公开(公告)号：US08383583B2

公开(公告)日：2013-02-26

申请号：US12257769

申请日：2008-10-24

Applicant: Joel D. Moore ,  Yat Sun Or ,  Zhe Wang

Inventor： Joel D. Moore ,  Yat Sun Or ,  Zhe Wang

IPC: A61K38/00

CPC classification number: C07D498/16 ,  A61K31/13 ,  A61K31/505 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  C07D487/16 ,  C07K5/0808 ,  A61K2300/00

Abstract: The present invention relates to compounds of Formula I, II, or III, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

Abstract translation: 本发明涉及式I，II或III的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US08357092B2

公开(公告)日：2013-01-22

申请号：US11605605

申请日：2006-11-29

Applicant: Zhaoquan Liu ,  Qianquan Han ,  Zhe Wang

Inventor： Zhaoquan Liu ,  Qianquan Han ,  Zhe Wang

IPC: A61B8/00

CPC classification number: G06F3/021 ,  A61B8/467 ,  G06F3/0219 ,  G06F3/023

Abstract: This invention discloses a medical diagnosis system a control panel thereof. According to this invention, a USB technology is utilized to perform input via the human-computer interface of the medical diagnosis system. Except for completely compatible with the standard alphanumeric keys portion, the control panel further comprises specific function modules for the medical diagnosis system and the trackball module. The connection of all function modules of the control panel are implemented by one physical interface. Universal alphanumeric keys and the trackball, as well as the specific function modules for the medical diagnostic equipment, are integrated into a whole body, and communicate with the upper computer (PC) via one physical interface, thereby complexity in connecting the peripheral devices of the human-computer interface is reduced, Plug-and-Play can be supported, and the use of it is easier and more convenient.

Abstract translation: 本发明公开了一种医疗诊断系统及其控制面板。 根据本发明，利用USB技术经由医疗诊断系统的人机界面进行输入。 除了与标准字母数字键部分完全兼容之外，控制面板还包括用于医疗诊断系统和轨迹球模块的特定功能模块。 控制面板所有功能模块的连接由一个物理接口实现。 通用字母数字键和轨迹球以及医疗诊断设备的特定功能模块集成到一个整体中，并通过一个物理接口与上位机（PC）进行通信，从而连接外部设备的复杂性 减少了人机界面，可以支持即插即用，使用起来更方便，更方便。

公开(公告)号：US08346009B2

公开(公告)日：2013-01-01

申请号：US12803370

申请日：2010-06-25

Applicant: Jiefu Zhai ,  Joan Llach ,  Zhe Wang

Inventor： Jiefu Zhai ,  Joan Llach ,  Zhe Wang

IPC: G06K9/36

CPC classification number: H04N5/202 ,  G09G3/2003 ,  G09G2340/0428 ,  G09G2340/06

Abstract: A method for tone mapping high dynamic range images for display on low dynamic range displays wherein high dynamic range images are first accessed. The high dynamic range images are divided the into different regions such that each region is represented by a matrix, where each element of the matrix is a weight or probability of a pixel value. An exposure of each region is determined or calculated by estimating an anchor point in each region such that most pixels in each region are mapped to mid grey and the anchor points are adjusted to a key of the images to preserve overall brightness. The regions are then placed or mapped to zones and exposure values are applied to the regions responsive to the weight or probability. The regions are fused together to obtain a final tone mapped image.

