公开(公告)号：US20180235808A1

公开(公告)日：2018-08-23

申请号：US15956195

申请日：2018-04-18

Applicant: Avedro, Inc.

Inventor： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

IPC: A61F9/008 ,  A61F9/007 ,  A61N5/06 ,  A61B3/10 ,  A61B18/00 ,  A61B3/107

CPC classification number: A61F9/008 ,  A61B3/102 ,  A61B3/107 ,  A61B2018/00619 ,  A61F9/0079 ,  A61F2009/00844 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/00882 ,  A61N5/062 ,  A61N2005/0659 ,  A61N2005/0661

Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

公开(公告)号：US09707126B2

公开(公告)日：2017-07-18

申请号：US13665495

申请日：2012-10-31

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Pavel Kamaev ,  Evan Sherr ,  William Eddington ,  Sara Rood-Ojalvo ,  David Muller

IPC: A61M37/00 ,  A61F9/00 ,  A61F9/007 ,  A61N5/06 ,  A61K41/00 ,  A61K31/525 ,  A61F9/013 ,  A61F9/008

CPC classification number: A61F9/0008 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61K31/525 ,  A61K41/00 ,  A61N5/062

Abstract: A method for controlling activation of Riboflavin applied to an eye includes applying the Riboflavin to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the Riboflavin with pulsed light illumination. The pulsed light illumination has an irradiance, dose, and an on/off duty cycle. The irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for Riboflavin cross-linking activity and to control photochemical efficiency.

公开(公告)号：US20170156926A1

公开(公告)日：2017-06-08

申请号：US15369647

申请日：2016-12-05

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Desmond Adler

IPC: A61F9/00 ,  A61M13/00 ,  A61N5/06

CPC classification number: A61F9/0026 ,  A61F9/008 ,  A61F9/04 ,  A61F2009/00872 ,  A61M13/00 ,  A61M2202/0208 ,  A61N5/062 ,  A61N2005/0648 ,  A61N2005/0661 ,  A61N2005/067

Abstract: An eye treatment positions a mask device over first and second eyes. A posterior side of the mask device is proximate to the face and the anterior side is distal from the face. The mask device includes an outer wall extending between the anterior and posterior sides and defining a chamber extending across the first and second eyes. The anterior side includes a first transmission region that allows a photoactivating light for the first eye to be delivered into a first section of the chamber positioned over the first eye. The anterior side includes a second transmission region that allows a photoactivating light for the second eye to be delivered into the second section positioned over the second eye. The system includes at least one gas source storing a gas that is different than ambient air. The system includes a gas delivery system that delivers the gas into the chamber.

公开(公告)号：US09498122B2

公开(公告)日：2016-11-22

申请号：US14308678

申请日：2014-06-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/107 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10 ,  A61B5/00

CPC classification number: A61B3/107 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/113 ,  A61B3/14 ,  A61B5/0075 ,  G01J3/0213 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/4412

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US20160310758A1

公开(公告)日：2016-10-27

申请号：US15137748

申请日：2016-04-25

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Mikhail Smirnov ,  Pavel Kamaev

IPC: A61N5/06 ,  A61F9/00 ,  A61M35/00

CPC classification number: A61N5/0624 ,  A61F9/0079 ,  A61F9/029 ,  A61M2202/0208 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2205/52 ,  A61M2210/0612 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/0648 ,  A61N2005/0661

Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

Abstract translation: 抗微生物治疗系统包括可佩戴的光活化装置。 可穿戴光激活装置包括被配置为被放置在被摄体的头部上的主体的主体的一个或多个眼睛上。 身体包括允许一只或多只眼睛透过身体观察的一个或多个窗户或开口。 身体包括耦合到身体并被配置为根据照明参数将光激活光引导到一个或多个眼睛的一个或多个光活化光源。 照明参数确定光活化光的剂量，其根据光化学动力学反应激活施加到一个或多个眼睛上的光敏剂，并产生在一个或多个眼睛中提供抗微生物作用的活性氧，而基本上不诱导交联， 在一个或多个眼睛中产生生物力学变化的连接活动。

公开(公告)号：US20150265762A1

公开(公告)日：2015-09-24

申请号：US14696672

申请日：2015-04-27

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Pavel Kamaev ,  David Muller ,  Radha Pertaub ,  Ronald Scharf ,  Evan Sherr ,  David Usher

IPC: A61M5/00 ,  A61B3/14 ,  A61B5/00

CPC classification number: A61M5/007 ,  A61B3/10 ,  A61B3/107 ,  A61B3/135 ,  A61B3/145 ,  A61B5/0066 ,  A61B5/0071 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61K49/006 ,  A61M37/0092 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/0661 ,  A61N2005/067

Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.

