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公开(公告)号：US20240365760A1
公开(公告)日：2024-11-07
申请号：US18650088
申请日：2024-04-30
IPC: A01K67/0276 , C12Q1/686 , C12Q1/6883
Abstract: Provided are a transgenic animal model, a method for constructing same, and use thereof. An Axin1flox/flox transgenic mouse is used to mate with an Agc1-CreER transgenic mouse to produce an Axin1+Agc1ER condition knockout mouse. Then by means of tamoxifen induction, the Axin1 expression in the Axin1+Agc1ER condition knockout mouse is down-regulated, and a disease combined model with the pathological characteristics of “growth plate chondrocyte hypertrophy, heterotopic ossification and articular cartilage degeneration of knee joints” is successfully established. The model is similar to clinically related pathological features, and can be used for systematically studying the pathogenesis of growth plate chondrocyte hypertrophy, heterotopic ossification and osteoarthritis and further screening for drugs for treating related diseases.
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公开(公告)号：US12121897B2
公开(公告)日：2024-10-22
申请号：US16769103
申请日：2018-12-21
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Hairong Zheng , Fei Li , Feiyan Cai , Long Meng , Yang Xiao , Fei Yan
CPC classification number: B01L3/502753 , B06B1/06 , B01L2400/0409 , B01L2400/0436 , B82Y35/00
Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.
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公开(公告)号：US12121229B2
公开(公告)日：2024-10-22
申请号：US17277301
申请日：2021-02-05
Inventor： Zeyang Xia , Yangzhou Gan , Hao Deng , Jing Xiong
IPC: A61B17/02 , A61B3/14 , A61B34/32 , A61B90/00 , A61F9/007 , A61G5/12 , A61B17/00 , A61B34/20 , A61F9/00
CPC classification number: A61B17/0231 , A61B3/14 , A61B34/32 , A61B90/361 , A61F9/007 , A61G5/121 , A61B2017/00057 , A61B2017/00592 , A61B2034/2065 , A61B2090/064 , A61B2090/364 , A61B2090/367 , A61F2009/0035
Abstract: A soft-bodied apparatus and a method for opening an eyelid are provided. The apparatus includes: a head support module, a real-time eyelid positioning module, a robot end-effector real-time positioning module, and an automatic eyelid opening operation module. The automatic eyelid opening operation module includes a robot body and a robot control system. The robot body is provided with a multi-axis rigid body mechanical arm and a soft-bodied end-effector. The robot control system takes the real-time poses of the upper and lower eyelids of the user as a motion target, and takes the real-time shape and the pose of the soft-bodied end-effector as feedback information to control motion of the robot body to automatically open the eyelid.
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公开(公告)号：US20240278890A1
公开(公告)日：2024-08-22
申请号：US18650549
申请日：2024-04-30
Inventor： Qi Yang ZUO , Xiao Wu HAN , Bing Bing DONG , Te LI , Chang Zhen ZHENG , Cheng Xu HAN , Kai HE
Abstract: The application relates to a swinging device, underwater bionic propeller and use thereof. The swinging device can include a swing mechanism including a swing arm. A driving end of a steering mechanism can be in transmission connection with the swing arm so as to drive the swing arm to swing in a reciprocating manner. A reciprocating mechanism can be provided which is in transmission connection with a fixed end of a steering driving component so as to drive the swing arm to rotate in a reciprocating manner by driving the steering mechanism to move. The steering mechanism drives the swing arm independently and changes the swinging area that the reciprocating mechanism drives the swing arm to swing in a reciprocating manner.
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65.发明授权公开(公告)号：US11972604B2
公开(公告)日：2024-04-30
申请号：US17283199
申请日：2020-03-11
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Shuqiang Wang , Wen Yu , Chenchen Xiao , Shengye Hu , Yanyan Shen
IPC: G06V10/82 , G06V10/774
CPC classification number: G06V10/82 , G06V10/7747
Abstract: An image feature visualization method and apparatus, and an electronic device during model training, inputs the real training data with positive samples into a mapping generator to obtain fictitious training data with negative samples. The mapping generator includes a mapping module configured to learn a key feature map that distinguishes the real training data with positive samples/negative samples, and the fictitious training data with negative samples is generated based on the real training data with positive samples and the key feature map. The training data with negative samples is input into a discriminator to obtain a discrimination result. An optimizer optimizes the mapping generator and the discriminator until training is completed. During model application, a target image that is to be processed is input into the mapping generator, and the mapper in the mapping generator extracts features of the target image.
