公开(公告)号：US20070197918A1

公开(公告)日：2007-08-23

申请号：US11736109

申请日：2007-04-17

Applicant: Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

Inventor： Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

IPC: A61B8/14

CPC classification number: A61B17/2202 ,  A61B17/2251 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/22028 ,  A61B2017/2253 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0078

Abstract: An apparatus for delivering acoustic energy to a target site adjacent a body passage includes first and second elongate members, each carrying one or more transducer elements on their distal ends. The first and/or second elongate members include connectors for securing the first and second elongate members together such that the transducer elements together define a transducer array. The first and second elongate members are introduced sequentially into a body passage until the transducer elements are disposed adjacent a target site. Acoustic energy is delivered from the transducer elements to the target site to treat tissue therein. In another embodiment, the apparatus includes a tubular member and an expandable structure carrying a plurality of transducer elements. The structure is expanded between a contracted configuration during delivery and an enlarged configuration when deployed for delivering acoustic energy to a target site adjacent the body passage.

Abstract translation: 用于将声能递送到身体通道附近的目标部位的装置包括第一和第二细长构件，每个细长构件在其远端上承载一个或多个换能器元件。 第一和/或第二细长构件包括用于将第一和第二细长构件固定在一起的连接器，使得换能器元件一起限定换能器阵列。 将第一和第二细长构件顺序地引入体通道中，直到换能器元件邻近目标位置设置。 声能从传感器元件输送到目标部位以在其中处理组织。 在另一个实施例中，该装置包括管状构件和承载多个换能器元件的可膨胀结构。 该结构在递送期间的收缩构造和在被部署以用于将声能递送到邻近身体通道的目标部位时的放大配置之间扩展。

公开(公告)号：US07175596B2

公开(公告)日：2007-02-13

申请号：US10020737

申请日：2001-10-29

Applicant: Shuki Vitek ,  Avner Ezion

Inventor： Shuki Vitek ,  Avner Ezion

IPC: A61B8/00

CPC classification number: G01S15/8909 ,  A61B2018/00642 ,  A61B2090/374 ,  A61N7/02 ,  G01S7/52025 ,  G01S7/52058

Abstract: A method for sensing a disturbance in a transmission path of a converging ultrasound energy beam transmitted by a transducer in a focussed ultrasound system comprises transmitting a burst of ultrasound energy from the transducer, detecting whether a reflected portion of the ultrasound energy burst is received at the transducer within a certain time period following transmission of the burst, and, if so, analyzing the received reflected portion to determine a characteristic of the disturbance.

Abstract translation: 用于感测在聚焦超声系统中由换能器发射的会聚超声能量束的传播路径中的干扰的方法包括从所述换能器传输超声能量脉冲串，检测所述超声波能量突发的反射部分是否在 在传输脉冲串之后的特定时间段内的传感器，如果是，则分析所接收的反射部分以确定干扰的特性。

公开(公告)号：US06735461B2

公开(公告)日：2004-05-11

申请号：US09884206

申请日：2001-06-19

Applicant: Shuki Vitek ,  Avner Ezion ,  David Freundlich

Inventor： Shuki Vitek ,  Avner Ezion ,  David Freundlich

IPC: A61B5055

CPC classification number: G01R33/28 ,  G01R33/4804

Abstract: Systems and methods for performing a focused ultrasound procedure monitored using magnetic resonance imaging (MRI) is provided. An MRI system uses a timing sequence for transmitting radio frequency (RF) signals and detecting magnetic resonance (MR) response signals from a patient's body in response to the RF pulse sequences. A piezoelectric transducer is driven with drive signals such that the transducer emits acoustic energy towards a target tissue region within the patient's body. Parameters of the drive signals are changed at times during the timing sequence that minimize interference with the MRI system detecting MR response signals, e.g., during transmission of RF signals by the MRI system.

Abstract translation: 提供了使用磁共振成像（MRI）监测的用于执行聚焦超声程序的系统和方法。 MRI系统使用用于响应于RF脉冲序列从患者身体发射射频（RF）信号和检测磁共振（MR）响应信号的定时序列。 用驱动信号驱动压电换能器，使得换能器向患者体内的目标组织区域发射声能。 驱动信号的参数在定时序列期间的时间被改变，以使MRI检测MR响应信号的干扰最小化，例如在MRI系统的RF信号传输期间。

公开(公告)号：US06618620B1

公开(公告)日：2003-09-09

申请号：US09724670

申请日：2000-11-28

Applicant: David Freundlich ,  Jacob Vortman ,  Roni Yagel ,  Shuki Vitek ,  Naama Brenner

Inventor： David Freundlich ,  Jacob Vortman ,  Roni Yagel ,  Shuki Vitek ,  Naama Brenner

IPC: A61N1368

CPC classification number: A61N7/02 ,  A61B34/10 ,  A61B2017/00084 ,  A61B2090/374

Abstract: A thermal treatment system including a heat applying element for generating thermal doses for ablating a target mass in a patient, a controller for controlling thermal dose properties of the heat applying element, an imager for providing preliminary images of the target mass and thermal images during the treatment, and a planner for automatically constructing a treatment plan, comprising a series of treatment sites that are each represented by a set of thermal dose properties. The planner automatically constructs the treatment plan based on input information including one or more of a volume of the target mass, a distance from a skin surface of the patient to the target mass, a set of default thermal dose prediction properties, a set of user specified thermal dose prediction properties, physical properties of the heat applying elements, and images provided by the imager. The default thermal dose prediction properties are preferably based on a type of clinical application and include at least one of thermal dose threshold, thermal dose prediction algorithm, maximum allowed energy for each thermal dose, thermal dose duration for each treatment site, cooling time between thermal doses, and electrical properties for the heat applying element. The user specified thermal dose prediction properties preferably include at least one or more of overrides for any default thermal dose prediction properties, treatment site grid density; and thermal dose prediction properties not specified as default thermal dose prediction properties from the group comprised of thermal dose threshold, thermal dose prediction algorithm, maximum allowed energy for each thermal dose, thermal dose duration for each treatment site cooling time between thermal doses, and electrical properties for the heat applying element.

