公开(公告)号：US20160107395A1

公开(公告)日：2016-04-21

申请号：US14985226

申请日：2015-12-30

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S.D. Lee ,  David Lee Safranski

IPC: B29C67/20

CPC classification number: B29C43/04 ,  B29C33/00 ,  B29C44/58 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7532 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2300/22 ,  C08J2371/00

Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.

公开(公告)号：US20150374477A1

公开(公告)日：2015-12-31

申请号：US14752762

申请日：2015-06-26

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang CHANG ,  Stephen Lee LAFFOON ,  Christopher S.D. LEE ,  David Lee SAFRANSKI

IPC: A61F2/00 ,  A61B19/00 ,  B29C67/20 ,  A61L31/06

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将固体聚合物片的表面加热至加工温度并保持加工温度，同时使致孔剂层通过聚合物的表面移位，以形成包含聚合物的固体聚合物主体的基质层，以及 致孔剂层。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。

公开(公告)号：US20120323339A1

公开(公告)日：2012-12-20

申请号：US13518669

申请日：2010-12-23

Applicant: Beatriz Olalde Graells ,  María Jesús Jurado Oñate

Inventor： Beatriz Olalde Graells ,  María Jesús Jurado Oñate

IPC: A61L27/56 ,  B29C67/20 ,  C08J9/28 ,  B32B5/18 ,  A61F2/28

CPC classification number: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2201/0446 ,  C08J2201/052 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249986 ,  C08L71/00

Abstract: The present invention refers to a porous PEEK-type polymer article comprising a porous PEEK-type polymer structure and presenting at least a trimodal pore distribution. The invention describes a process for the production of said porous PEEK-type polymer article comprising: a) contacting a PEEK-type polymer with a composition comprising at least a organic solvent, b) heating at a temperature at which the PEEK-type polymer is dissolved, c) adding at least a porogen agent, d) cooling the mixture obtained in c) at a temperature at least equal or lower than the temperature at which the PEEK-type polymer precipitates, e) forming said cooled mixture into a shaped article, f) removing the organic solvent and the porogen agent, and g) recovering the PEEK-type polymer article.

Abstract translation: 本发明涉及包含多孔PEEK型聚合物结构并呈现至少三峰孔分布的多孔PEEK型聚合物制品。 本发明描述了一种生产所述多孔PEEK型聚合物制品的方法，包括：a）使PEEK型聚合物与至少包含有机溶剂的组合物接触，b）在PEEK型聚合物为 溶解，c）至少加入致孔剂，d）在至少等于或低于PEEK型聚合物沉淀的温度的温度下冷却c）中得到的混合物，e）将所述冷却的混合物形成成型制品 ，f）除去有机溶剂和致孔剂，g）回收PEEK型聚合物制品。

公开(公告)号：US20110212179A1

公开(公告)日：2011-09-01

申请号：US13126456

申请日：2009-10-30

Applicant: David Liu

Inventor： David Liu

IPC: A61K9/14 ,  A61K35/00 ,  A61K35/12 ,  C12N5/071 ,  B01J19/00 ,  C08G63/91 ,  C08F20/56 ,  C08F116/06 ,  C08J9/00 ,  C08G73/10 ,  B82Y30/00

CPC classification number: C08J9/26 ,  A61K9/0019 ,  A61K9/5031 ,  A61K9/5089 ,  A61K48/00 ,  A61K51/1255 ,  A61L24/0036 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/56 ,  A61L2430/36 ,  C08J9/28 ,  C08J2201/0446 ,  C08J2201/0544 ,  C08J2207/10 ,  C12N15/88

Abstract: Provided herein are bimodal porous polymer microspheres comprising macropores and micropores. Also provided herein are methods and apparatus for fabrication such microspheres. Further provided herein are methods of using bimodal porous polymer microspheres.

Abstract translation: 本文提供了包含大孔和微孔的双峰多孔聚合物微球。 本文还提供了用于制造这种微球的方法和装置。 本文还提供了使用双峰多孔聚合物微球的方法。

公开(公告)号：US20110105635A1

公开(公告)日：2011-05-05

申请号：US12993774

申请日：2009-05-19

Applicant: Folkert Van Beijma ,  Jacqueline De Groot

Inventor： Folkert Van Beijma ,  Jacqueline De Groot

IPC: C08G18/02 ,  C08G18/10 ,  C08J9/26

CPC classification number: C08G18/10 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  C08G18/4277 ,  C08G18/73 ,  C08G18/82 ,  C08G2101/00 ,  C08G2230/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2375/04 ,  C08L75/04 ,  C08G18/3206

Abstract: The present invention provides a polyurethane implant that is porous and degradable, and act as a scaffold for the repair of damaged tissue. Importantly, the implant of the present invention is biocompatible with the degradation products of the implant causing minimal immune or cytotoxic reaction. The present invention also provides for a method of making these biocompatible implants.

