公开(公告)号：US20220002732A1

公开(公告)日：2022-01-06

申请号：US17476803

申请日：2021-09-16

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： MYTHREYE KARTHIKEYAN ,  PRIYANKA SINGH

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P35/00

Abstract: Contact of endothelial cells with inhibitors of inhibin and/or the alpha-subunit of inhibin can be utilized to modify the activity of endothelial cell expression products including SMAD1/5. Methods can also include inhibiting ALK1 and/or endoglin as components of inhibin-activated pathway of SMAD1/5 signaling. Methods can be combined with other anti-angiogenesis therapies such as anti-VEGF therapies. Methods can be utilized in treatment of inhibin-expressing cancers (e.g., ovarian cancer, pancreatic cancer) as well as other pathologies such as pre-eclampsia and PCOS.

公开(公告)号：US20210403644A1

公开(公告)日：2021-12-30

申请号：US17242647

申请日：2021-04-28

Applicant: University of South Carolina

Inventor： Peisheng Xu

IPC: C08G69/48 ,  C08G69/26 ,  C08G69/10 ,  A61K9/51 ,  A61K47/64

Abstract: Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application.

公开(公告)号：US20210372959A1

公开(公告)日：2021-12-02

申请号：US17212021

申请日：2021-03-25

Applicant: University of South Carolina

Inventor： Chang Liu ,  Qian Wang

IPC: G01N27/12 ,  G01N33/68

Abstract: The current disclosure provides a transformative concept based on nanopore technology, Sequencing-by-Hydrolysis, to identify the N-terminal amino acid and the length of each peptide fragment in a peptide ladder to reconstitute the sequence of a protein: a protein/peptide analyte will be nonspecifically hydrolyzed to generate random fragments of the analyte that are different by one amino acid with the N-terminal amino acid of each fragment modified so it generates a distinguishable fingerprint signal when tested by nanopore. The length of the fragment can be estimated by characterizing its translocation signal to back calculate the location of the amino acid in the original analyte. This approach will significantly advance the nanopore technology with single amino acid resolution for protein/peptide sequencing.

公开(公告)号：US20210369861A1

公开(公告)日：2021-12-02

申请号：US17213750

申请日：2021-03-26

Applicant: University of South Carolina

Inventor： Peisheng Xu

IPC: A61K47/69 ,  A61K9/51 ,  A61K47/60 ,  A61K47/54

Abstract: A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.

公开(公告)号：US20210338891A1

公开(公告)日：2021-11-04

申请号：US17370101

申请日：2021-07-08

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： DOMINIC M. CASALI ,  MICHAEL A. MATTHEWS

IPC: A61L27/36

Abstract: A system and method for decellularizing tissue is provided. The system includes a pretreatment chamber including a pretreatment solution (e.g., a surfactant), a decellularization solution comprising carbon dioxide and one or more polar solvents, as well as an environmental chamber comprising a treatment chamber. The environmental chamber is maintained at a temperature greater than 31.1° C. and the carbon dioxide is maintained at a pressure greater than 7.38 megapascals to form supercritical CO2. Tissue treated with the decellularization system and method can contain less than 0.05 micrograms of DNA per milligram of dry tissue after the tissue is exposed to the decellularization solution for a time period ranging from about 1 minute to about 2 hours with minimal ECM fiber disruption. A two-part decellularization solution comprising a surfactant as well as supercritical CO2 and one or more polar solvents is also provided.

公开(公告)号：US20210304893A1

公开(公告)日：2021-09-30

申请号：US17183663

申请日：2021-02-24

Applicant: University of South Carolina

Inventor： Richard Hoppmann ,  Keith Barron, JR. ,  Robert Haddad ,  Steven Wilson ,  Floyd E. Bell, III

IPC: G16H50/20 ,  G16H50/30 ,  G16H30/40 ,  G06T7/00

Abstract: The subject matter disclosed herein is generally directed to methods and systems for generating, projecting, and displaying a patient's disease state based on the patient's medical images wherein the projected disease state can be compared to the patient's present state of health to provide data and material for patient education, healthcare provider education, clinical practice, and medical research.

公开(公告)号：US11117362B2

公开(公告)日：2021-09-14

申请号：US15936558

申请日：2018-03-27

Applicant: TIGHITCO, Inc. ,  University of South Carolina

Inventor： Michael Johannes Leonardus van Tooren ,  Ramy Harik ,  Wout De Backer ,  Arturs Peteris Bergs ,  Tawne Louis Castorina

IPC: B32B1/08 ,  B33Y80/00 ,  F24F13/02 ,  B29C64/165 ,  B33Y10/00 ,  B29L23/00 ,  B32B1/02

Abstract: A part includes a continuous fiber substantially encased in a formation material. The fiber and formation material are arranged in a plurality of alternating layers such that the formation material of a first one of the alternating layers adheres to the formation material of a second one of the alternating layers over the length of the continuous fiber. The part may include a thin-walled hollow member such as a duct. In some embodiments a part comprises a continuous fiber prepared by an additive manufacturing process comprising the steps of: depositing a composite material on a print bed using a print head, the composite material comprising a continuous fiber and a formation material in intimate contact with the continuous fiber; moving the print head and/or the print bed during the depositing of the composite material; and consolidating the composite material.

公开(公告)号：US20210276956A1

公开(公告)日：2021-09-09

申请号：US17330279

申请日：2021-05-25

Applicant: University of South Carolina ,  Senex Biotechnology, Inc.

Inventor： Igor Roninson ,  Campbell McInnes ,  Mengqian Chen ,  Li Zhang ,  Jing Li

IPC: C07D215/48 ,  C07D215/233 ,  C07D215/18 ,  C07D215/42 ,  C07D215/44 ,  A61P35/00 ,  A61P35/02

Abstract: Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.

公开(公告)号：US11065033B2

公开(公告)日：2021-07-20

申请号：US16917166

申请日：2020-06-30

Applicant: Medical University of South Carolina

Inventor： Stephen Kalhorn ,  Ryan Kellogg ,  Joe Ruscito

IPC: A61B17/34 ,  A61B17/00

Abstract: The present invention provides minimally invasive subdural evacuating systems and methods of use thereof. The subdural evacuating systems include a cutting component and a rod component, wherein the rod component provides an external physical indicator that the surface of the dura mater has been reached, permitting the cutting component to accurately pierce the dura mater with minimal to no risk of damaging any adjacent anatomy.

公开(公告)号：US11059842B2

公开(公告)日：2021-07-13

申请号：US16859007

申请日：2020-04-27

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Edward D'Antonio

IPC: A61K31/7048 ,  A61K31/7008 ,  A61K31/353 ,  A61P33/02 ,  C07H5/06

Abstract: Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.