-
61.发明公开公开(公告)号：US20240011019A1
公开(公告)日：2024-01-11
申请号：US18348201
申请日：2023-07-06
Inventor： Joshua LaBaer
CPC classification number: C12N15/1062 , G01N33/6845 , G01N33/6854 , G01N2458/10
Abstract: Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.
-
公开(公告)号：US20240002878A1
公开(公告)日：2024-01-04
申请号：US18327373
申请日：2023-06-01
Inventor： Samira Kiani , Mo Reza Ebrahimkhani , Jennifer Chapman
IPC: C12N15/85 , C12N9/22 , C12N15/11 , C12N15/115 , C12N15/62
CPC classification number: C12N15/85 , C12N9/22 , C12N15/11 , C12N15/115 , C12N15/62 , C12N2310/20 , C12N2800/80 , C12N15/907
Abstract: Aspects of the disclosure relate to methods and synthetic regulatory systems for more efficient nuclease-mediated homology-directed repair (HDR). In particular, provided herein are methods for more efficient in vivo and in vitro HDR-based gene editing where the methods comprise introducing into a cell a synthetic regulatory system comprising Cas nuclease, guide RNAs (gRNAs) having various lengths and configured to target distinct nucleotide sequences for simultaneous transcriptional repression (or activation) and genome editing via double stranded break and use of a donor nucleic acid molecule as a template for repair.
-
公开(公告)号：US20230408409A1
公开(公告)日：2023-12-21
申请号：US18204735
申请日：2023-06-01
Inventor： Shaopeng WANG , Pengfei ZHANG
IPC: G01N21/55 , G01N33/543 , G16B15/00
CPC classification number: G01N21/55 , G01N33/54373 , G16B15/00 , G01N2021/556
Abstract: Provided herein are methods of detecting exosomes, including unlabeled exosomes. In some embodiments, the methods include disposing a fluidic sample that comprises a plurality of exosomes in a chamber that is positioned at least partially within a fluidic device in which an inner surface of the chamber comprises a first set of exosome binding moieties that are capable of binding the exosomes. In some embodiments, the methods also include binding a portion of the plurality of exosomes to a portion of the first set of exosome binding moieties to produce surface-bound exosomes, introducing an incident light toward the inner surface of the chamber prior to, concurrent with, and/or after, producing the surface-bound exosomes, and detecting light scattered by the surface-bound exosomes to produce a set of exosome imaging data. Related fluidic devices, systems, and computer readable media are also provided.
-
公开(公告)号：US20230401452A1
公开(公告)日：2023-12-14
申请号：US18335080
申请日：2023-06-14
Inventor： Rida Bazzi , Om Thakkar
IPC: G06N3/0985 , G06N3/098
CPC classification number: G06N3/0985 , G06N3/098
Abstract: Systems and methods herein train weight-agnostic networks in a federated learning setting with orthogonal data distribution. Unlike traditional networks, weight-agnostic networks have a small size and can be trained using neural architecture search. The methods and systems described herein include sharing of a subset of networks between clients to allow federated learning for weight-agnostic networks in which clients do not have samples from all classes.
-
公开(公告)号：US20230391831A1
公开(公告)日：2023-12-07
申请号：US18032080
申请日：2021-10-13
Inventor： Alexandra Lucas , Liqiang Zhang , Jordan Yaron
IPC: C07K14/005 , A61K45/06 , A61K9/00 , A61P17/02
CPC classification number: C07K14/005 , A61K45/06 , A61K9/0014 , A61P17/02 , A61K38/00
Abstract: Wound healing is a process by which these wounds on the skin of a subject heal and eventually close. When the injured surface is large, becomes infected, or in patients with poor healing capacity such as diabetics or the elderly or bedridden patients, then wound healing can be prolonged and lead to chronic ulceration and further complications with even limb loss or increased morbidity and mortality. This invention is directed to a topical formulation for promoting wound healing, and wound dressings and bandages comprising the same.
-
Patent Agency Ranking
66.发明授权公开(公告)号：US11839144B2
公开(公告)日：2023-12-05
申请号：US17212176
申请日：2021-03-25
Inventor： Jian Li , Guijie Li , Zhi-Qiang Zhu
CPC classification number: H10K85/346 , C07F15/0086 , C09K11/06 , H05B33/14 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1029 , C09K2211/1044 , C09K2211/185 , H10K50/11 , H10K2101/10
Abstract: Platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structure:
-
67.发明公开公开(公告)号：US20230375538A1
公开(公告)日：2023-11-23
申请号：US18017563
申请日：2021-07-22
Inventor： Joshua LABAER , Jin PARK , Femina RAUF
IPC: G01N33/537 , G01N33/58
CPC classification number: G01N33/537 , G01N33/58 , G01N2458/10
Abstract: Provided herein are compositions comprising coordinated sets of unique DNA barcodes and methods for using the same for multiplex detection and measurement of multiple target molecules in multiple samples using a single next-generation sequencing reaction. In particular, methods are provided in which unique DNA barcodes linked to affinity reagents are contacted to a sample to bind antigens if present in said sample, and then a PCR-based amplification reaction adds barcoded index sequences that contain universal sequencing adaptors as well as unique barcode sequences and amplifies affinity reagent-bound targets for DNA sequencing.
-
公开(公告)号：US20230371568A1
公开(公告)日：2023-11-23
申请号：US18199277
申请日：2023-05-18
Inventor： Ivan Ermanoski , Ellen B. Stechel
IPC: A23L31/00
CPC classification number: A23L31/00
Abstract: This invention is directed to systems, compositions, and methods of producing food.
-
69.发明公开公开(公告)号：US20230366040A1
公开(公告)日：2023-11-16
申请号：US18021719
申请日：2021-08-26
Inventor： Alexander GREEN , Kaiyue WU
IPC: C12Q1/70 , C12Q1/6886 , C12Q1/6897
CPC classification number: C12Q1/701 , C12Q1/6886 , C12Q1/6897 , C12Q2600/156 , C12Q1/6804
Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of a target nucleic acid in a sample, which may be indicative of the presence of a pathogen, disease condition, or disease predisposition. In particular, provided herein is a low-cost, portable method for detecting target nucleic acid sequences that rapidly provides reliable, visible test results and does not require elaborate biosafety precautions or sophisticated laboratory equipment.
-
公开(公告)号：US11807661B2
公开(公告)日：2023-11-07
申请号：US16929001
申请日：2020-07-14
Inventor： Rachael Sirianni , Rebecca Cook , Tsafrir Mor , Joseph Blattman
IPC: A61K35/00 , C07K16/28 , A61K47/68 , C12N15/82 , A61P35/00 , A61K9/00 , C12N15/86 , C12N15/74 , A61K39/00
CPC classification number: C07K16/28 , A61K9/0019 , A61K47/6817 , A61P35/00 , C07K16/2809 , C12N15/743 , C12N15/8258 , C12N15/86 , A61K2039/505 , C07K2317/56 , C07K2317/622 , C07K2319/33 , C07K2319/55
Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
-
-
-
-
-
-
-
-
-
Search Results
1764
records
(took 0.036 seconds)
