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    STRONG BASE-INITIATED N-CARBOXYANYDRIDE RAPID RING-OPENING POLYMERISATION METHOD
    61.
    发明申请
    STRONG BASE-INITIATED N-CARBOXYANYDRIDE RAPID RING-OPENING POLYMERISATION METHOD 有权

    公开(公告)号：US20210155752A1

    公开(公告)日：2021-05-27

    申请号：US17058739

    申请日：2019-06-13

    Applicant: East China University of Science And Technology

    Inventor： Runhui Liu ,  Yueming Wu

    IPC: C08G69/10 ,  C08G69/16

    Abstract: The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.

    Electronic nose instrument for sensory quality evaluation of tobacco and tobacco product
    62.
    发明授权
    Electronic nose instrument for sensory quality evaluation of tobacco and tobacco product 有权

    公开(公告)号：US10895560B2

    公开(公告)日：2021-01-19

    申请号：US16651722

    申请日：2018-03-18

    Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： Daqi Gao ,  Zejian Wang ,  Xiaoqin Zhang ,  Jiamin Song

    IPC: G01N33/00 ,  G01N1/24 ,  G06N3/08

    Abstract: Provided is a sensory quality evaluation method for tobacco and tobacco products using an electronic nose instrument. The electronic nose instrument includes a gas sensor array module, an automatic smoke sampling system, a computer control and data analysis system, and an automatic ignition device. These components are integrated in a test box to make the instrument be structure miniaturization and work automation. The large tobacco data is established, in which the relationship between the responses of gas sensor array and the brand labels and sensory quality index scores by testing a large number of standard cigarette samples. A cascade type of modular neural networks is proposed with revised activation function and new decision-making and quantification rules to simulate the smoking and evaluating process of the professional panel. The electronic nose instrument and method realize on-site detection, discrimination and quality score estimation of a large number of tobacco and tobacco products.

    Preparation method for aerolysin nanopore and application thereof
    63.
    发明授权
    Preparation method for aerolysin nanopore and application thereof 有权

    公开(公告)号：US10788450B2

    公开(公告)日：2020-09-29

    申请号：US15546671

    申请日：2016-01-08

    Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： Yitao Long ,  Chan Cao ,  Yongxu Hu

    IPC: C12Q1/6869 ,  G01N33/487 ,  G01N27/447

    Abstract: A preparation method for an aerolysin nanopore in this disclosure comprises the following steps: (1) pretreatment of an aerolysin; (2) preparation of a lipid bilayer membrane by pulling process; (3) forming of the aerolysin nanopore: the aerolysin nanopore is obtained at a current of 50±5 pA. The aerolysin nanopore prepared in the invention is structurally stable and has a high resolution with the whole internal cavity carried with a positive charge, can be used for detection without modification and is easily operated. Further, the aerolysin nanopore can be applied in DNA sequencing, DNA damage and Micro-RNA detection.

    A Genetically-Engineered Mycobacterium Strain And A Use Thereof In The Preparation Of Steroidal Compounds
    70.
    发明申请
    A Genetically-Engineered Mycobacterium Strain And A Use Thereof In The Preparation Of Steroidal Compounds 审中-公开

    公开(公告)号：US20190264249A1

    公开(公告)日：2019-08-29

    申请号：US16310741

    申请日：2016-06-16

    Applicant: East China University Of Science And Technology

    Inventor： Fengqing Wang ,  Liqin Xu ,  Yongjun Liu ,  Haohao Liu ,  Liangbin Xiong ,  Dongzhi Wei

    IPC: C12P33/00 ,  C12R1/34 ,  C12R1/33 ,  C12R1/325 ,  C12N9/02

    Abstract: The present invention relates to a genetically-engineered Mycobacterium strain and a use thereof in the preparation of steroidal compounds. The genetically-engineered Mycobacterium strain is a Mycobacteria which lacks of acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33, wherein acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33 respectively encode proteins as follows: having amino acid sequences according to SEQ ID NOs 4, 6 and 8; derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by preceding protein and having the same function as that of the preceding protein. The present invention constructs a genetically-engineered Mycobacterium strain and applies it in preparing steroidal compounds, thereby enriching the types of valuable intermediates, improving the production efficiency and product quality of steroid drugs, reducing energy consumption in the steroid drugs production, simplifying production steps, and reducing production costs.

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