E04H12/20 ,  E04H12/2238 ,  E04H12/2292 ,  E04H2012/006 ,  F03D13/20 ,  F16M11/24 ,  F24S25/12 ,  F24S25/13 ,  F24S25/16 ,  F24S25/30 ,  F24S25/70 ,  H02S30/10 ,  Y02E10/47

Abstract: A supporting frame includes a truss composed of an upper straight frame member and a parallel lower straight frame member supported at their ends in spaced relationship relative to each other. At least two spans of divergent inclined brace member extend between them with the ends of the brace member spans each being securable to the upper or lower straight frame member by means of a fastener. Limited relative longitudinal movement of the upper and lower straight frame members is permitted before a fastener is secured to fix the positions at which the ends of the brace member spans are attached to the upper and lower straight frame members. In one application two trusses meet at a corner with a pylon being urged in the plane of the supporting frame into a corner between two frame members of each pair of trusses to extend at right angles to the frame.

Abstract translation: 支撑框架包括由上部直框架构件和平行的下直立框架构件构成的桁架，所述平行下部直框架构件在其端部以彼此间隔开的关系支撑。 至少两个发散的倾斜支撑构件的跨度在它们之间延伸，并且支撑构件的端部跨越每个通过紧固件固定到上部或下部直框架构件。 在紧固件固定之前允许上下直框架构件的有限的相对纵向运动将固定支架构件的端部的位置固定在上下直框构件上。 在一个应用中，两个桁架在角落处相遇，其中支柱被支撑在平面内的塔被推入到每对桁架的两个框架构件之间的角部中以与框架成直角延伸。

公开(公告)号：US09457321B2

公开(公告)日：2016-10-04

申请号：US14415406

申请日：2013-07-19

Applicant: Stellenbosch University

Inventor： Lubertus Klumperman ,  Osama Esmail Bshena ,  Thomas Eugene Cloete ,  Nonjabulo Prudence Gule

IPC: C08F212/08 ,  C08F222/40 ,  C08F8/00 ,  C08F8/14 ,  B01D65/08 ,  B01D71/38 ,  B01D71/62 ,  B01D71/80

CPC classification number: B01D65/08 ,  B01D71/38 ,  B01D71/62 ,  B01D71/80 ,  B01D2321/168 ,  C08F8/00 ,  C08F8/14 ,  C08F212/08 ,  C08F2222/404 ,  C08F222/08

Abstract: A polymer compound (I) with bacteria-adhesion inhibition properties against bacteria such as P. aeruginosa Xen 5, E. coli Xen 14, S. typhimurium Xen 26, S. aureus Xen 36 and K. pneumoniae Xen 39 is described. The group R is provided by a substituted furanone linked by an alkyl chain or, more preferably a hydrophilic moiety such as oligo(ethylene oxide) ((CH2—CH2—O)i) to the polymer backbone. The group R may be the same or different along the polymer backbone. The invention also provides nanofibers and coatings which include a polymer compound as defined above.

公开(公告)号：US20160068850A1

公开(公告)日：2016-03-10

申请号：US14936840

申请日：2015-11-10

Applicant: Lallemand Hungary Liquidity Management LLC ,  Stellenbosch University

Inventor： Elena Brevnova ,  John E. McBride ,  Erin Wiswall ,  Kevin S. Wenger ,  Nicky Caiazza ,  Heidi Lau ,  Aaron Argyros ,  Frank Agbogbo ,  Charles F. Rice ,  Trisha Barrett ,  John S. Bardsley ,  Abigail Foster ,  Anne K. Warner ,  Mark Mellon ,  Ryan Skinner ,  Indraneel Shikhare ,  Riaan Den Haan ,  Chhayal V. Gandhi ,  Alan Belcher ,  Vineet B. Rajgarhia ,  Allan C. Froehlich ,  Kristen M. Deleault ,  Emily Stonehouse ,  Shital A. Tripathi ,  Jennifer Gosselin ,  Yin-Ying Chiu ,  Haowen Xu

IPC: C12N15/81 ,  C12N9/24 ,  C12N15/52 ,  C12N9/42

CPC classification number: C12N15/52 ,  C12N9/2405 ,  C12N9/2437 ,  C12N9/2445 ,  C12N9/248 ,  C12N9/2482 ,  C12N15/81 ,  C12P7/06 ,  C12Y302/01004 ,  C12Y302/01008 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/17

Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Abstract translation: 本发明涉及分泌全套或全套的酶的酵母菌株或菌株，以水解玉米淀粉，玉米纤维，木质纤维素（包括水解纤维素中的连接酶，半纤维素和 木质素和碳水化合物之间）并利用戊糖（木糖和阿拉伯糖）。 本发明还涉及在酵母中对于各种酶活性良好表达的蛋白质组。 所得的菌株或菌株可以同时水解淀粉和纤维素。 所产生的菌株或菌株也可以代谢工程化以产生较少的甘油和吸收乙酸盐。 所得的菌株或菌株也可用于从颗粒淀粉生产乙醇而不液化。 所得到的菌株或菌株可以进一步用于减少在同时糖化和发酵（SSF）过程中水解生物质原料所需的外部酶的量，或者在当前蔗糖分解酶负载下在SSF期间提高乙醇的产率。 此外，本发明的多种酶可以在本发明的细胞中共表达以提供对生物质原料的协同消化作用。 在一些方面，表达不同异源糖分解酶的宿主细胞也可以共同共培养并用于从生物质原料生产乙醇。

