公开(公告)号：US11751787B2

公开(公告)日：2023-09-12

申请号：US16984671

申请日：2020-08-04

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

IPC: A61M3/02 ,  A61M31/00 ,  A61B5/05 ,  A61B5/24 ,  A61B5/00 ,  A61B18/14 ,  A61B18/00 ,  A61B17/32 ,  A61B18/18 ,  A61B18/02 ,  A61B18/04 ,  A61M25/00 ,  A61B5/20 ,  A61B90/00

CPC classification number: A61B5/24 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/201 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/320069 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

公开(公告)号：US11510729B2

公开(公告)日：2022-11-29

申请号：US16717286

申请日：2019-12-17

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Steven Almany

IPC: A61B3/02 ,  A61B5/05 ,  A61M31/00 ,  A61B18/14 ,  A61B5/20 ,  A61B17/32 ,  A61B18/06 ,  A61B5/00 ,  A61B90/00 ,  A61B17/22 ,  A61B5/24 ,  A61B18/00 ,  A61B18/04 ,  A61B18/02 ,  A61B18/18 ,  A61N7/02 ,  A61M25/00 ,  A61B5/021 ,  A61B5/024

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

公开(公告)号：US20220134062A1

公开(公告)日：2022-05-05

申请号：US17524531

申请日：2021-11-11

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61M25/10 ,  A61M5/158 ,  A61M25/00 ,  A61B18/00 ,  A61B18/04 ,  A61M25/06

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

公开(公告)号：US20210220044A1

公开(公告)日：2021-07-22

申请号：US17173536

申请日：2021-02-11

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden

IPC: A61B18/14 ,  A61B17/34 ,  A61M25/00 ,  A61B90/00 ,  A61B18/04

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

公开(公告)号：US10881458B2

公开(公告)日：2021-01-05

申请号：US15947626

申请日：2018-04-06

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden

IPC: A61B18/14 ,  A61B17/34 ,  A61M25/00 ,  A61B90/00 ,  A61B18/04 ,  A61B18/00 ,  A61B5/0205 ,  A61M5/158 ,  A61M25/06 ,  A61B17/22 ,  A61B5/04 ,  A61M25/01

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

公开(公告)号：US10849685B2

公开(公告)日：2020-12-01

申请号：US16039234

申请日：2018-07-18

Applicant: Ablative Solutions, Inc.

Inventor： Andy Edward Denison ,  David R. Fischell ,  Tim A. Fischell ,  Darrin James Kent ,  Nicole Haratani

IPC: A61B18/14 ,  A61B90/00 ,  A61B18/06 ,  A61B18/00 ,  A61M25/06 ,  A61M25/00 ,  A61B18/04

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple penetrators advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, nerve sensing, nerve stimulation, or ablation by application of energy. The catheter can include a proximal handle for the advancement of guide tubes and penetrators.

公开(公告)号：US10736656B2

公开(公告)日：2020-08-11

申请号：US16296688

申请日：2019-03-08

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61B17/34 ,  A61M25/00 ,  A61B18/14 ,  A61B18/00 ,  A61B18/06 ,  A61B18/04 ,  A61B90/00 ,  A61M25/10

Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

公开(公告)号：US20200163566A1

公开(公告)日：2020-05-28

申请号：US16577327

申请日：2019-09-20

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B5/04 ,  A61B5/00 ,  A61B18/14

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US10420481B2

公开(公告)日：2019-09-24

申请号：US16034854

申请日：2018-07-13

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B3/02 ,  A61B5/04 ,  A61M31/00 ,  A61B5/00 ,  A61B18/14 ,  A61B17/32 ,  A61B5/20 ,  A61B18/18 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61M25/00 ,  A61B90/00 ,  A61B18/12 ,  A61B17/00

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US10405912B2

公开(公告)日：2019-09-10

申请号：US15154640

申请日：2016-05-13

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden

IPC: A61B18/04 ,  A61M25/01 ,  A61B18/00 ,  A61M25/00 ,  A61B18/14 ,  A61B90/00 ,  A61M25/10

Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.