公开(公告)号：US5066809A

公开(公告)日：1991-11-19

申请号：US589307

申请日：1990-09-27

Applicant: Dev D. Suresh ,  Robert DiCosimo ,  Richard Loiseau ,  Maria S. Friedrich ,  Hsiao-Chiung Szabo

Inventor： Dev D. Suresh ,  Robert DiCosimo ,  Richard Loiseau ,  Maria S. Friedrich ,  Hsiao-Chiung Szabo

IPC: B01J23/62 ,  B01J23/652 ,  B01J23/89 ,  C07B61/00 ,  C07D213/08 ,  C07D213/16

CPC classification number: C07D213/08

Abstract: Disclosed is a process for making 3-methylpyridine by contacting 2-methylglutaronitrile in admixture with hydrogen gas with a supported solid catalyst containing palladium metal promoted with at least one of Cr, W, Ni, Co and Ge.

Abstract translation: 公开了一种通过使2-甲基戊二腈与氢气混合的载体与包含Cr，W，Ni，Co和Ge中的至少一种促进的钯金属的载体固体催化剂接触来制备3-甲基吡啶的方法。

公开(公告)号：US08518675B2

公开(公告)日：2013-08-27

申请号：US11943872

申请日：2007-11-21

Applicant: Robert DiCosimo ,  John E. Gavagan ,  Mark S. Payne ,  Frederick B. Cooling, III

Inventor： Robert DiCosimo ,  John E. Gavagan ,  Mark S. Payne ,  Frederick B. Cooling, III

IPC: C12P7/40 ,  C12N9/14

CPC classification number: C12P7/40 ,  A61L2/186 ,  C12P7/62

Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

Abstract translation: 提供了从羧酸酯制备过氧羧酸的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢在具有过水解活性的酶催化剂存在下反应。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂。

公开(公告)号：US20130089900A1

公开(公告)日：2013-04-11

申请号：US13692254

申请日：2012-12-03

Applicant: Keith H. Burlew ,  Robert Dicosimo ,  Michael Charles Grady

Inventor： Keith H. Burlew ,  Robert Dicosimo ,  Michael Charles Grady

IPC: C12P7/16

CPC classification number: C12P7/16 ,  A23K10/38 ,  B01D3/002 ,  B01D11/0492 ,  B01D21/26 ,  B01D21/262 ,  C07C29/86 ,  C11B1/025 ,  C11B13/00 ,  C12F3/10 ,  C12M1/00 ,  C12M21/12 ,  C12M45/04 ,  C12M45/09 ,  C12N1/14 ,  C12N15/00 ,  C12P7/18 ,  C12P7/6418 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02W30/74

Abstract: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be hydrolyzed by contacting the feedstock including the oil with one or more enzymes whereby at least a portion of the oil is hydrolyzed into free fatty acids forming a fermentation product extractant, or the oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be contacted with the enzymes to form the fermentation product extractant. The fermentation product extractant can be contacted with a fermentation broth for in situ removal of a product alcohol.

公开(公告)号：US08394617B2

公开(公告)日：2013-03-12

申请号：US13328390

申请日：2011-12-16

Applicant: Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

Inventor： Robert DiCosimo ,  Mark Scott Payne ,  John Edward Gavagan

IPC: C12N9/18 ,  C12P7/40 ,  A61L9/00

CPC classification number: C12N9/18 ,  C12Y301/01072

Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

公开(公告)号：US08389575B2

公开(公告)日：2013-03-05

申请号：US13354486

申请日：2012-01-20

Applicant: Robert DiCosimo ,  Mark Scott Payne ,  Eugenia Costa Hann

Inventor： Robert DiCosimo ,  Mark Scott Payne ,  Eugenia Costa Hann

IPC: A01N37/00 ,  C12P7/40 ,  C12N9/14

CPC classification number: C12N9/18 ,  C11D3/0047 ,  C11D3/38636 ,  C11D3/38681 ,  C11D3/3945 ,  C11D3/48

Abstract: A process is provided for producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity under conditions where control of reaction pH by selection of buffer concentration and concentration of perhydrolase and reactants produces a targeted concentration of peroxycarboxylic acids. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided, as are corresponding methods of use.

Abstract translation: 提供了从羧酸酯生产过氧羧酸的目标浓度的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢反应，在具有过水解活性的酶催化剂的存在下，通过选择缓冲液浓度和过水解酶和反应物的浓度来控制反应pH产生目标浓度 的过氧羧酸。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂，以及相应的使用方法。

公开(公告)号：US20130004479A1

公开(公告)日：2013-01-03

申请号：US13609504

申请日：2012-09-11

Applicant: Robert Dicosimo ,  Arie Ben-Bassat ,  William R. Cahill ,  David George Dipietro ,  Eugenia Costa Hann ,  Mark S. Payne ,  Richard Alan Reynolds ,  Raymond Richard Zolandz

Inventor： Robert Dicosimo ,  Arie Ben-Bassat ,  William R. Cahill ,  David George Dipietro ,  Eugenia Costa Hann ,  Mark S. Payne ,  Richard Alan Reynolds ,  Raymond Richard Zolandz