公开(公告)号：US20160010876A1

公开(公告)日：2016-01-14

申请号：US14797662

申请日：2015-07-13

Applicant: Stellenbosch University

Inventor： Hanno Carl Rudolf Reuter ,  Johann Pierre Terblanche ,  Detlev Gustav Kröger

IPC: F24D11/00 ,  F24D19/10

CPC classification number: F24D11/007 ,  F24D19/109 ,  F24D2200/14 ,  F24D2220/0271 ,  Y02B10/20 ,  Y02B10/70

Abstract: An air temperature regulating assembly is provided having a packed rock bed through which air may flow between outer and inner spaces by way of interstices between rock units in order to transfer heat to or from the rock bed, in use. Dampers control the flow of air between the outer space, the inner space, an enclosed air space the temperature of which is to be regulated by raising or lowering it and the surrounding atmosphere. A fan moves air within the assembly. The rock bed is in the form of a pile of rocks having an upper surface that is inclined and directed in the general direction of the sun to directly absorb solar energy. The outer space is defined between the upper inclined surface of the rock bed and a transparent cover spaced upwardly from the surface of the rock bed.

Abstract translation: 提供了具有填充岩床的空气温度调节组件，空气可以通过空间在外部空间和内部空间之间通过岩石单元之间的间隙流动，以在使用中将热量传递到岩石床或从岩石床传递热量。 阻尼器控制外部空间，内部空间之间的空气流动，其温度通过升高或降低温度以及周围环境而被调节的封闭空气空间。 风扇在组件内移动空气。 岩床是一堆岩石的形式，其上表面倾斜并朝向太阳的大致方向直接吸收太阳能。 外部空间限定在岩石床的上倾斜表面和从岩石床的表面向上间隔开的透明盖之间。

公开(公告)号：US20150292773A1

公开(公告)日：2015-10-15

申请号：US14441587

申请日：2013-11-06

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Karel Johan Malan ,  Paul Gauché

IPC: F24J2/52

CPC classification number: F24S25/30 ,  F24S20/20 ,  F24S23/77 ,  F24S25/10 ,  F24S25/16 ,  F24S25/70 ,  F24S2023/87 ,  Y02E10/47

Abstract: A support structure (10) for carrying a plurality of heliostats (12) is provided. The support structure (10) includes a frame (20) formed from a number of girders (22). The frame has a triangular outer perimeter and a plurality of mountings (26) for carrying the heliostats (12) are provided along the perimeter. At least one mounting (26) is provided at or near each vertex (16) of the triangular outer perimeter of the frame (20), and at least one additional mounting (26) is provided part-way along each side (17) of the triangular outer perimeter of the frame (20).

Abstract translation: 提供了用于承载多个定日镜（12）的支撑结构（10）。 支撑结构（10）包括由多个桁材（22）形成的框架（20）。 框架具有三角形外周边，并且沿着周边设置有用于承载定日镜（12）的多个安装件（26）。 至少一个安装件（26）设置在框架（20）的三角形外周边的每个顶点（16）处或附近，并且至少一个附加安装件（26）沿着每个侧面（17）分开设置 框架（20）的三角形外周边。

公开(公告)号：US09072704B2

公开(公告)日：2015-07-07

申请号：US14044004

申请日：2013-10-02

Applicant: Stellenbosch University

Inventor： David Meyer

IPC: A61K31/167

CPC classification number: A61K31/167

Abstract: A new use for paracetamol in a method of treating glaucoma, which method comprises administering to a patient in need of such treatment 500 mg to 1000 mg of paracetamol in oral format 4 to 6 hourly. An ophthalmic solution is also provided containing between 0.1 to 5% of paracetamol which is administered as one to two drops in each eye 4 to 6 hourly. The ophthalmic solution further includes one or more of the following excipients: hydroxypropylmethylcellulose, benzalconium chloride, polyacrylic acid such as Teargel®.

Abstract translation: 用于治疗青光眼的方法中的扑热息痛的新用途，该方法包括向需要这种治疗的患者施用4mg至6小时的口服剂型500mg至1000mg的扑热息痛。 还提供了一种眼用溶液，其含有0.1至5％的扑热息痛，每小时1至2滴滴注每只眼睛。 眼用溶液还包括一种或多种以下赋形剂：羟丙基甲基纤维素，氯化亚苄基铝，聚丙烯酸如Teargel。

公开(公告)号：US20150030566A1

公开(公告)日：2015-01-29

申请号：US14380518

申请日：2013-08-22

Applicant: Stellenbosch University

Inventor： Marina Rautenbach ,  Abré De Beer ,  Anscha Mari Troskie ,  Johan Arnold Vosloo

IPC: A01N43/713 ,  A01N63/02

CPC classification number: A01N43/713 ,  A01N37/46 ,  A01N43/90 ,  A01N63/02 ,  C07K7/64 ,  C07K7/66

