公开(公告)号：US07818547B2

公开(公告)日：2010-10-19

申请号：US12106184

申请日：2008-04-18

Applicant: Tor M. Aamodt ,  Hong Wang ,  Per Hammarlund ,  John P. Shen ,  Steve Shih-wei Liao ,  Perry H. Wang

Inventor： Tor M. Aamodt ,  Hong Wang ,  Per Hammarlund ,  John P. Shen ,  Steve Shih-wei Liao ,  Perry H. Wang

IPC: G06F9/38

CPC classification number: G06F9/3842 ,  G06F9/30101 ,  G06F9/3802 ,  G06F9/383 ,  G06F9/3836 ,  G06F9/384 ,  G06F9/3851 ,  G06F9/3857 ,  G06F9/3859

Abstract: Embodiments of an apparatus, system and method enhance the efficiency of processor resource utilization during instruction prefetching via one or more speculative threads. Renamer logic and a map table are utilized to perform filtering of instructions in a speculative thread instruction stream. The map table includes a yes-a-thing bit to indicate whether the associated physical register's content reflects the value that would be computed by the main thread. A thread progress beacon table is utilized to track relative progress of a main thread and a speculative helper thread. Based upon information in the thread progress beacon table, the main thread may effect termination of a helper thread that is not likely to provide a performance benefit for the main thread.

Abstract translation: 装置，系统和方法的实施例通过一个或多个推测性线程增强在指令预取期间处理器资源利用的效率。 利用重命名逻辑和映射表来对推测性线程指令流中的指令进行滤波。 映射表包括一个肯定事件位，用于指示相关联的物理寄存器的内容是否反映由主线程计算的值。 线程进度信标表用于跟踪主线程和推测式辅助线程的相对进度。 基于线程进度信标表中的信息，主线程可能会影响不太可能为主线程提供性能优势的辅助线程的终止。

公开(公告)号：US07810083B2

公开(公告)日：2010-10-05

申请号：US11026597

申请日：2004-12-30

Applicant: Gautham N. Chinya ,  Hong Wang ,  Xiang Zou ,  James Paul Held ,  Prashant Sethi ,  Trung Diep ,  Anil Aggarwal ,  Baiju V. Patel ,  Shiv Kaushik ,  Bryant Bigbee ,  John Shen ,  Richard A. Hankins ,  John L. Reid

Inventor： Gautham N. Chinya ,  Hong Wang ,  Xiang Zou ,  James Paul Held ,  Prashant Sethi ,  Trung Diep ,  Anil Aggarwal ,  Baiju V. Patel ,  Shiv Kaushik ,  Bryant Bigbee ,  John Shen ,  Richard A. Hankins ,  John L. Reid

IPC: G06F9/45 ,  G06F9/40 ,  G06F7/38 ,  G06F9/46

CPC classification number: G06F9/45533 ,  G06F9/4881

Abstract: Method, apparatus and system embodiments to provide user-level creation, control and synchronization of OS-invisible “shreds” of execution via an abstraction layer for a system that includes one or more sequencers that are sequestered from operating system control. For at least one embodiment, the abstraction layer provides sequestration logic, proxy execution logic, transition detection and shred suspension logic, and sequencer arithmetic logic. Other embodiments are also described and claimed.

Abstract translation: 方法，装置和系统实施例，用于通过用于包括从操作系统控制隔离的一个或多个定序器的系统的抽象层来提供用户级别创建，控制和同步OS不可见的“碎片”。 对于至少一个实施例，抽象层提供封存逻辑，代理执行逻辑，转换检测和分片挂起逻辑以及定序器算术逻辑。 还描述和要求保护其他实施例。

公开(公告)号：US20100159513A1

公开(公告)日：2010-06-24

申请号：US12619790

申请日：2009-11-17

Applicant: Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang ,  Jianzhong Zhang

Inventor： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang ,  Jianzhong Zhang

IPC: C12P21/00 ,  C12N1/21

CPC classification number: C12P21/02

Abstract: Several endogenous genes have been identified in Escherichia coli, the overexpression of which increases recombinant peptide production. Increasing the copy number of aroB, aroK, proB, or crl increases the amount of a recombinant peptide produced by a host cell. Recombinant host cells comprising at least one chimeric genetic construct encoding a peptide of interest and at least one genetic modification that increases recombinant peptide production are provided as well as methods of using such recombinant host cells

Abstract translation: 已经在大肠杆菌中鉴定了几种内源基因，其过表达增加了重组肽的产生。 增加aroB，aroK，proB或crl的拷贝数增加了由宿主细胞产生的重组肽的量。 提供了包含至少一种编码目的肽的嵌合基因构建体和至少一种提高重组肽产生的遗传修饰的重组宿主细胞以及使用这种重组宿主细胞的方法

公开(公告)号：US07709601B2

公开(公告)日：2010-05-04

申请号：US11607723

申请日：2006-12-01

Applicant: Scott D. Cunningham ,  David J. Lowe ,  John P. O'Brien ,  Hong Wang ,  Antoinette E. Wilkins

Inventor： Scott D. Cunningham ,  David J. Lowe ,  John P. O'Brien ,  Hong Wang ,  Antoinette E. Wilkins

IPC: A61K38/00 ,  A61K8/64 ,  A61K8/73 ,  C12P21/06 ,  C08G63/91 ,  C40B30/06 ,  C40B40/10

CPC classification number: C07K14/001 ,  C07K7/06 ,  C07K7/08 ,  C07K17/06

Abstract: Combinatorially generated peptides are provided that have binding affinity for nylon (NY). The peptides may be used to deliver benefit agents to various NY surfaces.

