公开(公告)号：US20090118783A1

公开(公告)日：2009-05-07

申请号：US12235220

申请日：2008-09-22

Applicant: Abhilash Patangay ,  Barun Maskara ,  Jonathan Kwok ,  Jiang Ding ,  Yinghong Yu

Inventor： Abhilash Patangay ,  Barun Maskara ,  Jonathan Kwok ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/365

CPC classification number: A61N1/36592 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

Abstract: Method and systems related to monitoring right ventricular function during pacing by a cardiac rhythm management device are described. One or more pacing parameters are selected to provide cardiac resynchronization therapy. For example, the one or more pacing parameters may be selected to provide an optimal or improved therapy. The heart is paced using the selected pacing parameters. While pacing with the selected parameters, pressure is sensed via a pressure sensor disposed the pulmonary artery. The sensed pressure is analyzed to determine right ventricular function achieved during the pacing using the selected pacing parameters. A signal, such as an alert signal or control signal, is generated based on the right ventricular function achieved during the pacing.

Abstract translation: 描述了通过心律管理装置在起搏期间监测右心室功能相关的方法和系统。 选择一个或多个起搏参数以提供心脏再同步治疗。 例如，可以选择一个或多个起搏参数以提供最佳或改进的治疗。 心脏使用所选择的起搏参数进行起搏。 在使用所选参数进行起搏时，通过设置肺动脉的压力传感器检测压力。 分析检测到的压力以确定使用所选择的起搏参数在起搏期间获得的右心室功能。 基于在起搏期间实现的右心室功能，产生诸如警报信号或控制信号的信号。

公开(公告)号：US07509170B2

公开(公告)日：2009-03-24

申请号：US11124972

申请日：2005-05-09

Applicant: Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

Inventor： Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

IPC: A61N1/08 ,  A61N1/37 ,  A61B5/0452

CPC classification number: A61N1/3712 ,  A61N1/365

Abstract: Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

Abstract translation: 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。 装置和方法使用可植入电极感测复合心脏信号。 使用复合信号进行源分离。 产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。 使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。 进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。 特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

公开(公告)号：US07440803B2

公开(公告)日：2008-10-21

申请号：US11264941

申请日：2005-11-02

Applicant: Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

Inventor： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

Abstract: This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

Abstract translation: 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US20080221635A1

公开(公告)日：2008-09-11

申请号：US12048144

申请日：2008-03-13

Applicant: Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

Inventor： Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC: A61N1/365

CPC classification number: A61N1/3627

Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

Abstract translation: 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US07389141B2

公开(公告)日：2008-06-17

申请号：US10920698

申请日：2004-08-18

Applicant: Jeffrey A. Hall ,  Jiang Ding

Inventor： Jeffrey A. Hall ,  Jiang Ding

IPC: A61N1/36

CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters is presented. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval, an inter-atrial interval and a biventricular offset interval.

Abstract translation: 提出了一种用于计算和/或设置最佳心脏再同步起搏参数的方法或系统。 可以以这种方式优化的参数是心房间隔延迟间隔，心房间间隔和双心室偏移间隔。

公开(公告)号：US20080114410A1

公开(公告)日：2008-05-15

申请号：US12016830

申请日：2008-01-18

Applicant: Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

Inventor： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

Abstract: This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

Abstract translation: 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US07346393B2

公开(公告)日：2008-03-18

申请号：US10460975

申请日：2003-06-12

Applicant: Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

Inventor： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC: A61N1/36

CPC classification number: A61N1/3627

Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

Abstract translation: 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US20080021508A1

公开(公告)日：2008-01-24

申请号：US11832552

申请日：2007-08-01

Applicant: Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

Inventor： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC: A61N1/365

CPC classification number: A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

Abstract: A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

Abstract translation: 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US07310554B2

公开(公告)日：2007-12-18

申请号：US10742630

申请日：2003-12-19

Applicant: Andrew P. Kramer ,  Jiang Ding

Inventor： Andrew P. Kramer ,  Jiang Ding

IPC: A61N1/00

CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.

Abstract translation: 公开了一种用于设置由可植入心脏装置用于输送心脏再同步治疗的起搏参数的方法和系统。 在不同的实施例中，该系统可以在可植入装置和与之通信的外部编程器的编程中或在可植入装置自身的编程中实现。 起搏参数的选择至少部分地基于固有心脏传导参数的测量。 可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式和双心室偏移间隔中使用的心房延迟间隔。

公开(公告)号：US07257443B2

公开(公告)日：2007-08-14

申请号：US11184325

申请日：2005-07-19

Applicant: Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

Inventor： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC: A61N1/368

CPC classification number: A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

Abstract: A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

Abstract translation: 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。