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公开(公告)号：US09594039B2
公开(公告)日：2017-03-14
申请号：US14583239
申请日：2014-12-26
Applicant: Palo Alto Research Center Incorporated
Inventor： Michael I. Recht , Joerg Martini , Gregory L. Whiting , Francisco E. Torres
CPC classification number: G01N25/482 , G01N21/00 , G01N25/20
Abstract: A method for detecting an enthalpy change includes providing a first mixture and a second mixture to a drop generator. The first mixture includes a ligand. The second mixture contains a target molecule. The method further includes generating a drop in the drop generator. The drop includes the target molecule, a temperature-sensitive reporter compound, and the ligand. The method also includes measuring a property of the temperature-sensitive reporter compound in the drop to determine an amount of enthalpy change that has occurred.
Abstract translation: 用于检测焓变的方法包括向液滴发生器提供第一混合物和第二混合物。 第一混合物包括配体。 第二混合物含有靶分子。 该方法还包括在液滴发生器中产生液滴。 该滴包括靶分子，温度敏感的报导物化合物和配体。 该方法还包括测量滴液中温度敏感性报告化合物的性质，以确定发生的焓变量。
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公开(公告)号：US09400174B2
公开(公告)日：2016-07-26
申请号：US14246912
申请日：2014-04-07
Applicant: Palo Alto Research Center Incorporated
Inventor： Peter Kiesel , Joerg Martini , Eugene M. Chow , Scott Uhland , Noble M. Johnson
CPC classification number: A61M5/3015 , A61M5/2053 , A61M2205/3306 , A61M2210/04 , G01B11/14 , G01N15/00 , G01N15/1434 , G01N2015/0003 , G01N2015/0046 , G01N2015/1075 , G01N2015/1087 , G01N2015/1093
Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.
Abstract translation: 公开了确定颗粒如药物颗粒的递送成功的方法。 用于监测颗粒递送到生物组织的系统包括体积，光学部件，检测器和分析器。 该体积包括颗粒可以通过其沿所需方向通过的空间。 光学部件被配置成提供测量光。 检测器被定位成响应于测量光来检测从颗粒发出的光。 随着粒子沿着检测轴移动，被检测的光被调制。 检测器被配置为响应于检测到的光而产生时变信号。 分析器被配置为接收时变信号，并且基于时变信号的特性来确定颗粒进入生物组织的递送成功。
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公开(公告)号：US20150105295A1
公开(公告)日：2015-04-16
申请号：US14576156
申请日：2014-12-18
Applicant: Palo Alto Research Center Incorporated
Inventor： Peter Kiesel , Joerg Martini , Michael I. Recht
IPC: G01N21/64 , G01N33/58 , G01N33/543 , B01J19/00
CPC classification number: G01N21/6428 , B01J19/0046 , B01J2219/00545 , B01J2219/00576 , B01J2219/00587 , B01J2219/00596 , G01N21/6452 , G01N33/542 , G01N33/54313 , G01N33/582 , G01N33/583 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
Abstract: Analysis of a system and/or sample involves the use of absorption-encoded micro beads. Each type of micro bead is encoded with amounts of the k dyes in a proportional relationship that is different from proportional relationships of the k dyes of others of the n types of absorption-encoded micro beads. A system and/or a sample can be analyzed using information obtained from detecting the one or more types of absorption-encoded micro beads.
Abstract translation: 系统和/或样品的分析涉及使用吸收编码的微珠。 每种类型的微珠以与n种类型的吸收编码微珠的其它染料的比例关系不同的比例关系用k个染料的量进行编码。 可以使用从检测一种或多种类型的吸收编码的微珠获得的信息来分析系统和/或样品。
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54.发明授权公开(公告)号：US11984701B2
公开(公告)日：2024-05-14
申请号：US17408745
申请日：2021-08-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Sourobh Raychaudhuri , Christopher Chua , David K. Biegelsen , Joseph Lee
CPC classification number: H01S5/04256 , B41J2/442 , B41J2/45 , B41J2/455 , H01S5/042 , H01S5/4025 , H01S5/423
Abstract: A computer adapted to convert images into raw data can provide the raw data to a control interface adapted to transmit the raw data with timing information to an electronic driver circuit. The electronic driver circuit can convert the raw data with the timing information provided by a control interface into regulated current signals provided to the semiconductor laser array at 300 dpi and higher. The semiconductor array can convert the current signals into light to illuminate an imaging member. The laser array can comprise vertical cavity surface emitting lasers providing imaging greater than 300 dpi. Each semiconductor laser can operate at 50 mW or greater.
