公开(公告)号：US20090069333A1

公开(公告)日：2009-03-12

申请号：US12187072

申请日：2008-08-06

Applicant: Patrick Jelf Crowley ,  Markus Dobler ,  Urs Mueller ,  John Williams

Inventor： Patrick Jelf Crowley ,  Markus Dobler ,  Urs Mueller ,  John Williams

IPC: A01N43/58 ,  C07D471/04 ,  A01P3/00 ,  A01N43/60

CPC classification number: C07D471/04

Abstract: This invention relates to novel derivatives of pyridopyrazines and pyridopyridazines, to processes for preparing them, to intermediate chemicals used in their manufacture, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants. The fungicidal compounds have the general formula (1) wherein R, R1, R2, W, X Y and Z are defined in the specification

Abstract translation: 本发明涉及吡啶并吡嗪和吡啶并哒嗪的新衍生物，其制备方法，制备中使用的中间体化学品，含有它们的组合物以及使用它们来对抗真菌，特别是植物真菌感染的方法。 杀真菌化合物具有通式（1），其中R，R 1，R 2，W，X Y和Z在本说明书中定义

公开(公告)号：US20080318962A1

公开(公告)日：2008-12-25

申请号：US11570980

申请日：2005-06-21

Applicant: Patrick Jelf Crowley ,  Urs Muller ,  Markus Dobler ,  John Williams

Inventor： Patrick Jelf Crowley ,  Urs Muller ,  Markus Dobler ,  John Williams

IPC: A01N43/90 ,  C07D471/04 ,  A01P3/00

CPC classification number: C07D471/04 ,  A01N43/90

Abstract: The compound of the general formula (I), wherein W, X, Y, Z, R, R1 and R2 are defined as set forth in the specification, useful as fungicide.

Abstract translation: 通式（I）的化合物，其中W，X，Y，Z，R，R 1和R 2定义如说明书中所述，可用作杀真菌剂。

公开(公告)号：US07424333B2

公开(公告)日：2008-09-09

申请号：US11313868

申请日：2005-12-20

Applicant: John Williams ,  Scott Bahneman ,  Adrian King

Inventor： John Williams ,  Scott Bahneman ,  Adrian King

IPC: G06F17/00

CPC classification number: H04S7/40 ,  H04S3/008

Abstract: An audio fidelity meter includes a scale which uses colors to visually represent the fidelity of an encoded digital audio file based at least on its extracted bit rate. The bit rate is one of several digital audio quality descriptors. Other descriptors include format, source, bit width, and sample rate. The extracted bit rate is fed into a lookup table for processing. One or more of the other descriptors can also be extracted and fed in combination with the extracted bit rate into the lookup table for processing. The lookup table stores information on various digital audio formats, sources and associated bit rates, bit widths and sample rates in the form of a database. The input bit width, sample rate, format, originating source and/or bit rate is/are compared against the database to generate a digital audio quality output. The output may be visually displayed via the scale, a fidelity meter needle and an associated numerical bit rate display.

Abstract translation: 音频保真度表包括至少基于其提取的比特率使用颜色来视觉地表示编码数字音频文件的保真度的刻度。 比特率是几个数字音频质量描述符之一。 其他描述符包括格式，源，位宽和采样率。 提取的比特率被馈送到查找表中进行处理。 还可以提取一个或多个其他描述符并将其与提取的比特率一起馈送到查找表中进行处理。 查找表以数据库的形式存储关于各种数字音频格式，来源和相关比特率，比特宽度和采样率的信息。 将输入位宽度，采样率，格式，发源和/或比特率与数据库进行比较以生成数字音频质量输出。 可以通过刻度，保真度计针和相关联的数字比特率显示来可视地显示输出。

公开(公告)号：US20080113900A1

公开(公告)日：2008-05-15

申请号：US11901983

申请日：2007-09-20

Applicant: Nicola Brasch ,  Catherine Birch ,  John Williams

Inventor： Nicola Brasch ,  Catherine Birch ,  John Williams

IPC: A61K38/06 ,  A61P25/00 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00

CPC classification number: A61K38/063 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, glutathionylcobalamin to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as glutathionylcobalamin, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

