公开(公告)号：US11965693B2

公开(公告)日：2024-04-23

申请号：US17126036

申请日：2020-12-18

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Yeon Suk Choi ,  Myung Su Kim

IPC: F25B9/10 ,  F17C13/00 ,  F25J1/00 ,  F25J1/02 ,  H01F6/04

CPC classification number: F25J1/0007 ,  F17C13/007 ,  F25B9/10 ,  F25J1/0237 ,  F25J1/0279 ,  H01F6/04 ,  F25B2400/17 ,  F25J2215/30 ,  F25J2270/30 ,  F25J2290/30

Abstract: Disclosed are a helium gas liquefier and a method for liquefying a helium gas. The disclosed helium gas liquefier includes: a first cooling part including a first cooling column; a first cold head installed on the first cooling column, and a first cylinder in which the first cooling column and the first cold head are built; a second cooling part including a second cooling column, a second cold head installed on the second cooling column, and a second cylinder in which the second cooling column and the second cold head are built; and a liquid helium storage disposed under the second cooling part.

公开(公告)号：US11531023B2

公开(公告)日：2022-12-20

申请号：US16169020

申请日：2018-10-24

Applicant: Korea Basic Science Institute

Inventor： Gun H. Kim ,  Edmond C. Park ,  Seung I. Kim ,  Sang-Yeop Lee

IPC: C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  A61K31/7088 ,  C07K16/18 ,  G16H50/20 ,  G16B20/00 ,  G16B40/00

Abstract: The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.

公开(公告)号：US20220382041A1

公开(公告)日：2022-12-01

申请号：US17641770

申请日：2020-09-09

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  INSTITUTE FOR BASIC SCIENCE ,  GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： I Jong Kim ,  Ji Yong Bae ,  Hong Seung Kim ,  Geon Hee Kim ,  Ki Soo Chang ,  Cheonha Jeon ,  Il Woo Choi ,  Chang Hee Nam

IPC: G02B26/06 ,  G02B26/08

Abstract: A spiral phase plate, according to one embodiment, for generating a Laguerre Gaussian beam by reflecting an incident beam emitted from a light source, may comprise: a first quadrant area in which the step height increase rate per unit angle decreases progressively in one direction from the point with the lowest step height to the point with the highest step height; and a second quadrant area in which the step height increase rate per unit angle increases progressively in the one direction.

公开(公告)号：US20220294013A1

公开(公告)日：2022-09-15

申请号：US17654358

申请日：2022-03-10

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Hae Jin KIM ,  Won Gi HONG ,  Jong Pil KIM ,  In Jun JEON

IPC: H01M10/0565 ,  H01M10/0525 ,  H01M10/058 ,  H01M4/131 ,  H01M4/133

Abstract: The disclosure relates a to manufacturing method of an all-solid-state lithium secondary battery including a solid polymer electrolyte, including preparing an all-solid-state lithium secondary battery by interposing a polymer electrolyte between a cathode and an anode; hardening the polymer electrolyte by applying a pressure and heat to the all-solid-state lithium secondary battery; activating the all-solid-state lithium secondary battery by applying a current; and removing a gas generated in the activated all-solid-state lithium secondary battery. By hardening a polymer electrolyte interposed between a cathode and an anode through applying a pressure and heat, a bubble or dead area inside solid polymer electrolyte is minimized with providing an electrode having uniform thickness. By repeating activation operation and removing gas, bonding of electrode stack is more enhanced, and stability of a battery is improved.

公开(公告)号：US11424446B2

公开(公告)日：2022-08-23

申请号：US16182890

申请日：2018-11-07

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Yeon Ho Kim ,  Hae Jin Kim ,  Won Gi Hong ,  Jong Guk Kim

IPC: H01M4/52 ,  H01M10/0525 ,  H01M4/62 ,  H01M50/411 ,  H01M4/02

Abstract: Provided are an anode active material for secondary battery which includes porous iron oxide nanoparticles, a manufacturing method thereof, and a secondary battery including the same. The anode active material for secondary battery of the present disclosure minimizes a volume change of iron oxide caused by intercalation and deintercalation of lithium even during consecutive charges and discharges and thus can improve the capacity and lifespan characteristics of a secondary battery employing the anode active material. Further, the manufacturing method of an anode active material for secondary battery makes it possible to manufacture an anode active material for secondary battery including iron oxide nanoparticles in an environmentally friendly and simple manner and thus makes it possible to mass-produce the anode active material.

