公开(公告)号：US20220229022A1

公开(公告)日：2022-07-21

申请号：US17716436

申请日：2022-04-08

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Marc E. Lemelin ,  Sylvain Gilles Cormier

IPC: G01N30/18 ,  B01D15/14 ,  G01N30/24

Abstract: A seal pack of a sample manager of a liquid chromatography system having a plurality of wash flow pathways fluidically connected to a central pathway that accommodates a sample needle, wherein a first wash flow pathway is vertically offset from a second wash flow pathway, such that a wash solution flows axially along an exterior surface of the sample needle in a vertical direction to wash the sample needle when flowing from the first wash flow pathway to the vertically offset second wash flow pathway, is provided. Furthermore, an autosampler and associated methods are also provided.

公开(公告)号：US20220203360A1

公开(公告)日：2022-06-30

申请号：US17335373

申请日：2021-06-01

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung

IPC: B01L3/00

Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.

公开(公告)号：US11340198B2

公开(公告)日：2022-05-24

申请号：US16425057

申请日：2019-05-29

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Theodore A. Dourdeville

IPC: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/60

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

公开(公告)号：US20220128526A1

公开(公告)日：2022-04-28

申请号：US17513003

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Sylvain G. Cormier ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Joseph D. Antocci

IPC: G01N30/60 ,  B01D15/22

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

公开(公告)号：US20220082532A1

公开(公告)日：2022-03-17

申请号：US17471449

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/16 ,  G01N30/86 ,  G01N30/72 ,  G01N30/74

Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

公开(公告)号：US11273390B2

公开(公告)日：2022-03-15

申请号：US16570534

申请日：2019-09-13

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Pamela C. Iraneta ,  Joseph A. Luongo ,  Joseph A. Jarrell

IPC: B01D15/22 ,  B01D15/16 ,  B01D15/20 ,  G01N30/30 ,  G01N30/54 ,  G01N30/88 ,  G01N30/02

Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.

公开(公告)号：US20220065711A1

公开(公告)日：2022-03-03

申请号：US17523667

申请日：2021-11-10

Applicant: Waters Technologies Corporation

Inventor： Robert L. Danley

IPC: G01K17/00 ,  G01K19/00 ,  G01K7/02

Abstract: A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided. The method includes calculating a heat exchange between a plurality of sample containers and a reference container placed on a plurality of sample calorimeter units and a reference calorimeter unit, respectively, and determining a heat flow rate of samples within the sample containers using the calculated heat exchange between the plurality of sample containers and the reference container. A multiple sample differential scanning calorimeter sensor and calorimeter system are also provided.

公开(公告)号：US20220011276A1

公开(公告)日：2022-01-13

申请号：US17358391

申请日：2021-06-25

Applicant: Waters Technologies Corporation

Inventor： Fabrice Gritti

IPC: G01N30/06 ,  G01N30/16

Abstract: A mixer arrangement for use in a chromatography system includes a first frequency targeting mixer including a first flow channel coupled between an inlet and an outlet and a second flow channel coupled between the inlet and the outlet, the second flow channel including a volume offset region configured to delay fluid propagation through the second flow channel, wherein the volume offset region is configured to reduce or eliminate fluidic compositional oscillations in a compositional solvent stream that depart from a desired composition at a first target frequency, and a residual noise targeting mixer fluidically connected in series to the frequency targeting mixer, the residual noise targeting mixer configured to dampen aperiodic baseline noise in the compositional solvent stream.

公开(公告)号：US11204293B2

公开(公告)日：2021-12-21

申请号：US16420845

申请日：2019-05-23

Applicant: Waters Technologies Corporation

Inventor： Gary W. Bertone ,  Taylor J. Castagna ,  Robert J. Dumas

IPC: G01L9/04 ,  G01L9/00 ,  G01L19/04 ,  G01N30/32 ,  G01N30/64

Abstract: Disclosed is a pressure transducer including a body made of a material having a first coefficient of thermal expansion, a fluidic inlet and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet. The pressure transducer further includes a strain gauge including a resistive element in operable contact with the body. At least a portion of the resistive element made of a material having a second coefficient of thermal expansion that is different from the first coefficient of thermal expansion of the body. Disclosed further is a pressure transducer including a filler body located in a fluidic cavity of the pressure transducer configured to reduce adiabatic thermal effects on a transducer body. Disclosed are systems and methods incorporating the pressure transducers described herein.

公开(公告)号：US20210388022A1

公开(公告)日：2021-12-16

申请号：US17314748

申请日：2021-05-07

Applicant: Waters Technologies Corporation

Inventor： Xiaoxiao Liu ,  Wenjing Li ,  Matthew A. Lauber

IPC: C07K1/113 ,  C07C279/04 ,  C12Q1/37 ,  C07D487/04

Abstract: The present disclosure relates to a system for a composition for protein denaturation. The composition includes a non-nucleophilic denaturant comprising a substituted guanidine, wherein the denaturant has a pKa value greater than about 10, and wherein the concentration of the substituted guanidine is less than 250 mM.