Abstract translation: 治疗应用，如预防，治疗和补充，用于使用新型和其他硫胺素类维生素来保护人类细胞免受氧化应激的影响。 特别地，本发明涉及一种新的合成硫胺素类巴马酸，谷胱甘肽钴胺素保护动物细胞免受氧化应激损伤的用途。 本发明还涉及硫胺素类维生素如谷胱甘肽钴胺素代替当前市售形式的维生素B 12，用于治疗和预防与氧化应激损伤和膳食补充相关的病症。

公开(公告)号：US20070141863A1

公开(公告)日：2007-06-21

申请号：US11649052

申请日：2007-01-03

Applicant: John Williams

Inventor： John Williams

IPC: H01R12/00

CPC classification number: H01R12/52 ,  H01R4/04 ,  H01R12/57 ,  H01R13/2407 ,  H05K3/326 ,  H05K3/4015 ,  H05K3/4092

Abstract: A scalable, low cost, reliable, compliant, low profile, low insertion force, high-density, separable and reconnectable connector for high speed, high performance electronic circuitry and semiconductors. The electrical connector can be used to make, for example, electrical connections from components such as a Printed Circuit Board (PCB) to another PCB, MPU, NPU, or other semiconductor device. A normalized working range for an array of elastic contacts of the interposer can be about 0.2 to 1.0. A reversible normalized working range is maintained through multiple connections and reconnections using a highly elastic material for the contact arms. In one aspect, a first electrical component having a first array pitch can be connected to a second electrical component having a second array pitch.

Abstract translation: 适用于高速，高性能电子电路和半导体的可扩展，低成本，可靠，兼容，低外形，低插入力，高密度，可分离和可重新连接的连接器。 电连接器可以用于例如从诸如印刷电路板（PCB）到另一PCB，MPU，NPU或其它半导体器件的组件的电连接。 插入器的弹性接触阵列的归一化工作范围可以为约0.2至1.0。 通过使用用于接触臂的高弹性材料的多个连接和重新连接来维持可逆的归一化工作范围。 在一个方面，具有第一阵列间距的第一电气部件可以连接到具有第二阵列间距的第二电气部件。

公开(公告)号：US20070129382A1

公开(公告)日：2007-06-07

申请号：US10597788

申请日：2005-02-09

Applicant: Dimitri Grigoriadis ,  Deborah Slee ,  John Williams

Inventor： Dimitri Grigoriadis ,  Deborah Slee ,  John Williams

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in warm-blooded animals. CRF receptor antagonists which are labeled with a positron emitting isotope for use in PET are also disclosed.

Abstract translation: 公开了CRF受体拮抗剂，其可用于治疗多种疾病，包括治疗在温血动物中表现出CRF过度分泌的疾病。 还公开了用用于PET的正电子发射同位素标记的CRF受体拮抗剂。

公开(公告)号：US20070125548A1

公开(公告)日：2007-06-07

申请号：US11605945

申请日：2006-11-28

Applicant: John Williams

Inventor： John Williams

IPC: E21B33/06 ,  E21B33/08

CPC classification number: E21B33/085

Abstract: A high-pressure stripper rubber provides inserts and support members that cooperatively support the profile of the rubber against elastic deformation. The inserts dynamically cooperate to resist elastic deformation of the rubber due to down hole pressure. The stripper rubber has a generally cylindrical upper moiety and a dynamic, generally frusto-conical, lower moiety that cooperatively define a bore for receiving oilfield equipment. A generally ring-shaped adapter insert, at least partially within the stripper rubber, is disposed toward the upper moiety for attaching the stripper rubber to drilling head equipment. A structural retention insert assembly provides (1) one or more support members proximately, movably and selectively attached to the adapter insert, and (2) one or more structural retention inserts at least partially within the stripper rubber and distally attached to the one or more support members. The stripper rubber dynamically forms a self-actuating, fluid-tight seal around varying outer diameters of oil field equipment as the equipment is tripped through the stripper rubber bore with minimal deformation of the rubber, even under high pressure.