Abstract translation: 提供与尼龙（NY）具有结合亲和力的组合产生的肽。 肽可以用于将有益剂递送到各种NY表面。

公开(公告)号：US07662587B1

公开(公告)日：2010-02-16

申请号：US12398358

申请日：2009-03-05

Applicant: Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang

Inventor： Qiong Cheng ,  Kevin Michael Croker ,  Kristin Ruebling-Jass ,  Hong Wang

IPC: C12P21/06 ,  C12P21/04 ,  C12P1/00 ,  C12N15/74

CPC classification number: C12N15/70 ,  C07K14/245 ,  C07K2319/00 ,  C07K2319/50

Abstract: Disrupting the expression of endogenous Escherichia host cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production relative to control Escherichia host cells. Recombinant Escherichia host cells are provided as well as methods of using such host cells for heterologous peptide production.

Abstract translation: 破坏内源性大肠杆菌宿主细胞基因gcvA和spr的表达提供相对于对照大肠杆菌宿主细胞具有增加的异源肽产生的突变宿主细胞。 提供重组埃希氏杆菌宿主细胞以及使用这种宿主细胞进行异源肽生产的方法。

公开(公告)号：US07610448B2

公开(公告)日：2009-10-27

申请号：US11646642

申请日：2006-12-27

Applicant: Mark Buxton ,  Ernie Brickell ,  Quinn A. Jacobson ,  Hong Wang ,  Baiju Patel

Inventor： Mark Buxton ,  Ernie Brickell ,  Quinn A. Jacobson ,  Hong Wang ,  Baiju Patel

IPC: G06F12/00 ,  G06F13/00 ,  G06F13/28 ,  G06F12/14 ,  G06F11/00 ,  G06F12/16 ,  G06F15/18 ,  G08B23/00

CPC classification number: G06F12/0842 ,  G06F9/30047 ,  G06F12/1458 ,  G06F21/52 ,  G06F21/78

Abstract: For each memory location in a set of memory locations associated with a thread, setting an indication associated with the memory location to request a signal if data from the memory location is evicted from a cache; and in response to the signal, reloading the set of memory locations into the cache.

Abstract translation: 对于与线程相关联的一组存储器位置中的每个存储器位置，设置与存储器位置相关联的指示，以便如果来自存储器位置的数据被从高速缓存中移出，则请求信号; 并且响应于该信号，将该组存储器位置重新加载到高速缓存中。

公开(公告)号：US07603546B2

公开(公告)日：2009-10-13

申请号：US10950693

申请日：2004-09-28

Applicant: Satish Narayanasamy ,  Hong Wang ,  John Shen ,  Roni Rosner ,  Yoav Almog ,  Naftali Schwartz ,  Gerolf Hoflehner ,  Daniel LaVery ,  Wei Li ,  Xinmin Tian ,  Milind Girkar ,  Perry Wang

Inventor： Satish Narayanasamy ,  Hong Wang ,  John Shen ,  Roni Rosner ,  Yoav Almog ,  Naftali Schwartz ,  Gerolf Hoflehner ,  Daniel LaVery ,  Wei Li ,  Xinmin Tian ,  Milind Girkar ,  Perry Wang

IPC: G06F9/00 ,  G06F9/24 ,  G06F15/177

CPC classification number: G06F8/443 ,  G06F8/433 ,  G06F8/451

Abstract: Embodiments of the present invention provide a method, apparatus and system which may include splitting a dependency chain into a set of reduced-width dependency chains; mapping one or more dependency chains onto one or more clustered dependency chain processors, wherein an issue-width of one or more of the clusters is adapted to accommodate a size of the dependency chains; and/or processing in parallel a plurality of dependency chains of a trace. Other embodiments are described and claimed.

