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41.发明授权公开(公告)号：US11692220B2
公开(公告)日：2023-07-04
申请号：US17027433
申请日：2020-09-21
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore , Byron J. Knight
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6482 , G01N2021/6484
Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with multiple receptacle wells. Each well has a through-hole extending from an inner surface of the well to an outer surface of the holder. A cover is rotatable between an open position and a closed position relative to the holder and is configured to exert a force onto any receptacles in the wells when the cover is in the closed position. The apparatus includes multiple optical fibers, and each of the optical fibers provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A thermal element is positioned between a thermally-conductive support and the receptacle holder.
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公开(公告)号：US11487959B2
公开(公告)日：2022-11-01
申请号：US17220954
申请日：2021-04-02
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky
Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
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公开(公告)号：US11275914B2
公开(公告)日：2022-03-15
申请号：US16905816
申请日：2020-06-18
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky , Rolf Silbert
Abstract: A method for reading machine-readable labels on a plurality of sample receptacles held by a sample rack. The sample rack is moved between first and second positions within a housing and a label reader is activated at each of a plurality of predetermined position between the first and second positions to read the machine-readable label of each of the plurality of sample receptacles.
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44.发明授权公开(公告)号：US11230733B2
公开(公告)日：2022-01-25
申请号：US17025735
申请日：2020-09-18
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore , Byron J. Knight
Abstract: Receptacles containing a reaction mixture are transported to receptacle wells of a thermally conductive receptacle holder, and the temperature of the holder is cycled with a thermoelectric device situated between a support and a first side of the holder while a first force is applied onto a second side of the holder. Optical communication between each well and an excitation signal source and an emission signal detector is established to determine whether an emission signal is emitted from any of the receptacles during temperature cycling as an indication of the presence of a target nucleic acid. The thermoelectric device may be situated between an upright portion of the support and the first side of the holder. A second force may be applied onto a top end of each receptacle in the holder by a cover moveable with respect to the receptacles between an open position and a closed position.
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公开(公告)号：US20210324445A1
公开(公告)日：2021-10-21
申请号：US17146110
申请日：2021-01-11
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
Abstract: A diagnostic system is configured to perform first and second, different nucleic acid amplification reactions. The system includes a bulk reagent container compartment configured to store first bulk reagent container containing a first bulk reagent for performing sample preparation processes with a first subset and a second subset of a plurality of samples and a second bulk reagent container containing a second bulk reagent for performing the first nucleic acid amplification reaction. The system includes a unit-dose reagent compartment storing a unit-dose reagent pack including unit-dose reagents for performing the second nucleic acid amplification reaction. The system is configured to perform the sample preparation process using the first bulk reagent on the first and second subsets of the samples, perform the first nucleic acid amplification reaction using the second bulk reagent on the first subset of the samples, and perform the second nucleic acid amplification reaction using the unit-dose reagents on the second subset of the samples.
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Patent Agency Ranking
公开(公告)号：US11136617B2
公开(公告)日：2021-10-05
申请号：US17036307
申请日：2020-09-29
Applicant: Gen-Probe Incorporated
Inventor： Byron J. Knight , David A. Buse , Norbert D. Hagen , David Opalsky , Tyler Moore , Anita Prasad , Bruce Richardson
Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.
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公开(公告)号：US10970504B2
公开(公告)日：2021-04-06
申请号：US16052448
申请日：2018-08-01
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky
Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
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公开(公告)号：US10889851B2
公开(公告)日：2021-01-12
申请号：US16829230
申请日：2020-03-25
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , Norbert D. Hagen , Byron J. Knight , Tyler Moore , David Opalsky , Anita Prasad , Bruce Richardson
Abstract: A method for moving a processing vial between locations of an instrument. The method includes the steps of dispensing a fluid into a processing vial with a disposable pipette tip frictionally fitted onto a probe of a pipettor, stripping the disposable pipette tip from the probe of the pipettor, and then engaging a cap in a frictional fit with the probe of the pipettor. While the cap is engaged in a frictional fit with the probe of the pipettor, coupling the cap to the processing vial to form a cap/vial assembly, where the cap seals the processing vial. The pipettor moves the cap/vial assembly from a first location of an instrument to a second location of the instrument. At the second location of the instrument, the cap/vial assembly is ejected from the probe of the pipettor, thereby depositing the cap/vial assembly at the second location.
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49.发明授权公开(公告)号：US10190984B2
公开(公告)日：2019-01-29
申请号：US15389897
申请日：2016-12-23
Applicant: Gen-Probe Incorporated
Inventor： David Opalsky , Srajan Raghuwanshi , James Bui
Abstract: A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.
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公开(公告)号：US10146973B2
公开(公告)日：2018-12-04
申请号：US15092150
申请日：2016-04-06
Applicant: Gen-Probe Incorporated
Inventor： Norbert D. Hagen , David Opalsky , Rolf Silbert
Abstract: Systems for reading machine-readable labels, for example, two-dimensional barcodes, include a housing, a reader configured to read the machine-readable labels on sample receptacles as a sample rack holding the sample receptacles move between a first position and a second position within the housing. The system includes a processing and control unit configured to decode a read image of the machine-readable labels on each sample receptacle, and configured to associate a decoded read images with the corresponding sample receptacles based on measured positions of the sample rack when the machine-readable label was read.
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