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Patent Agency Ranking
公开(公告)号：US11937980B2
公开(公告)日：2024-03-26
申请号：US17476431
申请日：2021-09-15
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Weibao Qiu , Min Su , Zhiqiang Zhang , Hairong Zheng
IPC: A61B8/00
CPC classification number: A61B8/4461 , A61B8/4477
Abstract: A multi-row ultrasonic imaging apparatus and an ultrasonic imaging instrument are disclosed. The multi-row ultrasonic imaging apparatus includes a housing, and a first ultrasonic transducer, a second ultrasonic transducer, and an adjustment mechanism that are installed in the housing. Ultrasonic waves emitted by the first ultrasonic transducer and the second ultrasonic transducer can intersect to form a confocal point. At least one of the first ultrasonic transducer and the second ultrasonic transducer is connected to the adjustment mechanism to move relative to the housing under the action of the adjustment mechanism, so as to adjust the position of the confocal point.
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公开(公告)号：US11915003B2
公开(公告)日：2024-02-27
申请号：US18459397
申请日：2023-08-31
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Kejiang Ye , Yanying Lin , Chengzhong Xu
CPC classification number: G06F9/3806 , G06N5/046
Abstract: Disclosed are a process parasitism-based branch prediction method and device for serverless computing, an electronic device, and a readable storage medium. The method includes: receiving a calling request of a user for a target function; when capacity expansion is required, scheduling a container executing the target function to a new server that has not executed the target function in a preset period of time, wherein a parasitic process is pre-added to a base image of the container; triggering the parasitic process when the container is initialized on the new server, the parasitic process being used for initiating a system call, and triggering a system kernel to select a target template function according to the type of the target function and copying the target template function N times; using execution data of the copied N target template functions as training data to train a branch predictor on the new server.
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68.发明公开公开(公告)号：US20240046440A1
公开(公告)日：2024-02-08
申请号：US18546425
申请日：2021-04-14
Inventor： Shanshan WANG , Hairong ZHENG , Kehan QI , Chuyu RONG , Xin LIU
CPC classification number: G06T7/0002 , G06T15/00 , G06V10/44 , G06T2207/20084 , G06T2207/30168
Abstract: An image data quality evaluation method and apparatus, a terminal device, and a readable storage medium. The image data quality evaluation method includes: inputting three-dimensional image data to be evaluated into a feature extraction network model for processing to obtain a feature matrix; processing the feature matrix on the basis of a plurality, of branch network models in a hypemetwork model to obtain a plurality of parameter matrixes, and respectively adjusting, on the basis of the plurality of parameter matrixes, parameters of a plurality of fully connected layers in a corresponding regression model; and processing the feature matrix on the basis of the adjusted regression model to obtain a quality evaluation score. The dynamic adjustment of parameters of a model is implemented on the basis of content of input data, so that the processing efficiency and the quality evaluation precision for three-dimensional image data are improved.
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公开(公告)号：US11830111B2
公开(公告)日：2023-11-28
申请号：US17047062
申请日：2018-05-17
Applicant: Shenzhen Institutes of Advanced Technology
Inventor： Yanjie Zhu , Yuanyuan Liu , Dong Liang , Xin Liu , Hairong Zheng
IPC: G06T11/00 , G01R33/56 , G01R33/561 , A61B5/055
CPC classification number: G06T11/005 , G01R33/561 , G01R33/5608 , G06T11/006 , A61B5/055
Abstract: Provided are a method and device for magnetic resonance parameter imaging, medical equipment, and a storage medium. The method comprises: performing acceleration sampling with respect to an image to be reconstructed of an observation target in a preset parameter direction to acquire K-space data corresponding to the image to be reconstructed, calculating, on the basis of the K-space data and of a parameter relaxation model, a parameter value and a compensation coefficient of the image to be reconstructed, generating, on the basis of the compensation coefficient, a compensation image corresponding to the image to be reconstructed, calculating, on the basis of the compensation image, respectively a low-rank part and a sparse part of the image to be reconstructed so as to update the compensation image.
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公开(公告)号：US20230349847A1
公开(公告)日：2023-11-02
申请号：US18307936
申请日：2023-04-27
Inventor： Horst VOGEL , Zhili RAO , Xueying WANG , Xiaokang ZHANG , Shuguang YUAN , Huawei ZHANG
IPC: G01N23/2251 , G01N23/2202
CPC classification number: G01N23/2251 , G01N23/2202
Abstract: A method for determining a protein structure using cryo-electron microscopy, including: enabling a target protein to contain a tag; enabling a resulting target containing the tag to bind a scaffold protein to form a complex between the target protein and the scaffold protein; and performing single-particle imaging using the cryo-electron microscopy to determine a structure of the target protein in complex with the scaffold protein. The scaffold protein is any one of streptavidin, avidin, or derivatives thereof. The tag is configured for selectively binding to the scaffold protein. The tag is one selected from the group consisting of: a biotin tag, comprising a biotin; a biotinylated protein or polypeptide tag, comprising a protein sequence and a biotin covalently linked to the protein sequence; a Strep-tag; and a biotinylated or strep-tagged antibody, or antibody Fab fragment, or single-chain antibody.
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