Abstract translation: 一种热处理系统，包括用于产生热剂量以消除患者中的目标物质的热施加元件，用于控制加热元件的热​​剂量特性的控制器，用于在所述加热元件期间提供目标​​物质的预备图像和热图像的成像器 治疗和用于自动构建治疗计划的计划者，其包括由一组热剂量特性表示的一系列治疗部位。 计划者根据输入信息自动构建治疗计划，该输入信息包括一个或多个目标质量体积，从患者皮肤表面到目标质量的距离，一组默认热剂量预测属性，一组用户 指定的热剂量预测性质，热施加元件的物理特性和由成像器提供的图像。 默认的热剂量预测性质优选地基于一种临床应用，并且包括热剂量阈值，热剂量预测算法，每个热剂量的最大允许能量，每个治疗部位的热剂量持续时间，热量之间的冷却时间 剂量和电气性能。 用户指定的热剂量预测性质优选包括用于任何默认热剂量预测性质，治疗部位网格密度的至少一个或多个覆盖; 和热剂量预测性质未被指定为由热剂量阈值，热剂量预测算法，每个热剂量的最大允许能量，热剂量之间的每个处理部位冷却时间的热剂量持续时间和电热量的预定热剂量预测性质 热施加元件的特性。

公开(公告)号：US06506154B1

公开(公告)日：2003-01-14

申请号：US09724611

申请日：2000-11-28

Applicant: Avner Ezion ,  Kolisher Izzydor ,  Shuki Vitek

Inventor： Avner Ezion ,  Kolisher Izzydor ,  Shuki Vitek

IPC: A61B800

CPC classification number: G10K11/341

Abstract: Systems and methods for controlling the phase and amplitude of individual drive sinus waves of a phased-array focused ultrasound transducer employ digitally controlled components to scale the amplitude of three or more bases sinuses into component sinus vectors. The component sinus vectors are linearly combined to generate the respective sinus of a selected phase and amplitude. The use of digitally controlled controlled components allows for digitally controlled switching between various distances, shapes and orientations (“characteristics”) of the focal zone of the transducer. The respective input parameters for any number of possible focal zone characteristics may be stored in a comprehensive table or memory for readily switching between focal zone characteristics in &mgr; seconds. Changes in the output frequency are accomplished without impacting on the specific focal zone characteristics of the transducer output. Sequential changes in the transducer focal zone characteristics are implemented in the form of sequential sets of digital control signals transmitted from the central controller to respective control channels for generating the individual sinus waves. The digital control signals may be changed in accordance with a time-domain function as part of a single thermal dose.

Abstract translation: 用于控制相控阵聚焦超声换能器的单个驱动窦波的相位和振幅的系统和方法使用数字控制的分量来将三个或更多个基极窦的幅度缩放成分量窦性矢量。 组分窦性矢量被线性组合以产生所选相位和幅度的相应窦。 使用数字控制的受控组件允许在换能器的焦点区域的各种距离，形状和取向（“特性”）之间进行数字控制的切换。 任何数量的可能焦点区域特征的各个输入参数可以存储在综合表或存储器中，以便在mu秒内容易地切换焦点区域特性。 在不影响传感器输出的特定焦点区域特性的情况下实现输出频率的变化。 换能器焦区特性的顺序变化以从中央控制器发送到用于产生单个窦波的相应控制通道的顺序数字控制信号集的形式实现。 可以根据作为单一热剂量的一部分的时域功能来改变数字控制信号。

公开(公告)号：US06419648B1

公开(公告)日：2002-07-16

申请号：US09556095

申请日：2000-04-21

Applicant: Shuki Vitek ,  Naama Brenner

Inventor： Shuki Vitek ,  Naama Brenner

IPC: A61N702

CPC classification number: A61N7/02 ,  A61B8/4494 ,  A61N2007/0065 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0095 ,  B06B1/0284 ,  G10K11/346

Abstract: System and methods for performing a therapeutic procedure using focused ultrasound include providing a piezoelectric transducer including a plurality of transducer elements, such as a concave concentric ring array or a liner array of transducer elements. Drive circuitry is coupled to the transducer for providing drive signals to the transducer elements at one of a plurality of discrete RF frequencies. A controller is coupled to the drive circuitry for periodically changing a frequency of the drive signals to one of the plurality of discrete frequencies, while controlling a phase component of the drive signals to maintain the focus of the transducer at a primary focal zone during a single sonication.

Abstract translation: 使用聚焦超声波进行治疗过程的系统和方法包括提供包括多个换能器元件的压电换能器，例如凹形同心环阵列或换能器元件的衬垫阵列。 驱动电路耦合到换能器，以在多个离散RF频率中的一个处向换能器元件提供驱动信号。 控制器耦合到驱动电路，用于周期性地将驱动信号的频率改变为多个离散频率之一，同时控制驱动信号的相位分量，以在单个时间段期间将换能器的焦点保持在主要焦点区域 超声处理