Abstract translation: 本发明的实施例提供了一种方法，装置和系统，其可以包括将依赖链分解成一组缩减宽度的依赖性链; 将一个或多个依赖关系链映射到一个或多个聚类依赖链处理器上，其中一个或多个所述簇的问题宽度适于适应所述依赖链的大小; 和/或并行处理多个跟踪的依赖性链。 描述和要求保护其他实施例。

公开(公告)号：US20090158248A1

公开(公告)日：2009-06-18

申请号：US11958307

申请日：2007-12-17

Applicant: Michael D. Linderman ,  Jamison D. Collins ,  Perry Wang ,  Hong Wang

Inventor： Michael D. Linderman ,  Jamison D. Collins ,  Perry Wang ,  Hong Wang

IPC: G06F9/44

CPC classification number: G06F9/505 ,  G06F2209/5017

Abstract: Presented are embodiments of methods and systems for library-based compilation and dispatch to automatically spread computations of a program across heterogeneous cores in a processing system. The source program contains a parallel-programming keyword, such as mapreduce, from a high-level, library-oriented parallel programming language. The compiler inserts one or more calls for a generic function, associated with the parallel-programming keyword, into the compiled code. A runtime library provides a predicate-based library system that includes multiple hardware specific implementations (“variants”) of the generic function. A runtime dispatch engine dynamically selects the best-available (e.g., most specific) variant, from a bundle of hardware-specific variants, for a given input and machine configuration. That is, the dispatch engine may take into account run-time availability of processing elements, choose one of them, and then select for dispatch an appropriate variant to be executed on the selected processing element. Other embodiments are also described and claimed.

Abstract translation: 提出了用于基于库的编译和调度的方法和系统的实施例，以便在处理系统中跨异构核心自动扩展程序的计算。 源程序包含一个并行编程关键字，如mapreduce，来自高级的面向库的并行编程语言。 编译器将一个或多个与并行编程关键字关联的通用函数的调用插入到编译代码中。 运行时库提供了一个基于谓词的库系统，它包含通用函数的多个硬件特定实现（“变体”）。 对于给定的输入和机器配置，运行时调度引擎从一组特定于硬件的变体动态地选择最佳可用（例如，最具体的）变体。 也就是说，调度引擎可以考虑处理元件的运行时间可用性，选择其中之一，然后选择在所选择的处理元件上调度要执行的适当变体。 还描述和要求保护其他实施例。

公开(公告)号：US20090143295A1

公开(公告)日：2009-06-04

申请号：US12273778

申请日：2008-11-19

Applicant: JOHN P. O'BRIEN ,  Hong Wang ,  Antoinette E. Wilkins

Inventor： JOHN P. O'BRIEN ,  Hong Wang ,  Antoinette E. Wilkins

IPC: A61K47/48 ,  A61K31/60 ,  A61K31/085 ,  A61K38/00 ,  A61K38/10 ,  A61K38/08 ,  A61P17/10

CPC classification number: C07K14/463 ,  A61K31/085 ,  A61K31/60 ,  A61K47/64 ,  C07K7/06 ,  C07K7/08 ,  C07K2319/01

Abstract: Peptide-based antiacne reagents, formed by coupling a skin-binding peptide with an antiacne agent, are described. The skin-binding peptide portion of the peptide-based antiacne reagent binds strongly to the skin, thus keeping the antiacne agent coupled to the skin for a long lasting effect. Skin care compositions comprising the peptide-based antiacne reagents are also provided as well as a method of treating or preventing skin acne.

Abstract translation: 描述了通过将皮肤结合肽与抗痤疮剂偶联而形成的基于肽的抗痤疮试剂。 基于肽的抗痤疮剂的皮肤结合肽部分强烈地与皮肤结合，从而保持抗皮肤剂与皮肤偶联以获得持久的效果。 还提供了包含基于肽的抗痤疮试剂的护肤组合物以及治疗或预防皮肤痤疮的方法。

公开(公告)号：US20090123456A1

公开(公告)日：2009-05-14

申请号：US11724605

申请日：2007-03-15

Applicant: Kevin J. Tracey ,  Hong Wang

Inventor： Kevin J. Tracey ,  Hong Wang

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/53 ,  C12Q1/68 ,  A61K31/715

CPC classification number: A61K31/46 ,  A61K31/00 ,  A61K31/439 ,  A61K31/444 ,  G01N33/6863 ,  G01N33/9406 ,  G01N2333/525 ,  G01N2333/54 ,  Y02A50/385 ,  Y02A50/411

Abstract: A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein.

Abstract translation: 一种治疗患有胰腺炎的患者的方法，其包括以足以减少从巨噬细胞释放的促炎细胞因子的量的治疗有效量的对α7烟碱受体选择性的胆碱能激动剂治疗所述患者，其中所述病症是 急性胰腺炎。 本发明的化合物包括可卡因的四元类似物; （1-氮杂 - 双环[2.2.2]辛-3-基） - 氨基甲酸1-（2-氟苯基） - 乙酯; 式（I）化合物，式（II）化合物，式（III）化合物，式（IV）化合物和能够减弱急性胰腺炎症状的寡核苷酸或模拟物，其中寡核苷酸或模拟物 基本上由大于5个核苷酸长的序列组成，其与α7胆碱能受体的mRNA互补。 本文描述了式（I），（II），（III）和（IV）的变量。