公开(公告)号：US08435523B2

公开(公告)日：2013-05-07

申请号：US12773488

申请日：2010-05-04

Applicant: John Powell ,  Duncan Casson ,  Mark Maginn ,  Wei Liu ,  Sandeep Dutta ,  Andrea Best ,  Jerry A. Hall

Inventor： John Powell ,  Duncan Casson ,  Mark Maginn ,  Wei Liu ,  Sandeep Dutta ,  Andrea Best ,  Jerry A. Hall

IPC: A61K39/395 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/50 ,  C07K2317/53 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.

Abstract translation: 本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。 还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

公开(公告)号：US20130102558A1

公开(公告)日：2013-04-25

申请号：US13603006

申请日：2012-09-04

Applicant: Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

Inventor： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC: A61K31/7076 ,  A61K31/497 ,  A61K31/513 ,  A61P31/14 ,  A61K31/4709 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/7072 ,  A61K31/4725

CPC classification number: A61K38/07 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/473 ,  A61K31/513 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/06 ,  A61K38/12 ,  A61K45/06 ,  G06F17/10 ,  G06F19/12

Abstract: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).

公开(公告)号：US20130102525A1

公开(公告)日：2013-04-25

申请号：US13603022

申请日：2012-09-04

Applicant: Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

Inventor： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC: A61K31/7056 ,  A61P31/14 ,  A61K38/07

CPC classification number: A61K38/07 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/513 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.

公开(公告)号：US08364244B2

公开(公告)日：2013-01-29

申请号：US11286938

申请日：2005-11-23

Applicant: Sandeep Dutta ,  Jianying Li ,  John Howard Londt ,  Melissa L. Vass ,  Xiangyang Tang ,  Darin R. Okerlund ,  Jiang Hsieh

Inventor： Elisabeth Angelos ,  Sandeep Dutta ,  Jianying Li ,  John Howard Londt ,  Melissa L. Vass ,  Xiangyang Tang ,  Darin R. Okerlund ,  Jiang Hsieh

IPC: A61B5/05

CPC classification number: G06T11/005 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/503 ,  A61B8/08 ,  G06T2211/412

Abstract: Methods and systems for generating computed tomographic (CT) images from image data acquired during different biological cycles are provided. A computer is programmed to receive a plurality of scan data acquired during a gated acquisition window of each of a plurality of biological cycles, blend the scan data acquired during a first of the plurality of biological cycles with the scan data acquired during a second of the plurality of biological cycles, and construct a final image from the blended data.

Abstract translation: 提供了在不同生物循环期间从图像数据生成计算机断层摄影（CT）图像的方法和系统。 计算机被编程为接收在多个生物循环中的每一个的选通采集窗口期间采集的多个扫描数据，将在多个生物学循环中的第一个期间获取的扫描数据与在第二个 多个生物循环，并从混合数据构建最终图像。

公开(公告)号：US08280127B2

公开(公告)日：2012-10-02

申请号：US12198492

申请日：2008-08-26

Applicant: Sandeep Dutta ,  Beth Heckel ,  Maria-Magdalena Nay ,  Sardar Gautham

Inventor： Sandeep Dutta ,  Beth Heckel ,  Maria-Magdalena Nay ,  Sardar Gautham

IPC: G06K9/00

CPC classification number: G06T19/00 ,  G06T2210/41 ,  G06T2219/008 ,  G06T2219/028

Abstract: A system and method for analyzing three-dimensional image data are disclosed herein. The system includes a processor configured to generate an overview image of at least a portion of a patient. The processor is configured to generate a cross-sectional image including a cross-sectional view of the overview image. The processor is also configured to generate a statistical image showing a parameter value relating to the portion of the patient shown in the overview image. The system also includes a visual output device connected to the processor. The visual output device is configured to display the overview image, the cross-sectional image, and the statistical image generally simultaneously. Also, the overview image, the cross-sectional image, and the statistical image are interconnected such that an update, change, or input applied to any one of the images results in an update to one or more of the other images.