公开(公告)号：US20070066605A1

公开(公告)日：2007-03-22

申请号：US10540040

申请日：2003-12-04

Applicant: Patrick Crowley ,  Markus Dobler ,  Urs Mueller ,  John Williams

Inventor： Patrick Crowley ,  Markus Dobler ,  Urs Mueller ,  John Williams

IPC: C07D487/02 ,  A01N43/90

CPC classification number: C07D239/42 ,  A01N43/90 ,  C07D471/04

Abstract: Fungicidal compositions having the general formula (1): formula (1) wherein W and Y are both N and X and Z are both CR8 or X and Z are both N and W and Y are both C6, R8 is H, halo, C1-4 alkyl, C1-4alkoxy or halo(C1-4)alkyl; R and R2 are independently H, halo, C1-8alkyl, C1-8alkoxy, C1-8alkylthio, C2-8alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one of R and R2 is NR3R4; R1 is halo, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-8cycloalkyl, C3-8cycloalkyl(C1-6)-alkyl, C1-8alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(CI4,)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)alkylthio, heteroaryl(C1-4)alkylthiio, morpholiiio, piperidino or pynrolidino.

Abstract translation: 具有通式（1）：式（1）的杀真菌组合物，其中W和Y都是N，X和Z都是CR 8或X和Z都是N，W和Y都是C R 8是H，卤素，C 1-4烷基，C 1-4烷氧基或卤代 （C 1-4烷基）烷基; R和R 2独立地为H，卤素，C 1-8烷基，C 1-8烷氧基，C 1-8 C 2〜C 8烷基，C 2-8链烯基，C 2-8炔基，氰基或NR 3 R 4， SUP>，条件是R和R 2中的至少一个是NR 3 R 4; R 1是卤素，C 1-8烷基，C 2-8链烯基，C 2-8炔基 C 3-8环烷基，C 3-8环烷基（C 1-6 - ） - 烷基，C 1-8 - C 1-4烷基，芳基，芳氧基，芳硫基，杂芳基，杂芳氧基，杂芳硫基，芳基（C 1-4 - ）烷基，芳基（C 1-4， ）烷氧基，杂芳基（C 1-4 - ）烷基，杂芳基（C 1-4 - ）烷氧基，芳基（C 1-4 - ）烷硫基 ，杂芳基（C 1-4烷基）硫代，吗啉代，哌啶子基或鸟嘌呤基。

公开(公告)号：US20070048748A1

公开(公告)日：2007-03-01

申请号：US11234677

申请日：2005-09-23

Applicant: John Williams ,  Jon Anderson ,  Teresa Urlacher ,  David Steffens

Inventor： John Williams ,  Jon Anderson ,  Teresa Urlacher ,  David Steffens

IPC: C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/22 ,  C12N15/74 ,  C12N1/21

CPC classification number: C12N9/1252

Abstract: The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.

Abstract translation: 本发明涉及在聚合过程中具有改变的掺入磷酸酯标记的核苷酸的动力学的新型突变型DNA聚合酶的发现。 本发明还涉及这些突变型DNA聚合酶在测序和基因分型方法中的用途。

公开(公告)号：US20070020960A1

公开(公告)日：2007-01-25

申请号：US11445285

申请日：2006-06-02

Applicant: John Williams

Inventor： John Williams

IPC: H01R12/00

CPC classification number: H01R12/52 ,  H01R4/04 ,  H01R12/57 ,  H01R13/2407 ,  H05K3/326 ,  H05K3/4015 ,  H05K3/4092

Abstract: A scalable, low cost, reliable, compliant, low profile, low insertion force, high-density, separable and reconnectable connector for high speed, high performance electronic circuitry and semiconductors. The electrical connector can be used to make, for example, electrical connections from components such as a Printed Circuit Board (PCB) to another PCB, MPU, NPU, or other semiconductor device. A normalized working range for an array of elastic contacts of the interposer can be about 0.2 to 1.0. A reversible normalized working range is maintained through multiple connections and reconnections using a highly elastic material for the contact arms. In one aspect, a first electrical component having a first array pitch can be connected to a second electrical component having a second array pitch.

Abstract translation: 适用于高速，高性能电子电路和半导体的可扩展，低成本，可靠，兼容，低外形，低插入力，高密度，可分离和可重新连接的连接器。 电连接器可以用于例如从诸如印刷电路板（PCB）到另一PCB，MPU，NPU或其它半导体器件的组件的电连接。 插入器的弹性接触阵列的归一化工作范围可以为约0.2至1.0。 通过使用用于接触臂的高弹性材料的多个连接和重新连接来维持可逆的归一化工作范围。 在一个方面，具有第一阵列间距的第一电气部件可以连接到具有第二阵列间距的第二电气部件。