Abstract translation: 一种用于将高动态范围图像进行色调映射以在低动态范围显示器上显示的方法，其中首先访问高动态范围图像。 高动态范围图像被划分成不同的区域，使得每个区域由矩阵表示，其中矩阵的每个元素是像素值的权重或概率。 通过估计每个区域中的锚点来确定或计算每个区域的曝光，使得每个区域中的大多数像素被映射到中间灰色，并且将锚点调整为图像的关键以保持整体亮度。 然后将区域放置或映射到区域，并且响应于重量或概率将曝光值应用于区域。 将这些区域融合在一起以获得最终的色调映射图像。

公开(公告)号：US20120288217A1

公开(公告)日：2012-11-15

申请号：US13574919

申请日：2011-01-25

Applicant: Jiefu Zhai ,  Zhe Wang ,  Dong-Qing Zhang

Inventor： Jiefu Zhai ,  Zhe Wang ,  Dong-Qing Zhang

IPC: G06T5/50

CPC classification number: H04N5/235 ,  G06T5/50 ,  G06T2200/21 ,  G06T2207/20208 ,  H04N5/2355

Abstract: A new high dynamic range image synthesis which can handle the local object motion, wherein an interactive graphical user interface is provided for the end user, through which one can specify the source image for separate part of the final high dynamic range image, either by creating a image mask or scribble on the image. The high dynamic range image synthesis includes the following steps: capturing low dynamic range images with different exposures; registering the low dynamic range images; estimating camera response function; converting the low dynamic range images to temporary radiance images using estimated camera response function; and fusing the temporary radiance images into a single high dynamic range (HDR) image by employing a method of layered masking.

Abstract translation: 可以处理局部对象运动的新的高动态范围图像合成，其中为最终用户提供交互式图形用户界面，通过该动态范围图像可以为最终的高动态范围图像的分离部分指定源图像，通过创建 图像掩码或图像上的涂鸦。 高动态范围图像合成包括以下步骤：捕获具有不同曝光的低动态范围图像; 注册低动态范围图像; 估计摄像机响应功能; 使用估计的相机响应函数将低动态范围图像转换成临时辐射图像; 并通过采用分层掩蔽的方法将临时辐射图像融合到单个高动态范围（HDR）图像中。

公开(公告)号：US20120084085A1

公开(公告)日：2012-04-05

申请号：US13325985

申请日：2011-12-14

Applicant: Zhe Wang

Inventor： Zhe Wang

IPC: G10L15/20

CPC classification number: G10L21/0208 ,  G10L25/84

Abstract: A method and a device for tracking background noise in a communication system are provided. The method includes: calculating a SNR of a current frame according to input audio signals; increasing a frame counter, and calculating tone features and signal steadiness features of the current frame if the SNR of the current frame is not less than a first threshold; determining the possibility of a time window including a noise interval according to the calculated tone feature values and signal steadiness feature values of each frame of the time window when the frame counter is increased to the length of the time window; and extracting noise features in the time window. Existence of background noise is analyzed continuously in a time window, so that background noise that changes frequently.

Abstract translation: 提供了一种用于跟踪通信系统中的背景噪声的方法和装置。 该方法包括：根据输入的音频信号计算当前帧的SNR; 如果当前帧的SNR不小于第一阈值，则增加帧计数器，以及计算当前帧的色调特征和信号稳定特征; 当帧计数器增加到时间窗口的长度时，根据所计算的色调特征值和时间窗的每个帧的信号稳定特征值，确定包括噪声间隔的时间窗口的可能性; 并在时间窗口中提取噪声特征。 在时间窗口中连续分析背景噪声的存在，从而频繁变化的背景噪声。

公开(公告)号：US20120065966A1

公开(公告)日：2012-03-15

申请号：US13307683

申请日：2011-11-30

Applicant: Zhe Wang

Inventor： Zhe Wang

IPC: G10L21/02 ,  G10L11/02

CPC classification number: G10L25/78 ,  G10L25/09

Abstract: A voice activity detection method and apparatus, and an electronic device are provided. The method includes: obtaining a time domain parameter and a frequency domain parameter from an audio frame; obtaining a first distance between the time domain parameter and a long-term slip mean of the time domain parameter in a history background noise frame, and obtaining a second distance between the frequency domain parameter and a long-term slip mean of the frequency domain parameter in the history background noise frame; and judging whether the audio frame is a foreground voice frame or a background noise frame according to the first distance, the second distance and a set of decision inequalities based on the first distance and the second distance. The above technical solutions enable the judgment criterion to have an adaptive adjustment capability, thus improving the performance of the voice activity detection.