Abstract translation: 本文公开了一种用于分析三维图像数据的系统和方法。 该系统包括被配置为生成患者的至少一部分的概览图像的处理器。 处理器被配置为生成包括概览图像的横截面图的横截面图像。 处理器还被配置为生成显示与概览图像中显示的患者部分相关的参数值的统计图像。 该系统还包括连接到处理器的视觉输出设备。 视觉输出设备被配置为一般同时显示概览图像，横截面图像和统计图像。 此外，概览图像，横截面图像和统计图像被互连，使得应用于任何一个图像的更新，改变或输入导致对一个或多个其他图像的更新。

公开(公告)号：US20120243761A1

公开(公告)日：2012-09-27

申请号：US13425724

申请日：2012-03-21

Applicant: Robert F. Senzig ,  Ravikanth Avancha ,  Bijan Dorri ,  Sandeep Dutta ,  Steven J. Gray ,  Jiang Hsieh ,  John Irvin Jackson ,  Giridhar Jothiprasad ,  Paul Edgar Licato ,  Darin Robert Okerlund ,  Toshihiro Rifu ,  Saad Ahmed Sirohey ,  Basel Taha ,  Peter Michael Edic ,  Jerome Knoplioch ,  Rahul Bhotika

Inventor： Robert F. Senzig ,  Ravikanth Avancha ,  Bijan Dorri ,  Sandeep Dutta ,  Steven J. Gray ,  Jiang Hsieh ,  John Irvin Jackson ,  Giridhar Jothiprasad ,  Paul Edgar Licato ,  Darin Robert Okerlund ,  Toshihiro Rifu ,  Saad Ahmed Sirohey ,  Basel Taha ,  Peter Michael Edic ,  Jerome Knoplioch ,  Rahul Bhotika

IPC: G06K9/00 ,  A61B6/03

CPC classification number: G06T11/008 ,  A61B6/032 ,  A61B6/481 ,  A61B6/482 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5217 ,  A61B6/5294 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10081 ,  G06T2207/30104 ,  G06T2211/404

Abstract: A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Abstract translation: 使用CT成像估计血管流量的系统和方法包括其上存储有包括指令的计算机程序的计算机可读存储介质，所述计算机程序在由计算机执行时使计算机获取包含成像的解剖信息的第一组数据 解剖信息包括至少一个血管的信息。 指令还使计算机处理解剖信息以产生包括至少一个容器的图像体积，基于图像体积产生血液动力学信息，并获取成像对象的第二组数据。 还引起计算机根据第二组数据产生包括血液动力学信息与可视化结合的图像。

公开(公告)号：US08222278B2

公开(公告)日：2012-07-17

申请号：US12475440

申请日：2009-05-29

Applicant: Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

Inventor： Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

IPC: A61K31/44

CPC classification number: A61K31/4439

Abstract: 3-(5,6-Dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane and salts thereof are effective nicotinic receptor agonist compounds that demonstrated pharmacological effect for symptoms associated with attention-deficit/hyperactivity disorder.

Abstract translation: 3-（5,6-二氯 - 吡啶-3-基）-1S，5S-3,6-二氮杂双环[3.2.0]庚烷及其盐是有效的烟碱受体激动剂化合物，其表现出与注意力相关的症状的药理作用， 缺乏/多动障碍。

公开(公告)号：US08081809B2

公开(公告)日：2011-12-20

申请号：US11562505

申请日：2006-11-22

Applicant: Sandeep Dutta ,  Saad Ahmed Sirohey ,  Gopal B. Avinash ,  John V. Skinner ,  Patricia Le Nezet ,  DeAnn Marie Haas ,  Sardar Mal Gautham ,  Mukta C. Joshi

Inventor： Sandeep Dutta ,  Saad Ahmed Sirohey ,  Gopal B. Avinash ,  John V. Skinner ,  Patricia Le Nezet ,  DeAnn Marie Haas ,  Sardar Mal Gautham ,  Mukta C. Joshi

IPC: G06K9/00

CPC classification number: G06T11/006 ,  A61B6/032 ,  A61B6/583

Abstract: Methods and apparatus for reconstructing a multiple resolution images of an object are provided. The method includes reconstructing a first three-dimensional image at a first resolution, determining at least one volume of interest in the generated image, and reconstructing a second three-dimensional image of the determined at least one volume of interest at a second resolution, the second resolution being higher than the first resolution such that a quantification of image structures is facilitated.