Abstract translation: 用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。 提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。 示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。 系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

公开(公告)号：US20140276361A1

公开(公告)日：2014-09-18

申请号：US14216392

申请日：2014-03-17

Applicant: AVEDRO, INC.

Inventor： Satish Herekar ,  Marc D. Friedman ,  David Muller

IPC: A61N5/06 ,  A61B19/00 ,  A61F9/00 ,  A61K31/525 ,  A61K31/352

CPC classification number: A61N5/062 ,  A61B90/361 ,  A61B2090/306 ,  A61B2090/3735 ,  A61F9/0017 ,  A61F9/00781 ,  A61K31/407 ,  A61K31/5575 ,  A61K31/728 ,  A61N5/0601

Abstract: A glaucoma treatment system includes: a cannula body configured to be positioned in an area of Schlemm's canal; an illumination guide extending along the cannula body; at least one drug source coupled to the cannula body; a cross-linking agent source coupled to the cannula body; and an illumination source coupled to the illumination guide. The at least one drug source includes a drug that promotes outflow of aqueous humor through the trabecular meshwork and into Schlemm's canal. The cannula body delivers the drug from the at least one drug source to the area of Schlemm's canal, and in response to changes in the outflow of aqueous humor, delivers the cross-linking agent to the area of Schlemm's canal. The illumination guide delivers photo-activating light from the illumination source to the area of Schlemm's canal. The photo-activating light activates the cross-linking agent, thereby stabilizing changes in the area of Schlemm's canal.

Abstract translation: 青光眼治疗系统包括：套管主体，其被配置为定位在施莱姆氏管的一个区域中; 沿着套管主体延伸的照明引导件; 至少一个药物源，其耦合到所述套管主体; 耦合到套管本体的交联剂源; 以及耦合到照明引导件的照明源。 至少一种药物源包括促进房水通过小梁网流出并进入施莱姆氏管的药物。 套管体将药物从至少一种药物源递送到施莱姆氏管的区域，并且响应房水流出物的变化，将交联剂递送到施莱姆氏管的区域。 照明指示器将照明源的光激活光传递到施莱姆运河的区域。 光激活光激活交联剂，从而稳定了施莱姆氏管区域的变化。

公开(公告)号：US20130085370A1

公开(公告)日：2013-04-04

申请号：US13633778

申请日：2012-10-02

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Evan Sherr ,  David Muller

IPC: A61B3/16 ,  A61B3/107 ,  A61B6/00 ,  A61B3/10 ,  A61M37/00

CPC classification number: A61F9/0079 ,  A61B3/1015 ,  A61B3/102 ,  A61B3/135 ,  A61B3/16 ,  A61B8/10 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00872

Abstract: In systems and methods for generating cross-linking activity in an eye, a feedback system monitors a biomechanical strength of the eye in response to the photoactivation of a cross-linking agent applied to an eye. The feedback system includes a perturbation system that applies a force to the eye and a characterization system that determines an effect of the force on the eye. The effect of the force provides an indicator of the biomechanical strength of the eye. The characterization system determines the effect of the force on the eye by measuring an amount of deformation caused by the force or a rate of recovery from the deformation.

Abstract translation: 在用于在眼睛中产生交联活性的系统和方法中，反馈系统响应于施加到眼睛的交联剂的光活化而监测眼睛的生物力学强度。 反馈系统包括对眼睛施加力的扰动系统和确定力对眼睛的影响的表征系统。 力的作用提供了眼睛生物力学强度的指标。 表征系统通过测量由力引起的变形量或从变形恢复的速率来确定力对眼睛的影响。