Abstract: Compositions containing one or more tyrocidines, tryptocidines, phenycidines and/or gramicidin S, or derivatives and analogues thereof, are described for controlling antimicrobial growth on plants, plant material or plant growth media, and methods for controlling or preventing the growth of microbial pathogens, and in particular fungal pathogens, on plants, plant parts and plant material are described herein. The active agents used to control these pathogens are tyrocidines, tryptocidines, phenycidines and/or gramicidin S, or derivatives, analogues or modifications thereof. The tyrocidines, tryptocidines, phenycidines and/or gramicidin S are cyclic decapeptides having the general amino acid sequence cyclo(valine-Xrleucine-D-phenylalanine-proline-X2-X3-X4-X5-X6) (SEQ ID NO: 1) or a derivative or analogue thereof, wherein X1 is ornithine or lysine, X2 is valine, leucine, isoleucine, phenylalanine, tryptophan or tyrosine; X3 is the D-isomer of valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine, ornithine, or lysine; X4 is asparagine, glutamine or leucine; X5 is glutamine, the D-isomer of valine, leucine, or isoleucine; and X6 is tyrosine, phenylalanine, tryptophan or proline.

Abstract translation: 用于控制植物，植物材料或植物生长培养基上的抗微生物生长的方法和用于控制或预防微生物病原体生长的方法被描述为含有一种或多种酪氨酸，色氨酸，苯菌胺和/或短杆菌肽S或其衍生物和类似物的组合物， 特别是真菌病原体，在植物，植物部分和植物材料上。 用于控制这些病原体的活性剂是酪氨酸，色氨酸，苯菌胺和/或短杆菌肽S，或其衍生物，类似物或修饰物。 酪氨酸，色氨酸，phenycidines和/或短杆菌肽S是具有一般氨基酸序列环（缬氨酸-γ-亮氨酸-D-苯丙氨酸 - 脯氨酸-X2-X-X4-X5-X6）（SEQ ID NO：1）的环状十肽或 其衍生物或类似物，其中X1是鸟氨酸或赖氨酸，X2是缬氨酸，亮氨酸，异亮氨酸，苯丙氨酸，色氨酸或酪氨酸; X3是缬氨酸，亮氨酸，异亮氨酸，苯丙氨酸，色氨酸，酪氨酸，鸟氨酸或赖氨酸的D-异构体; X4是天冬酰胺，谷氨酰胺或亮氨酸; X5是谷氨酰胺，缬氨酸，亮氨酸或异亮氨酸的D-异构体; X6是酪氨酸，苯丙氨酸，色氨酸或脯氨酸。

公开(公告)号：US20140308724A1

公开(公告)日：2014-10-16

申请号：US14178653

申请日：2014-02-12

Applicant: Stellenbosch University ,  Mascoma Corporation

Inventor： Elena BREVNOVA ,  John E. McBride ,  Erin Wiswall ,  Kevin S. Wenger ,  Nicky Caiazza ,  Heidi Hau ,  Aaron Argyros ,  Frank Agbogbo ,  Charles F. Rice ,  Trisha Barrett ,  John S. Bardsley ,  Abigail Foster ,  Anne K. Warner ,  Mark Mellon ,  Ryan Skinner ,  Indraneel Shikhare ,  Riaan Den Haan ,  Chhayal V. Gandhi ,  Alan Belcher ,  Vineet B. Rajgarhia ,  Allan C. Froehlich ,  Kristen M. Deleault ,  Emily Stonehouse ,  Shital A. Tripathi ,  Jennifer Gosselin ,  Yin-Ying Chiu ,  Haowen Xu

IPC: C12P7/06 ,  C12N9/24

CPC classification number: C12N15/52 ,  C12N9/2405 ,  C12N9/2437 ,  C12N9/2445 ,  C12N9/248 ,  C12N9/2482 ,  C12N15/81 ,  C12P7/06 ,  C12Y302/01004 ,  C12Y302/01008 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/17

Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock.

Abstract translation: 本发明涉及分泌全套或全套的酶的酵母菌株或菌株，以水解玉米淀粉，玉米纤维，木质纤维素（包括水解纤维素中的连接酶，半纤维素和 木质素和碳水化合物之间）并利用戊糖（木糖和阿拉伯糖）。 本发明还涉及在酵母中对于各种酶活性良好表达的蛋白质组。 所得菌株或菌株可以同时水解淀粉和纤维素。 所产生的菌株或菌株也可以代谢工程化以产生较少的甘油和吸收乙酸盐。 所得的菌株或菌株也可用于从颗粒淀粉生产乙醇而不液化。 所得到的菌株或菌株可以进一步用于减少在同时糖化和发酵（SSF）过程中水解生物质原料所需的外部酶的量，或者在当前蔗糖分解酶负载下在SSF期间提高乙醇的产率。 此外，本发明的多种酶可以在本发明的细胞中共表达以提供对生物质原料的协同消化作用。 在一些方面，表达不同异源糖分解酶的宿主细胞也可以共同共培养并用于从生物质原料生产乙醇。