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公开(公告)号：US11615559B2
公开(公告)日：2023-03-28
申请号：US17498740
申请日：2021-10-11
Inventor： Karen Panetta , Long Bao , Sos Agaian
Abstract: The present disclosure includes systems and methods for color transfer. The method includes receiving a target image, and determining dominant source colors. The method further includes transforming the target image into a color model including a target luminance component and a target color information component. Additionally, the method includes segmenting the target image into a plurality of target segments based on the target color information component or the target luminance component and extracting dominant target colors from the target image by extracting information for at least one of the dominant target colors from each target segment of the plurality of target segments. Further, the method includes generating a color mapping relationship between the dominant target colors and the dominant source colors, and creating a recolored target image using the color mapping relationship.
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公开(公告)号：US11599445B2
公开(公告)日：2023-03-07
申请号：US16442042
申请日：2019-06-14
Inventor： Tongping Liu , Hongyu Liu , Sam Albert Silvestro
Abstract: The techniques described herein may provide techniques for precise and fully-automatic on-site software failure diagnosis that overcomes issues of existing systems and general challenges of in-production software failure diagnosis. Embodiments of the present systems and methods may provide a tool capable of automatically pinpointing a fault propagation chain of program failures, with explicit symptoms. The combination of binary analysis, in-situ/identical replay, and debugging registers may be used together to simulate the debugging procedures of a programmer automatically. Overhead, privacy, transparency, convenience, and completeness challenges of in-production failure analysis are improved, making it suitable for deployment uses.
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63.发明授权公开(公告)号：US11590304B2
公开(公告)日：2023-02-28
申请号：US16325869
申请日：2017-08-15
Inventor： Craig Navarijo
Abstract: A resuscitation bag (bag valve mask resuscitator or BVM or BVMR) or other similar ventilation device (for example: anesthesia bag) includes a structure that allows a selectable, and repeatable volume be delivered to patients. The reservoir of the BVMR is formed from elastic, gastight material in the form of an elongated hollow body, with an essentially circular cross section. A range of motion control (ROMC) structure controls, or selectively limits the range of motion or collapse of the elastic bag to limit or control the volume expelled from the bag to the patient.
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公开(公告)号：US11590085B2
公开(公告)日：2023-02-28
申请号：US17572615
申请日：2022-01-10
Inventor： Qiang Cheng , Tuo Wei , Daniel J. Siegwart
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
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65.发明授权公开(公告)号：US11548894B2
公开(公告)日：2023-01-10
申请号：US16139865
申请日：2018-09-24
Inventor： Jef DeBrabander , Luis Parada
IPC: C07D487/04 , C07C205/58 , C07D207/09 , C07D209/48 , C07D211/14 , C07D213/16 , C07D213/70 , C07C205/61 , C07C235/50 , C07C255/57 , C07C271/20 , C07C323/22 , C07D401/12 , C07D307/14 , C07D295/13 , C07C323/62
Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.
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Patent Agency Ranking
66.发明授权公开(公告)号：US11531617B2
公开(公告)日：2022-12-20
申请号：US17156347
申请日：2021-01-22
Applicant: Oracle International Corporation , The Board of Regents of the University of Texas System
Inventor： Lizy John , Jee Ho Ryoo , Hung-Ming Hsu , Karthik Ganesan
IPC: G06F12/02 , G06F12/06 , G06F12/0864 , G06F12/08 , G06F3/06 , G06F12/1027
Abstract: A heterogeneous memory system is implemented using a low-latency near memory (NM) and a high-latency far memory (FM). Pages in the memory system include NM blocks stored in the NM and FM blocks stored in the FM. A page is assigned to a region in the memory system based on the proportion of NM blocks in the page. When accessing a block, the block address is used to determine a region of the memory system, and a block offset is used to determine whether the block is stored in NM or FM. The memory system may observe memory accesses to determine the access statistics of the page and the block. Based on a page's hotness and access density, the page may be migrated to a different region. Based on a block's hotness, the block may be migrated between NM and FM allocated to the page.
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公开(公告)号：US20220387520A1
公开(公告)日：2022-12-08
申请号：US17755008
申请日：2020-10-19
Applicant: Texas Biomedical Research Institute , The Board Of Regents of The University of Texas System
Inventor： Russell AULT , Niannian JI , Juan I. MOLIVA , Robert SVATEK , Jordi B. TORRELLES
Abstract: Provided are methods for treatment of bladder cancer using compositions of modified Mycobacterium bovis Bacillus Calmette et Guerin (BCG). Also, provided are methods of treatment of non-muscle invasive bladder cancer by intra-bladder injection of these modified BCG compositions. Also, provided are methods of treatment of muscle-invasive bladder cancer by intra-tumor injection of these modified BCG compositions.
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公开(公告)号：US20220370248A1
公开(公告)日：2022-11-24
申请号：US17763983
申请日：2020-09-25
Inventor： Melissa KIRKWOOD , Jeffrey GUILD , Gary ARBIQUE
IPC: A61F9/02
Abstract: The present disclosure provides a removable eyewear shielding device, an eyewear comprising a removable eyewear shielding device, and methods of uses thereof for reducing eye radiation exposure, reducing ipsilateral brain radiation exposure, reducing FGI-induced lens opacification, reducing cataract development, or protecting an eye or ipsilateral brain from radiation exposure.
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公开(公告)号：US20220347194A1
公开(公告)日：2022-11-03
申请号：US17761014
申请日：2020-09-18
Inventor： MAHMOUD SALMA AHMED , ENAS KANDIL , HESHAM SADEK , PING WANG , ROBERT BACHOO , MARK HENKEMEYER
IPC: A61K31/65 , A61K31/167 , A61K31/165 , A61K31/045 , A61K31/195 , A61P29/00 , A61P35/00 , A61K45/06
Abstract: Inhibition of EphB receptors (e.g., EphB1) can be used in therapeutic methods for treating EphB receptor-associated conditions (e.g., pain, cancer). Demeclocycline, chlortetracycline, and minocycline are identified as EphB receptor inhibitors. Accordingly, aspects of the disclosure relate to methods for treating pain comprising providing demeclocycline, chlortetracycline, minocycline, or derivatives thereof, alone or in combination, to an individual in need thereof. Further aspects relate to pharmaceutical compositions comprising two or more of minocycline, demeclocycline, chlortetracycline, and/or derivatives thereof.
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公开(公告)号：US11471449B2
公开(公告)日：2022-10-18
申请号：US16591875
申请日：2019-10-03
Inventor： Michal Geva , Ilya Bezprozvanny , Merav Bassan , Michael Hayden
IPC: A61P25/08 , A61K31/451 , A61P25/28 , A61K45/06
Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject.
The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.
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