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公开(公告)号：US11827037B2
公开(公告)日：2023-11-28
申请号：US17408814
申请日：2021-08-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Christopher Chua , Zhihong Yang , Mark Teepe , Patrick Y. Maeda , Sourobh Raychaudhuri , Elif Karatay , Noble M. Johnson , David K. Biegelsen , Joseph Lee
IPC: H01S5/042 , H01S5/40 , H01S5/42 , H01S5/183 , B41J2/44 , B41J2/45 , B41J2/455 , B41J2/47 , G02B19/00
CPC classification number: B41J2/455 , B41J2/442 , B41J2/47 , G02B19/0014 , G02B19/0057 , H01S5/042 , H01S5/18394 , H01S5/4025 , H01S5/423
Abstract: A laser imager for a printing system, comprising a plurality of independently addressable surface emitting lasers arranged in a linear array on a common substrate chip and including a common cathode and a dedicated control channel associated with an address trace line for each laser of the plurality of independently addressable surface emitting lasers, and optical elements arranged in a linear lens array configured to capture and focus light from the plurality of independently addressable surface emitting lasers onto a imaging member, wherein the plurality of independently addressable surface emitting lasers arranged in a linear array and the optical elements arranged in a linear lens array operate together to image the imaging member.
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Patent Agency Ranking
公开(公告)号：US20230056416A1
公开(公告)日：2023-02-23
申请号：US17408762
申请日：2021-08-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Christopher Chua , Joerg Martini , Mark Teepe , Elif Karatay
IPC: H01S5/42 , H01S5/183 , H01S5/02355
Abstract: A method of transferring a semiconductor epi layer onto a metal host substrate is described. An epi layer of a semiconductor chip (e.g., semiconductor laser array) including a substrate can be mounted onto a planar handle wafer with an adhesive, wherein a backside of the substrate faces upward and away from the epi layer and the planar handle wafer. The backside of the substrate can be treated to substantially remove the substrate, while leaving the epi layer undamaged (e.g., by polishing to where no more than 20 micrometers of the substrate remains). Metal can be formed on the treated backside resulting in a metalized backside. The planar handle wafer can then be removed from the epi layer by dissolving the adhesive with a solvent, wherein a modified semiconductor chip remains. The semiconductor chip can be annealed to form a backside ohmic contact interface. The semiconductor chip can then be attached to a mechanical block by the ohmic contact interface.
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公开(公告)号：US20230055149A1
公开(公告)日：2023-02-23
申请号：US17408814
申请日：2021-08-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Christopher Chua , Zhihong Yang , Mark Teepe , Patrick Y. Maeda , Sourobh Raychaudhuri , Elif Karatay , Noble M. Johnson , David K. Biegelsen , Joseph Lee
Abstract: A laser imager for a printing system, comprising a plurality of independently addressable surface emitting lasers arranged in a linear array on a common substrate chip and including a common cathode and a dedicated control channel associated with an address trace line for each laser of the plurality of independently addressable surface emitting lasers, and optical elements arranged in a linear lens array configured to capture and focus light from the plurality of independently addressable surface emitting lasers onto a imaging member, wherein the plurality of independently addressable surface emitting lasers arranged in a linear array and the optical elements arranged in a linear lens array operate together to image the imaging member.
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公开(公告)号：US20230046089A1
公开(公告)日：2023-02-16
申请号：US17402067
申请日：2021-08-13
Applicant: Palo Alto Research Center Incorporated
Inventor： Jacob Chamoun , Michael I. Recht , Joerg Martini , Anne Plochowietz
IPC: G01K11/12
Abstract: Methods and systems for measuring the temperature of a sample can include the use of one or more illumination sources and a sample containing thermochromic material. One or more detectors are operable to detect two or more signals indicative of a component of an illumination facilitated by the illumination source(s) and scattered at two or more angles with respect to the sample containing the thermochromic material, wherein the signals are converted to a temperature.
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公开(公告)号：US11493451B2
公开(公告)日：2022-11-08
申请号：US16724644
申请日：2019-12-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Gabriel Iftime , Stephen Matthew Meckler , David Eric Schwartz , Joerg Martini , Jessica Louis Baker Rivest
Abstract: A test strip includes a substantially transparent substrate and one or more colorimetric test spots on the transparent substrate. Each colorimetric test spot has one or more sensing chemicals chemically attached onto a porous support material. The porous support material has at least one exposed surface configured to absorb a body fluid. The one or more sensing chemicals are configured to change a color in response to a presence of a target drug in the body fluid.
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公开(公告)号：US20220259545A1
公开(公告)日：2022-08-18
申请号：US17733076
申请日：2022-04-29
Applicant: Palo Alto Research Center Incorporated
Inventor： Michael I. Recht , Joerg Martini , Peter Kiesel
Abstract: A test vessel includes one or more test locations configured to contain a medium suitable for culturing a live substance. A thermochromic material is thermally coupled to the one or more test locations. The thermochromic material is configured to exhibit a spectral shift in light emanating from the thermochromic material in response to an increase or decrease in energy conversion by the live substance that causes a change in temperature of the thermochromic material.
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