公开(公告)号：US20080221635A1

公开(公告)日：2008-09-11

申请号：US12048144

申请日：2008-03-13

Applicant: Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

Inventor： Julio C. Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC: A61N1/365

CPC classification number: A61N1/3627

Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

Abstract translation: 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US07389141B2

公开(公告)日：2008-06-17

申请号：US10920698

申请日：2004-08-18

Applicant: Jeffrey A. Hall ,  Jiang Ding

Inventor： Jeffrey A. Hall ,  Jiang Ding

IPC: A61N1/36

CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters is presented. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval, an inter-atrial interval and a biventricular offset interval.

Abstract translation: 提出了一种用于计算和/或设置最佳心脏再同步起搏参数的方法或系统。 可以以这种方式优化的参数是心房间隔延迟间隔，心房间间隔和双心室偏移间隔。

公开(公告)号：US20080114410A1

公开(公告)日：2008-05-15

申请号：US12016830

申请日：2008-01-18

Applicant: Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

Inventor： Jiang Ding ,  Julio Spinelli ,  Yinghong Yu ,  Jeffrey Stahmann

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

Abstract: This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

Abstract translation: 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US07346393B2

公开(公告)日：2008-03-18

申请号：US10460975

申请日：2003-06-12

Applicant: Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

Inventor： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

IPC: A61N1/36

CPC classification number: A61N1/3627

Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

Abstract translation: 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

公开(公告)号：US20080021508A1

公开(公告)日：2008-01-24

申请号：US11832552

申请日：2007-08-01

Applicant: Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

Inventor： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC: A61N1/365

CPC classification number: A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

Abstract: A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

Abstract translation: 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US07310554B2

公开(公告)日：2007-12-18

申请号：US10742630

申请日：2003-12-19

Applicant: Andrew P. Kramer ,  Jiang Ding

Inventor： Andrew P. Kramer ,  Jiang Ding

IPC: A61N1/00

CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.

Abstract translation: 公开了一种用于设置由可植入心脏装置用于输送心脏再同步治疗的起搏参数的方法和系统。 在不同的实施例中，该系统可以在可植入装置和与之通信的外部编程器的编程中或在可植入装置自身的编程中实现。 起搏参数的选择至少部分地基于固有心脏传导参数的测量。 可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式和双心室偏移间隔中使用的心房延迟间隔。

公开(公告)号：US07257443B2

公开(公告)日：2007-08-14

申请号：US11184325

申请日：2005-07-19

Applicant: Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

Inventor： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC: A61N1/368

CPC classification number: A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

Abstract: A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

Abstract translation: 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US20070162081A1

公开(公告)日：2007-07-12

申请号：US11689646

申请日：2007-03-22

Applicant: Yinghong Yu ,  Jiang Ding ,  Joseph Pastore

Inventor： Yinghong Yu ,  Jiang Ding ,  Joseph Pastore

IPC: A61N1/365

CPC classification number: A61N1/365

Abstract: A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.

Abstract translation: 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行MI重建控制。

公开(公告)号：US20070125703A1

公开(公告)日：2007-06-07

申请号：US11400428

申请日：2006-04-06

Applicant: John Chapman ,  Jiang Ding ,  Yu-Ling Hsiao ,  Christian Lenges ,  Yanhui Niu ,  Stefan Reinartz ,  Cheryl Stancik ,  Judith Van Gorp

Inventor： John Chapman ,  Jiang Ding ,  Yu-Ling Hsiao ,  Christian Lenges ,  Yanhui Niu ,  Stefan Reinartz ,  Cheryl Stancik ,  Judith Van Gorp

IPC: B01D29/00

CPC classification number: B01D39/1607 ,  B01D39/083 ,  B01D39/086 ,  B01D39/2017 ,  B01D39/2041 ,  B01D39/2082 ,  B01D46/546 ,  B01D2239/0225 ,  B01D2239/0233 ,  B01D2239/025 ,  B01D2239/0478 ,  B01D2239/0492 ,  B01D2239/0622 ,  B01D2239/0627 ,  B01D2239/0631 ,  B01D2239/065 ,  B01D2239/0654 ,  B01D2239/10 ,  B01D2239/1216 ,  B01D2239/1233 ,  Y10T428/249921

Abstract: The invention is a process useful for providing a treated support comprising a porous nanoweb coating wherein the treated support is characterized by a biofilm cell count of less than 50% that of an untreated porous support control. The process is useful for modifying porous materials, such as filter media and barrier fabrics to provide resistance to biofouling. The porous nanoweb coating is comprised of fibrous structures derived from gelation and drying of supramolecular assemblies of non-covalently bonded organogelators. Typical organogelators useful in the invention include those that assemble via hydrogen bonding and π-stacking.

Abstract translation: 本发明是一种可用于提供包含多孔纳米网涂层的经处理的载体的方法，其中经处理的载体的特征在于生物膜细胞计数小于未处理的多孔支持物对照的50％。 该方法可用于改性多孔材料，例如过滤介质和阻隔织物以提供抵抗生物污垢。 多孔纳米网涂层由衍生自非共价键合的有机凝胶的超分子组装的凝胶化和干燥的纤维结构组成。 用于本发明的典型有机凝胶包括通过氢键和π-叠层组装的有机凝胶。

公开(公告)号：US20060259086A1

公开(公告)日：2006-11-16

申请号：US11126490

申请日：2005-05-11

Applicant: Yinghong Yu ,  Jiang Ding ,  Jeffrey Stahmann

Inventor： Yinghong Yu ,  Jiang Ding ,  Jeffrey Stahmann

IPC: A61N1/362

CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/3706

Abstract: Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.

Abstract translation: 在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。 在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。 在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。 在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。 各种系统和方法的组合也是可能的。