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    Blends of poly(ester amide) polymers
    41.
    发明授权
    Blends of poly(ester amide) polymers 有权
    聚（酯酰胺）聚合物的共混物

    公开(公告)号：US07166680B2

    公开(公告)日：2007-01-23

    申请号：US10960381

    申请日：2004-10-06

    Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

    Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

    IPC: A61L27/34 ,  A61L29/00 ,  C08L77/12

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

    Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    MRI compatible stent
    42.
    发明授权
    MRI compatible stent 有权
    MRI兼容支架

    公开(公告)号：US06712844B2

    公开(公告)日：2004-03-30

    申请号：US09876756

    申请日：2001-06-06

    Applicant: Stephen Dirk Pacetti

    Inventor： Stephen Dirk Pacetti

    IPC: A61F206

    CPC classification number: A61F2/86 ,  A61B2090/3954 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0032 ,  A61F2250/0043 ,  A61L31/124 ,  A61L31/18

    Abstract: An expandable metallic stent has discontinuities of non-conducting material. These eliminate electrically conducting paths in the stent rings and cells. This makes the stent easier to image with magnetic resonance imaging (MRI). The non-conducting material can include adhesives, polymers, ceramics, composites, nitrides, oxides, silicides, and carbides. The discontinuity is preferably shaped so that during expansion the discontinuity is placed in primarily a compressive stress.

    Abstract translation: 可扩展金属支架具有不导电材料的不连续性。 这些消除了支架环和细胞中的导电路径。 这使得支架更容易用磁共振成像（MRI）进行成像。 非导电材料可以包括粘合剂，聚合物，陶瓷，复合材料，氮化物，氧化物，硅化物和碳化物。 不连续性优选地成形为使得在膨胀期间，不连续性主要被置于压缩应力中。

    Interdigitating polymeric endcap for enhanced stent retention
    43.
    发明授权
    Interdigitating polymeric endcap for enhanced stent retention 有权
    交叉聚合端帽，用于增强支架保留

    公开(公告)号：US06585747B1

    公开(公告)日：2003-07-01

    申请号：US09548802

    申请日：2000-04-14

    Applicant: Timothy A. Limon ,  Stephen Dirk Pacetti

    Inventor： Timothy A. Limon ,  Stephen Dirk Pacetti

    IPC: A61B1734

    CPC classification number: A61F2/958 ,  A61F2002/9583

    Abstract: A stent deployment assembly with a novel endcap is disclosed. The endcap includes a tapered member having a first end and a second end. The first end and the second end each have an aperture therethrough. The tapered member has a pre-expanded condition and an expanded condition. The first end of the tapered member is positioned to interdigitate with an end of a stent mounted on a catheter when the tapered member is in the pre-expanded condition, and the first end is not positioned overlying the stent. The endcap prevents the stent from catching on calcium deposits or foreign objects during navigation through the vasculature. Furthermore, the endcap prevents unwanted migration of the stent with respect to the catheter.

    Abstract translation: 公开了一种具有新型端盖的支架展开组件。 端盖包括具有第一端和第二端的锥形构件。 第一端和第二端各自具有穿过其中的孔。 锥形构件具有预膨胀状态和膨胀状态。 当锥形构件处于预膨胀状态时，锥形构件的第一端定位成与安装在导管上的支架的端部相互指向，并且第一端不位于支架上方。 端盖防止支架在通过脉管系统导航期间捕获钙沉积物或异物。 此外，端盖防止支架相对于导管的不期望的迁移。

    MRI medical device markers utilizing fluorine-19
    44.
    发明授权
    MRI medical device markers utilizing fluorine-19 有权
    使用氟-19的MRI医疗器械标记

    公开(公告)号：US06574497B1

    公开(公告)日：2003-06-03

    申请号：US09746843

    申请日：2000-12-22

    Applicant: Stephen Dirk Pacetti

    Inventor： Stephen Dirk Pacetti

    IPC: A61M2500

    CPC classification number: G01R33/285 ,  A61B90/39 ,  A61B2090/3954 ,  A61F2/01 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/075 ,  A61L29/18 ,  A61L31/18 ,  A61M25/0127

    Abstract: Medical devices that incorporate compounds containing fluorine-19 materials for use as contrast agents and passive markers in interventional magnetic resonance angiography. The device may be a guidewire, guiding catheter, angioplasty catheter, stent, embolic protection device, endovascular graft, endotracheal tube, Foley catheter, Hickman catheter, Broviac catheter, cerebrospinal fluid shunt, biliary stent, stylet, biopsy needle, electrode, percutaneous or endoluminal transducer or other desired interventional medical device. The fluorine-19 material may be configured from an elastomer, a fluid, a fluorosilicone, or a perfluorocarbon grease or oil. Such materials may be incorporated into marker bands and/or stripes, or may be deposited into or dispersed within the walls or lumens of the medical device to be visualized. Use of fluorine-19 containing markers and contrast agents provide a novel method of performing angioplasty and deploying stents, grafts, embolic protection and other such devices using interventional magnetic resonance angiography.

    Abstract translation: 包含氟-19材料的化合物的医疗装置用作介入性磁共振血管造影剂中的造影剂和被动标记物。 该装置可以是导丝，引导导管，血管成形术导管，支架，栓塞保护装置，血管内移植物，气管内导管，Foley导管，Hickman导管，Broviac导管，脑脊液分流，胆管支架，探针，活检针，电极，经皮或 腔内换能器或其他所需的介入医疗装置。 氟-19材料可以由弹性体，流体，氟硅氧烷或全氟化碳润滑脂或油构成。 这样的材料可以并入到标记带和/或条纹中，或者可以沉积到或分散在待显现的医疗装置的壁或腔内。 使用含氟-19的标记物和造影剂提供了使用介入磁共振血管造影术进行血管成形术和部署支架，移植物，栓塞保护和其它这样的装置的新方法。

    Drug-eluting stent and delivery system with tapered stent in shoulder region
    47.
    发明授权
    Drug-eluting stent and delivery system with tapered stent in shoulder region 有权
    药物洗脱支架和带锥形支架的递送系统在肩部区域

    公开(公告)号：US08343206B2

    公开(公告)日：2013-01-01

    申请号：US13285627

    申请日：2011-10-31

    Applicant: Stephen Dirk Pacetti

    Inventor： Stephen Dirk Pacetti

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0067 ,  Y10T29/49826

    Abstract: A drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent.

    Abstract translation: 药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个包括锥形部分 锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。 药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分 气囊的第二端由锥形药物洗脱支架覆盖。

    Drug-eluting stent and delivery system with tapered stent in shoulder region
    49.
    发明授权
    Drug-eluting stent and delivery system with tapered stent in shoulder region 有权
    药物洗脱支架和带锥形支架的递送系统在肩部区域

    公开(公告)号：US08057526B2

    公开(公告)日：2011-11-15

    申请号：US11646781

    申请日：2006-12-28

    Applicant: Stephen Dirk Pacetti

    Inventor： Stephen Dirk Pacetti

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0067 ,  Y10T29/49826

    Abstract: A drug-eluting stent delivery system for the treatment of edge restenosis in a blood vessel. The drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent contacts a wall of the blood vessel to maintain the patency of the vessel. The drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent. A method for making the same is also disclosed herein.

    Abstract translation: 用于治疗血管中边缘再狭窄的药物洗脱支架递送系统。 药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个 锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。 药物洗脱支架接触血管的壁以维持血管的通畅。 药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分 气囊的第二端由锥形药物洗脱支架覆盖。 本文还公开了制备该方法的方法。

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