Abstract translation: 提供语音活动检测方法和装置以及电子装置。 该方法包括：从音频帧获得时域参数和频域参数; 在历史背景噪声帧中获得时域参数与时域参数的长期滑动平均值之间的第一距离，并获得频域参数与频域参数的长期滑动平均值之间的第二距离 在历史背景噪音框架; 以及根据所述第一距离，所述第二距离和基于所述第一距离和所述第二距离的一组判定不等式来判断所述音频帧是前景语音帧还是背景噪声帧。 上述技术方案使得判断标准具有自适应调整能力，从而提高语音活动检测的性能。

公开(公告)号：US20110238418A1

公开(公告)日：2011-09-29

申请号：US13116323

申请日：2011-05-26

Applicant: Zhe Wang

Inventor： Zhe Wang

IPC: G10L15/20

CPC classification number: G10L21/0208 ,  G10L25/84

Abstract: A method and a device for tracking background noise in a communication system, where the method includes: calculating a SNR of a current frame according to input audio signals; increasing a frame counter, and calculating tone features and signal steadiness features of the current frame if the SNR of the current frame is not smaller than a first threshold; judging the possibility of a time window including a noise interval according to the calculated tone feature values and signal steadiness feature values of each frame of the time window when the frame counter is increased to the length of the time window; and extracting noise features in the time window. Existence of background noise is analyzed continuously in a time window, so that background noise that changes frequently and dramatically can be detected or tracked rapidly.

Abstract translation: 一种在通信系统中跟踪背景噪声的方法和装置，其中该方法包括：根据输入的音频信号计算当前帧的SNR; 增加帧计数器，并且如果当前帧的SNR不小于第一阈值，则计算当前帧的色调特征和信号稳定特征; 当帧计数器增加到时间窗口的长度时，根据所计算的色调特征值和时间窗口的每个帧的信号稳定特征值来判断包括噪声间隔的时间窗口的可能性; 并在时间窗口中提取噪声特征。 在时间窗口中连续分析背景噪声的存在，从而可以快速检测或跟踪快速变化的背景噪声。

公开(公告)号：US07919627B2

公开(公告)日：2011-04-05

申请号：US12135299

申请日：2008-06-09

Applicant: Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

Inventor： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D401/14

Abstract: The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

Abstract translation: 本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

公开(公告)号：US07662779B2

公开(公告)日：2010-02-16

申请号：US11835657

申请日：2007-08-08

Applicant: Ying Sun ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

Inventor： Ying Sun ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

IPC: A61K38/12 ,  C07K5/12

CPC classification number: C07D487/04 ,  A61K31/4192 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07D471/04 ,  A61K2300/00

Abstract: The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.

Abstract translation: 本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过向受试者施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US20090304629A1

公开(公告)日：2009-12-10

申请号：US12351144

申请日：2009-01-09

Applicant: Zhenwei Miao ,  Ying Sun ,  Suanne Nakajima ,  Datong Tang ,  Frank Wu ,  Guoyou Xu ,  Yat S. Or ,  Zhe Wang

Inventor： Zhenwei Miao ,  Ying Sun ,  Suanne Nakajima ,  Datong Tang ,  Frank Wu ,  Guoyou Xu ,  Yat S. Or ,  Zhe Wang

IPC: A61K38/06 ,  C07D487/04 ,  A61K38/05 ,  C07K5/083 ,  A61P31/12 ,  A61K38/21 ,  A61K33/08

CPC classification number: C07D487/04 ,  A61K38/12 ,  C07K5/0806 ,  E05F15/73 ,  E05F2015/763

Abstract: The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract translation: 本发明涉及式I，II或III的化合物或其药学上可接受的盐，酯或前药：其中W是取代或未取代的杂环体系。 该化合物抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。