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公开(公告)号：US20240278012A1
公开(公告)日：2024-08-22
申请号：US18653888
申请日：2024-05-02
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC classification number: A61N1/36014 , A61N1/0456 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
Abstract: Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.
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公开(公告)号：US20240170162A1
公开(公告)日：2024-05-23
申请号：US18392098
申请日：2023-12-21
Applicant: ElectroCore, Inc.
Inventor： Peter Staats , Thomas Errico , Joseph P. Errico , Bruce J. Simon
CPC classification number: G16H50/80 , A61N1/36 , A61N1/36034 , A61N1/36053 , G16B35/00 , G16H70/60
Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
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公开(公告)号：US20240139508A1
公开(公告)日：2024-05-02
申请号：US18405000
申请日：2024-01-05
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC classification number: A61N1/36025 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02 , A61N1/36114
Abstract: Methods and devices are provided for the non-invasive treatment of diseases or disorders, such as Alzheimer's disease, Parkinson's disease, rheumatoid arthritis (RA), multiple sclerosis, postoperative cognitive dysfunction, or postoperative delirium. A method for comprises positioning an electrode in contact with an outer skin surface of a neck of the patient and transmitting, via the electrode, an electric current transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient. The electrical impulse comprises bursts of 2 to 20 pulses with each of the bursts comprising a frequency from about 15 Hz to about 50 Hz and with each of the pulses comprising a duration from about 20 microseconds to about 1000 microseconds.
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公开(公告)号：US20240050733A1
公开(公告)日：2024-02-15
申请号：US18492739
申请日：2023-10-23
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
CPC classification number: A61N1/0456 , A61N1/36034 , A61N1/36053 , A61N1/40 , A61M2021/0022
Abstract: Systems and methods are provided for delivering energy impulses (and/or fields) to bodily tissues. In certain aspects, the systems and methods are particularly useful for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings. In certain embodiments, the methods and devices enhance neurostructural development over a period of time by increasing neurogenesis, neuronal plasticity and/or neural connectivity efficiency, and/or by improving the chemical microenvironment of the evolving neural network. In some embodiments, these enhancements may provide temporary improvement to enable an individual to, for example, accomplish a particular task while under duress, sleep deprivation, stress, anxiety or the like. In other embodiments, these changes permanently enhance the intelligence, emotional stability, and overall brain health of the treated individual.
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公开(公告)号：US20230381507A1
公开(公告)日：2023-11-30
申请号：US18201800
申请日：2023-05-25
Applicant: ELECTROCORE, INC
Inventor： Joseph P. Errico , Steven Mendez , Bruce J. Simon
CPC classification number: A61N1/36021 , A61N1/36025 , H04M1/21 , A61N1/0456 , A61N1/3603 , A61N1/36034 , A61N1/37217 , A61N1/3756 , A61N1/3787 , A61B5/6898
Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the trigeminal nerve. A system comprises one or more electrodes configured for contacting an outer skin surface of a patient and a stimulator coupled to the one or more electrodes. The stimulator is configured to transmit an electrical impulse from the electrodes through the outer skin surface to a target site within a patient. A software application coupled to the stimulator. The software application may, for example, be downloadable onto a mobile device and may allow the user to transmit data to and from the stimulator and/or control operation of the stimulator.
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Patent Agency Ranking
公开(公告)号：US20230381499A1
公开(公告)日：2023-11-30
申请号：US18228918
申请日：2023-08-01
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
CPC classification number: A61N1/0551 , A61N1/36025 , A61N1/0456 , A61N2/006 , A61N1/36021 , A61N1/00 , A61N1/36014 , A61N2/02
Abstract: Devices, systems and methods are disclosed for electrical stimulation of nerves to treat one or more symptoms in a user. The methods comprise transcutaneously transmitting electrical impulses to the nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session of 2 to 4 times within an hour time period and/or as a single dose from 2 to 5 times during a day.
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公开(公告)号：US11623080B2
公开(公告)日：2023-04-11
申请号：US17702051
申请日：2022-03-23
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US11623079B2
公开(公告)日：2023-04-11
申请号：US17461886
申请日：2021-08-30
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US11623078B2
公开(公告)日：2023-04-11
申请号：US17072392
申请日：2020-10-16
Applicant: ELECTROCORE, INC.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses.
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公开(公告)号：US20230005626A1
公开(公告)日：2023-01-05
申请号：US17944131
申请日：2022-09-13
Applicant: ELECTROCORE, INC
Inventor： Joseph P. Errico , Bruce J. Simon , Peter Staats , Thomas Errico
Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
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