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    Methods of ablating tissue using a catheter injection system
    51.
    发明授权
    Methods of ablating tissue using a catheter injection system 有权

    公开(公告)号：US09795441B2

    公开(公告)日：2017-10-24

    申请号：US14814962

    申请日：2015-07-31

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61B18/14 ,  A61M5/00 ,  A61B18/00

    CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/143 ,  A61M5/00

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.

    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION
    52.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 审中-公开
    膀胱注射和肌肉和神经纤维的放大导管系统

    公开(公告)号：US20160235464A1

    公开(公告)日：2016-08-18

    申请号：US14994681

    申请日：2016-01-13

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61B18/06 ,  A61B5/042 ,  A61B18/14 ,  A61B90/00

    CPC classification number: A61B18/06 ,  A61B5/042 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/22038 ,  A61B2017/22068 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00285 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/3966 ,  A61M2025/0087

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

    Abstract translation: 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针穿入左心房壁或主动脉壁的距离的构件。 本发明还具有重要的应用，用于消除一个或两个肾动脉周围的组织，用于消除去往或来自每个肾脏的交感神经纤维和/或其他传入或传出神经以治疗高血压。

    EXPANDABLE CATHETER SYSTEM FOR FLUID INJECTION INTO AND DEEP TO THE WALL OF A BLOOD VESSEL
    55.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR FLUID INJECTION INTO AND DEEP TO THE WALL OF A BLOOD VESSEL 审中-公开
    用于流体注射进入和深入到血管壁的可扩展导管系统

    公开(公告)号：US20150343156A1

    公开(公告)日：2015-12-03

    申请号：US14738776

    申请日：2015-06-12

    Applicant: ABLATIVE SOLUTIONS, INC.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M5/46 ,  A61M25/06 ,  A61M25/00

    CPC classification number: A61M5/46 ,  A61B5/6848 ,  A61M25/0026 ,  A61M25/0084 ,  A61M25/0097 ,  A61M25/0662 ,  A61M2025/0039 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0681 ,  A61M2202/0007 ,  A61M2205/0266 ,  A61M2210/12

    Abstract: A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

    Abstract translation: 应用于肾去神经支配的基于导管的/血管内流体注射系统包括多个针，其围绕中心轴线敞开，以与血管的壁或左心房的壁接合，允许注射细胞毒性和 或用于烧蚀导管组织的神经毒性溶液，或肺静脉口周围的神经纤维，或在肾动脉的外层周围或周边。 可扩展递送系统包括可扩展部件，其有助于将多个注射针定位在血管的内壁上，从而可以将其推进。 该系统还包括限制和/或调节烧蚀液体渗透到目标血管壁的组织中的深度的装置。

    METHODS OF ABLATING TISSUE USING A CATHETER INJECTION SYSTEM
    56.
    发明申请
    METHODS OF ABLATING TISSUE USING A CATHETER INJECTION SYSTEM 有权
    使用导管注射系统分解组织的方法

    公开(公告)号：US20150335384A1

    公开(公告)日：2015-11-26

    申请号：US14814962

    申请日：2015-07-31

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61B18/14 ,  A61M5/00

    CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/143 ,  A61M5/00

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.

    Abstract translation: 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针头进入左心房壁的距离的成员。 本发明还可用于消除肾动脉口周围的组织用于治疗高血压。

    PERI-VASCULAR TISSUE ABLATION CATHETERS
    60.
    发明申请
    PERI-VASCULAR TISSUE ABLATION CATHETERS 有权

    公开(公告)号：US20210220044A1

    公开(公告)日：2021-07-22

    申请号：US17173536

    申请日：2021-02-11

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden

    IPC: A61B18/14 ,  A61B17/34 ,  A61M25/00 ,  A61B90/00 ,  A61B18/04

    Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

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