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41.发明授权公开(公告)号：US10584159B2
公开(公告)日：2020-03-10
申请号：US15512267
申请日：2015-09-21
Applicant: The Royal Institution for the Advancement of Learning/McGill University , Université de Montréal
Inventor： Stéphane Alain Laporte , Yoon Namkung , Michel Bouvier , Christian Le Gouill , Mireille Hogue , Viktoriya Lukasheva , Hiroyuki Kobayashi , Denis Deblois , Étienne Durette
Abstract: Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.
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公开(公告)号：US10569225B2
公开(公告)日：2020-02-25
申请号：US14779446
申请日：2014-03-27
Applicant: National Research Council of Canada , The Royal Institution for the Advancement of Learning/McGill University
Inventor： Kebin Li , Teodor Veres , Tohid Fatanat Didar , Maryam Tabrizian
Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
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公开(公告)号：US20200030356A1
公开(公告)日：2020-01-30
申请号：US16538139
申请日：2019-08-12
Applicant: Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts , The Royal Institution for the Advancement of Learning/McGill University
Inventor： Pouria JANDAGHI , Yasser RIAZ ALHOSSEINI , Daniel Scott AULD , Veena SANGWAN
IPC: A61K31/7068 , G01N33/574 , A61K31/40 , A61P35/00
Abstract: The present disclosure provides a novel method for treating pancreatic cancer and pancreatitis. The disclosure pertains to antagonists of dopamine receptors, that when combined with a glycolysis inhibitor, and a cholesterol lowering agent inhibit the growth of pancreatic cells.
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公开(公告)号：US10527908B2
公开(公告)日：2020-01-07
申请号：US16411208
申请日：2019-05-14
Inventor： Patanjali Kambhampati
Abstract: There is described a method of tuning an output optical pulse. The method generally has: generating a seed optical pulse, the seed optical pulse having a tunable parameter; propagating the seed optical pulse into and along one of a plurality of optical fibers each having a hollow core extending along a given length, the optical fibers having a parameter being different from one another; pumping a gas inside the hollow core of the one of the optical fibers, said pumping having a tunable parameter; the propagation of the seed optical pulse into and along the one of the optical fibers modifying the seed optical pulse into the output optical pulse; and tuning the output optical pulse by modifying the tunable parameter of the seed optical pulse, modifying the one of the optical fibers along which the seed optical pulse is propagated and modifying the tunable parameter of said pumping.
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公开(公告)号：US20200002825A1
公开(公告)日：2020-01-02
申请号：US16453010
申请日：2019-06-26
Inventor： Srinivas VANKA , Zetian MI
Abstract: There is described a silicon photoanode generally having a silicon-based substrate; and a protective layer covering the silicon-base substrate, the protective layer having a transition metal dichalcogenide (TMDC) material, being uniform and having a thickness below about 8 nm.
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Patent Agency Ranking
公开(公告)号：US10407556B2
公开(公告)日：2019-09-10
申请号：US15317151
申请日：2015-06-11
Inventor： Marta Cerruti , Hesameddin Mahjoubi
Abstract: Many different substrates are used in tissue engineering as platforms to enhance cell attachment, proliferation and activity, either in-vitro, to multiply specific cell lines, or in-vivo, to induce shorter healing time of injured or missing tissue. However, their hydrophobicity and lack of specific functionalities make them non-ideal for cell adhesion and growth. Treating the surfaces by exposing them to a series of steps including, but not limited to, a diazonium based wet chemistry allows one or more functional groups to be applied to the surface improving cell adhesion and growth. Embodiments of the invention exploiting PDLLA, PMMA and roughed PEEK are demonstrated including both a one-stage and a two-stage process, and at times a vacuum treatment, allowing modification of inner and outer surfaces.
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公开(公告)号：US10390162B2
公开(公告)日：2019-08-20
申请号：US15516053
申请日：2015-10-06
Inventor： Peter Gaskell , Robert-Eric Gaskell , Thomas Szkopek , Jung Wook Hong
Abstract: The method can include depositing a graphene oxide containing material from solution to form a laminar nano-structure of graphene oxide paper, and assembling at least a portion of the graphene oxide paper as a diaphragm of the acoustic transducer. The acoustic transducer can be a magnetic induction based microphone, a diaphragm loudspeaker, or a magnetic induction based loudspeaker, for instance.
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公开(公告)号：US10328092B2
公开(公告)日：2019-06-25
申请号：US15178138
申请日：2016-06-09
Inventor： David Stellwagen , Gil Moshe Lewitus
IPC: A61K31/7028 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36
Abstract: Methods of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and/or reducing development of behavioral sensitization or suppressing drug induced behavioral sensitization in a subject, optionally a subject that is afflicted with an addiction, the method comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist or a composition comprising said TLR4 agonist, preferably wherein the TLR4 agonist is a monophosphoryl lipid A (MPLA).
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公开(公告)号：US20190190545A1
公开(公告)日：2019-06-20
申请号：US16213452
申请日：2018-12-07
Inventor： Warren GROSS , Gabi SARKIS , Pascal GIARD
CPC classification number: H03M13/617 , H03M13/09 , H03M13/13 , H03M13/451 , H03M13/611 , H03M13/6561
Abstract: Methods and systems for encoding data are described herein. The method comprises inputting data to a first pipeline of a non-systematic polar encoder capable of encoding a polar code of length nmax, extracting, via at least one first multiplexer of size log nmax×1, a first polar code of length n
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公开(公告)号：US20190120787A1
公开(公告)日：2019-04-25
申请号：US16163621
申请日：2018-10-18
Inventor： Thomas SZKOPEK , Ibrahim FAKIH
IPC: G01N27/414 , H01L29/16
Abstract: There is described a sensor for sensing a variable of a sample. The sensor generally has a graphene layer supported by a substrate; a parylene layer coating the graphene layer opposite the substrate; a sensing layer coating the parylene layer opposite the substrate, and being exposable to the sample; and electrical contacts at opposite ends of the graphene layer.
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