Abstract translation: 本发明提供一种多孔和可降解的聚氨酯植入物，并且用作修复受损组织的支架。 重要的是，本发明的植入物与植入物的降解产物是生物相容的，导致最小的免疫或细胞毒性反应。 本发明还提供了制造这些生物相容植入物的方法。

公开(公告)号：US07816461B2

公开(公告)日：2010-10-19

申请号：US11718962

申请日：2005-11-18

Applicant: Shanfeng Wang ,  Michael J. Yaszemski ,  Lichun Lu ,  Bradford L. Currier

Inventor： Shanfeng Wang ,  Michael J. Yaszemski ,  Lichun Lu ,  Bradford L. Currier

IPC: C08G63/91

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

Abstract translation: 聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（己内酯）的嵌段共聚物。 聚（丙烯酸富马酸酯）和聚（己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。 因此，共聚物既可自交联（不使用任何交联剂）和光可交联（在诸如紫外光的光子存在下）。

公开(公告)号：US20090222091A1

公开(公告)日：2009-09-03

申请号：US12092487

申请日：2006-11-06

Applicant: Daniel Morrissette ,  Patrick Croteau

Inventor： Daniel Morrissette ,  Patrick Croteau

IPC: C08J9/24 ,  B29C44/04 ,  A61F2/44 ,  A61L31/04

CPC classification number: B32B5/145 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  B32B5/22 ,  B32B27/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249991 ,  C08L71/00

Abstract: A method for fabricating a porous structure from a first material. The method comprises the acts of mixing the first material with a second material to form a mixture, the first material having a melting point which is lower than the second material, heating the mixture under pressure to a temperature between a melting point of the first material and a melting point of the second material, cooling the molten mixture until it hardens and removing the second material from the first material. The method may also include a subsequent annealing step. There is also described a material suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1) inch.

Abstract translation: 一种从第一材料制造多孔结构的方法。 该方法包括将第一材料与第二材料混合以形成混合物的行为，第一材料具有低于第二材料的熔点，将压力下的混合物加热到第一材料的熔点之间的温度 和所述第二材料的熔点，冷却所述熔融混合物直到其硬化并从所述第一材料除去所述第二材料。 该方法还可以包括随后的退火步骤。 还描述了适合于植入物，例如脊椎或脊髓植入物的材料，其包含刚性生物相容性聚合物，例如包含多个互连孔的PEEK。 该聚合物示例性地具有50体积％至85体积％之间的孔隙率，并且在特定实施方案中能够承受高达20MPa的压力。 多孔PEEK材料也可以具有一（1）英寸的任何尺寸的最小厚度。

公开(公告)号：US20080206186A1

公开(公告)日：2008-08-28

申请号：US11912802

申请日：2006-04-07

Applicant: Mark J. Butler ,  Michael Vivian Sefton ,  Gary Alan Skarja

Inventor： Mark J. Butler ,  Michael Vivian Sefton ,  Gary Alan Skarja

IPC: A61K31/74 ,  A61P43/00

CPC classification number: A61L27/16 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2300/10 ,  C08J2333/02 ,  C08L33/08

Abstract: A pro-angiogenic porous polymer scaffold is disclosed. The polymer has at least 20 mol-% monomeric subunits containing acidic functional groups, and has a porosity of at least 40%. The pores in the scaffold are interconnected. A method of making such a scaffold using a novel adaptation to the traditional solvent casting/particulate leaching technique is also disclosed. The scaffold may be used for tissue regeneration.

Abstract translation: 公开了一种促血管生成多孔聚合物支架。 聚合物具有至少20mol％的含有酸性官能团的单体亚基，并具有至少40％的孔隙率。 支架中的孔相互连接。 还公开了使用新型适应传统溶剂浇铸/颗粒浸出技术制造这种支架的方法。 支架可用于组织再生。

公开(公告)号：US06608117B1

公开(公告)日：2003-08-19

申请号：US09853517

申请日：2001-05-11

Applicant: Nedeljko Vladimira Gvozdic

Inventor： Nedeljko Vladimira Gvozdic

IPC: C08J926

CPC classification number: C08J9/26 ,  C08J2201/0446

Abstract: What is disclosed herein are physically cross-linked, cellular hydrogels and methods for their preparation. The cellular materials are highly resilient, hydrophilic materials having broad uses. The cellular materials are prepared by the physical crosslinking of frothed polymers and providing materials that have cellular pores provided by the use of removable materials during the formation of the cellular materials.

Abstract translation: 本文公开的是物理交联的，细胞水凝胶及其制备方法。 多孔材料是具有广泛用途的高弹性亲水材料。 多孔材料通过发泡聚合物的物理交联并通过在形成细胞材料期间使用可移除材料提供的具有细孔的材料来制备。

公开(公告)号：US06337198B1

公开(公告)日：2002-01-08

申请号：US09604945

申请日：2000-06-27

Applicant: Howard B. Levene ,  Christelle M. Lhommeau ,  Joachim B Kohn

Inventor： Howard B. Levene ,  Christelle M. Lhommeau ,  Joachim B Kohn

IPC: C21N1100

CPC classification number: A61L27/3839 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/044 ,  C08J2201/0446 ,  C08J2201/046 ,  C08J2201/048 ,  C12N5/0068 ,  C12N2533/30

Abstract: Biodegradable and biocompatible porous scaffolds characterized by a substantially continuous polymer phase, having a highly interconnected bimodal distribution of open pore sizes with rounded large pores of about 50 to about 500 microns in diameter and rounded small pores less than 20 microns in diameter, wherein the small pores are aligned in an orderly linear fashion within the walls of the large pores. Methods of preparing polymeric tissue scaffolds are also disclosed.

Abstract translation: 其特征在于具有基本上连续的聚合物相的生物可降解和生物相容的多孔支架，其具有高度相互关联的开放孔径的双峰分布，其直径为约50至约500微米的圆形大孔和直径小于20微米的圆形小孔 孔在大孔的壁内以有序的线性方式排列。 还公开了制备聚合物组织支架的方法。