IPC: D06L3/11 ,  C12S11/00 ,  C11D3/60 ,  C12S9/00 ,  A01N37/16 ,  A01P1/00

CPC classification number: C12N9/18 ,  A61L2/183 ,  A61L2/186 ,  A61L2/22 ,  A61L2202/24 ,  C11D3/06 ,  C11D3/10 ,  C11D3/201 ,  C11D3/2017 ,  C11D3/2044 ,  C11D3/2048 ,  C11D3/2068 ,  C11D3/2079 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/2093 ,  C11D3/221 ,  C11D3/226 ,  C11D3/32 ,  C11D3/361 ,  C11D3/38636 ,  C11D3/3947 ,  C11D17/041 ,  C12P7/40 ,  C12Y301/01001 ,  Y02E50/16

Abstract: Disclosed herein are multi-component formulations for enzymatically producing aqueous solutions of peroxycarboxylic acids suitable for use in, e.g., disinfectant and/or bleaching applications. The multi-component peroxycarboxylic acid formulations comprise at least one carbohydrate esterase family 7 enzyme having perhydrolytic activity.

Abstract translation: 本文公开了用于酶促生产适用于例如消毒剂和/或漂白应用的过氧羧酸的水溶液的多组分制剂。 多组分过氧羧酸制剂包含至少一种具有过水解活性的碳水化合物酯酶家族7酶。

公开(公告)号：US08334120B2

公开(公告)日：2012-12-18

申请号：US13248260

申请日：2011-09-29

Applicant: Robert Dicosimo ,  Mark S. Payne ,  Tyler Yin

Inventor： Robert Dicosimo ,  Mark S. Payne ,  Tyler Yin

IPC: C12P7/40 ,  C12N9/00 ,  C12N9/16 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC classification number: C12N9/18 ,  A61L2/183 ,  A61L2/186 ,  A61L2/22 ,  A61L2202/24 ,  C11D3/06 ,  C11D3/10 ,  C11D3/201 ,  C11D3/2017 ,  C11D3/2044 ,  C11D3/2048 ,  C11D3/2068 ,  C11D3/2079 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/2093 ,  C11D3/221 ,  C11D3/226 ,  C11D3/32 ,  C11D3/361 ,  C11D3/38636 ,  C11D3/3947 ,  C11D17/041 ,  C12P7/40 ,  C12Y301/01001 ,  Y02E50/16

Abstract: Disclosed herein are variants enzymes that are structurally classified as CE-7 enzymes and have perhydrolysis activity. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned variant enzymes as well as methods and compositions comprising the variant enzymes. Further, disinfectant formulations comprising the peroxycarboxylic acids produced by the processes described herein are provided.

Abstract translation: 本文公开了在结构上分类为CE-7酶并具有过水解活性的变体酶。 本文还公开了使用上述变体酶从羧酸酯生产过氧羧酸的方法以及包含变体酶的方法和组合物。 此外，提供包含通过本文所述方法产生的过氧羧酸的消毒剂制剂。

公开(公告)号：US08298808B2

公开(公告)日：2012-10-30

申请号：US12497384

申请日：2009-07-02

Applicant: Robert DiCosimo ,  John Edward Gavagan ,  Mark Scott Payne ,  Frederick B. Cooling

Inventor： Robert DiCosimo ,  John Edward Gavagan ,  Mark Scott Payne ,  Frederick B. Cooling

IPC: C12N1/20 ,  C12P7/40 ,  C12N9/14

CPC classification number: C11D3/38636 ,  A01N37/16 ,  C11D3/2093 ,  C11D3/221 ,  C11D3/226 ,  C11D3/3947 ,  C11D3/48 ,  C12P7/40 ,  A01N37/02 ,  A01N37/12 ,  A01N37/46 ,  A01N43/16 ,  A01N59/00 ,  A01N61/00 ,  A01N2300/00

Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

公开(公告)号：US08293792B2

公开(公告)日：2012-10-23

申请号：US12722302

申请日：2010-03-11

Applicant: Robert Dicosimo ,  John Edward Gavagan ,  Mark Scott Payne ,  Frederick B. Cooling, III

Inventor： Robert Dicosimo ,  John Edward Gavagan ,  Mark Scott Payne ,  Frederick B. Cooling, III

IPC: A01N37/00 ,  C12P7/40 ,  C12N9/14

CPC classification number: A01N37/02 ,  A01N37/16 ,  A01N37/36 ,  A01N59/00 ,  A61L2/186 ,  C12P7/40 ,  C12P7/62 ,  A01N63/02 ,  A01N2300/00

Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

公开(公告)号：US08288136B2

公开(公告)日：2012-10-16

申请号：US12538525

申请日：2009-08-10

Applicant: Robert DiCosimo ,  John Edward Gavagan ,  Mark S. Payne

Inventor： Robert DiCosimo ,  John Edward Gavagan ,  Mark S. Payne

IPC: C12P7/42 ,  C12N9/18 ,  C12N9/104

CPC classification number: A01N37/16 ,  C11D3/2093 ,  C11D3/221 ,  C11D3/226 ,  C11D3/38636 ,  C11D3/3947 ,  C11D3/48 ,  C12P7/40 ,  C12P7/42 ,  A01N37/02 ,  A01N37/12 ,  A01N37/46 ,  A01N43/16 ,  A01N59/00 ,  A01N61/00 ,  A01N2300/00

Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.