Abstract translation: 提供了用于重建对象的多个分辨率图像的方法和装置。 该方法包括以第一分辨率重建第一三维图像，确定生成的图像中的至少一个感兴趣的体积，以及以第二分辨率重建所确定的至少一个感兴趣体积的第二三维图像， 第二分辨率高于第一分辨率，使得图像结构的量化变得容易。

公开(公告)号：US20110200241A1

公开(公告)日：2011-08-18

申请号：US12705672

申请日：2010-02-15

Applicant: Arunabha Roy ,  Sandeep Dutta ,  Srikanth Suryanarayanan ,  Umesha Perdoor Srinivas Adiga

Inventor： Arunabha Roy ,  Sandeep Dutta ,  Srikanth Suryanarayanan ,  Umesha Perdoor Srinivas Adiga

IPC: G06K9/48 ,  G06T7/00 ,  G06K9/40

CPC classification number: G06T7/0012 ,  G06T5/008 ,  G06T7/187 ,  G06T2207/10081 ,  G06T2207/20036 ,  G06T2207/30061

Abstract: A system and method includes acquisition of a set of image data comprising a plurality of image voxels and isolation of a set of pulmonary emboli candidates from the plurality of image voxels. The system and method also includes application of a non-linear contrast enhancement to the set of pulmonary emboli candidates, filtration of the enhanced set of pulmonary emboli candidates, output of a final set of pulmonary emboli candidates, and creation of an image comprising the final set of pulmonary emboli candidates.

Abstract translation: 一种系统和方法包括获取包括多个图像体素的一组图像数据并从多个图像体素中分离一组肺栓塞候选物。 该系统和方法还包括对一组肺栓塞候选者应用非线性对比度增强，过滤增强的肺栓塞候选者组，输出最终的肺栓塞候选者，以及创建包括最终 一套肺栓塞候选人。

公开(公告)号：US07774040B1

公开(公告)日：2010-08-10

申请号：US10250268

申请日：2003-06-19

Applicant: Sandeep Dutta ,  Aleksandar Zavaljevski ,  Roy Nilsen ,  Darin R. Okerland ,  Rajendra Kurady

Inventor： Sandeep Dutta ,  Aleksandar Zavaljevski ,  Roy Nilsen ,  Darin R. Okerland ,  Rajendra Kurady

IPC: A61B5/05

CPC classification number: A61B6/032 ,  A61B6/503 ,  A61B6/541

Abstract: A method and apparatus for multi-phase cardiac CT imaging includes an adaptive, selective reconstruction process that, when possible, implements an image or non-phase location driven reconstruction process to reconstruct cardiac CT images. If the hardware parameters support an image location driven reconstruction for the particular imaging session then the image location driven reconstruction is implemented. However, if image location driven reconstruction is not supported, a default phase location driven reconstruction is employed. Image location driven reconstruction improves system throughput and improves image quality as more cardiac phase locations can routinely be generated to better “freeze” the motion of the heart of a patient.

Abstract translation: 用于多相心脏CT成像的方法和装置包括自适应选择性重建过程，其在可能的情况下实现图像或非相位置驱动的重建过程以重建心脏CT图像。 如果硬件参数支持特定成像会话的图像位置驱动的重建，则实现图像位置驱动的重建。 然而，如果不支持图像位置驱动重建，则采用默认的相位位置驱动重构。 图像位置驱动重建可以提高系统吞吐量并提高图像质量，因为可以定期产生更多的心脏相位位置，以更好地“冻结”患者心脏的运动。