公开(公告)号：US20220218726A1

公开(公告)日：2022-07-14

申请号：US17416883

申请日：2019-12-19

Applicant: Korea Basic Science Institute

Inventor： Gun Hwa Kim ,  Min Ji Lee ,  Koon Soon Kim ,  Hyo Kyun Chung ,  Ji Hoon Lee ,  Se Jin Jung ,  Da Rong Kim

IPC: A61K31/635

Abstract: The present invention relates to a composition comprising a CYP4A-inhibiting compound as an active ingredient for preventing or treating metabolic diseases, more specifically to a composition comprising the compound expressed by chemical formula 1 of the present invention or pharmaceutically acceptable salt thereof as an active ingredient for preventing, ameliorating or treating metabolic diseases.

公开(公告)号：US11193988B2

公开(公告)日：2021-12-07

申请号：US16687213

申请日：2019-11-18

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA BASIC SCIENCE INSTITUTE

Inventor： Kyoung-Woong Moon ,  Chan Yong Hwang ,  Byoung-Chul Min ,  Seung-young Park

IPC: G01R33/05 ,  H01F10/30 ,  G01R33/12 ,  G01R33/00 ,  G01R33/032 ,  H01F10/32

Abstract: Provided is a method of measuring a magnitude of magnetization of a perpendicular magnetic thin film, including: forming a stripe pattern in which a first magnetic domain that extends in a y direction and is magnetized in a z direction and a second magnetic domain that extends in the y direction and is magnetized in a direction opposite to the z direction are arranged alternately in an x direction, in a perpendicular magnetic thin film that extends in an xy plane; changing widths in the x direction, of the first and second magnetic domains by applying a magnetic field having a predetermined magnitude, in the z direction, to the perpendicular magnetic thin film; and calculating an absolute value of the magnetization of the perpendicular magnetic thin film on the basis of a ratio between the widths in the x direction, of the first magnetic domain and the second magnetic domain.

公开(公告)号：US11181531B2

公开(公告)日：2021-11-23

申请号：US16078333

申请日：2017-12-15

Applicant: Korea Basic Science Institute

Inventor： Gun Wook Park ,  Jong Shin Yoo ,  Jin Young Kim ,  Ju Yeon Lee ,  Hyun Kyoung Lee

IPC: G01N33/68 ,  G16B50/00

Abstract: The present invention relates to a bioinformation processing analysis method for the identification and quantification of O-linked glycopeptide using high resolution mass spectrum. Particularly, according to the bioinformation processing analysis method of the present invention, the quantitative changes of O-linked glycopeptide containing non-informed sugar chains included in various samples can be efficiently and accurately analyzed; the prediction or diagnosis of disease including cancer can be made easy by using a high resolution mass spectrometer; or the investigation of O-linked glycopeptide structure of a therapeutic glycoprotein can be efficiently achieved.

公开(公告)号：US20210293702A1

公开(公告)日：2021-09-23

申请号：US15734902

申请日：2019-08-29

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Kye Sung LEE ,  Ki Soo CHANG

IPC: G01N21/45 ,  G02B21/00 ,  G02B21/26 ,  G02B21/18 ,  G01N21/25 ,  G01N21/64

Abstract: A compound microscope system, according to one embodiment, may comprise: a sample holder for supporting a sample; an optical interference microscope module for transferring a broadband light towards the sample and a reference mirror, and forming a tomographic image of the sample on the basis of a spectrum image formed by the mutual interference between lights reflected from the sample and the reference mirror; and a nonlinear microscope module for forming a nonlinear image of the sample by irradiating a laser pulse towards the sample, and then measuring an excitation light comprising excited multiphoton.

公开(公告)号：US11101457B2

公开(公告)日：2021-08-24

申请号：US16182954

申请日：2018-11-07

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： You Na Ko ,  Hae Jin Kim ,  Won Gi Hong ,  Jin Bae Lee

IPC: H01M4/36 ,  H01M4/587 ,  H01M4/58 ,  H01M4/02

Abstract: The present disclosure provides a process for the production of a cathode active material complex which is used for a lithium secondary battery, comprising the steps of: mixing a lithium metal phosphate with a solvent to prepare a first precursor; mixing the first precursor with a graphene oxide to prepare a second precursor solution; forming droplets from the second precursor solution; and making the droplets into a powder; wherein the formation of the powder is performed by spray pyrolysis method.