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公开(公告)号：US20210205011A1
公开(公告)日：2021-07-08
申请号：US17127151
申请日：2020-12-18
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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公开(公告)号：US10881312B2
公开(公告)日：2021-01-05
申请号：US16577327
申请日：2019-09-20
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Vartan Ghazarossian , Steven Almany , Michael Sasha John
IPC: A61B3/02 , A61B5/04 , A61M31/00 , A61B5/00 , A61B18/14 , A61B17/32 , A61B5/20 , A61B18/18 , A61B18/00 , A61B18/02 , A61B18/04 , A61M25/00 , A61B90/00 , A61B18/12 , A61B17/00
Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.
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公开(公告)号：US20200061348A1
公开(公告)日：2020-02-27
申请号：US16509995
申请日：2019-07-12
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
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公开(公告)号：US20200022751A1
公开(公告)日：2020-01-23
申请号：US16039234
申请日：2018-07-18
Applicant: Ablative Solutions, Inc.
Inventor： Andy Edward Denison , David R. Fischell , Tim A. Fischell , Darrin James Kent , Nicole Haratani
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple penetrators advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, nerve sensing, nerve stimulation, or ablation by application of energy. The catheter can include a proximal handle for the advancement of guide tubes and penetrators.
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公开(公告)号：US20190076188A1
公开(公告)日：2019-03-14
申请号：US15947626
申请日：2018-04-06
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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Patent Agency Ranking
公开(公告)号：US20190076187A1
公开(公告)日：2019-03-14
申请号：US15947619
申请日：2018-04-06
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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公开(公告)号：US20190076186A1
公开(公告)日：2019-03-14
申请号：US15947618
申请日：2018-04-06
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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48.发明授权公开(公告)号：US10226278B2
公开(公告)日：2019-03-12
申请号：US14841662
申请日：2015-08-31
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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公开(公告)号：US09949652B2
公开(公告)日：2018-04-24
申请号：US14963179
申请日：2015-12-08
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Vartan Ghazarossian , Steven Almany , Michael Sasha John
IPC: A61B3/02 , A61B5/04 , A61M31/00 , A61B5/00 , A61B18/14 , A61B17/32 , A61B5/20 , A61B18/18 , A61B18/00 , A61B18/02 , A61B18/04 , A61M25/00 , A61B90/00 , A61B18/12 , A61B17/00
CPC classification number: A61B5/04001 , A61B5/201 , A61B5/4035 , A61B5/6848 , A61B5/6852 , A61B17/320068 , A61B18/0218 , A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2017/00039 , A61B2018/00214 , A61B2018/00404 , A61B2018/00434 , A61B2018/00541 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00738 , A61B2018/00779 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00875 , A61B2018/00892 , A61B2018/00898 , A61B2018/00916 , A61B2018/0212 , A61B2018/046 , A61B2018/048 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1467 , A61B2018/1475 , A61B2090/376 , A61B2090/3966 , A61M2025/0095
Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.
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公开(公告)号：US20170332926A1
公开(公告)日：2017-11-23
申请号：US15663409
申请日：2017-07-28
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Vartan Ghazarossian , Steven Almany , Michael Sasha John
IPC: A61B5/04 , A61B18/14 , A61B5/00 , A61B18/04 , A61B18/02 , A61B18/00 , A61M25/00 , A61B18/18 , A61B18/12 , A61B17/32 , A61B5/20 , A61B90/00 , A61B17/00
CPC classification number: A61B5/04001 , A61B5/201 , A61B5/4035 , A61B5/6848 , A61B5/6852 , A61B17/320068 , A61B18/0218 , A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2017/00039 , A61B2018/00214 , A61B2018/00404 , A61B2018/00434 , A61B2018/00541 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00738 , A61B2018/00779 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00875 , A61B2018/00892 , A61B2018/00898 , A61B2018/00916 , A61B2018/0212 , A61B2018/046 , A61B2018/048 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1467 , A61B2018/1475 , A61B2090/376 , A61B2090/3966 , A61M2025/0095
Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.
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